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Background. The procedure of human islet isolation needs further optimization and standardization. Here, we describe techniques to enhance enzymatic digestion and minimize mechanical forces during the digestion process. The isolation protocol has also been modified to meet current GMP (cGMP) standards. Moreover, the impact of donor- and process-related factors was correlated to the use of islets f

Popular Abstract in Swedish Ultraljud brukar oftast förknippas med diagnostiska metoder såsom fosterdiagnostik men kan även användas för terapeutisk behandling. Terapeutiskt ultraljud bygger på att ljudet absorberas i vävnaden och därigenom ger upphov till en ökad temperatur. Temperaturökningen är beroende av ultraljudets intensitet samt ultraljudsabsorptionen i den aktuella vävnaden. Genom att foThe purpose of this study was to study and try to optimise high intensity focused ultrasound treatment of the intervertebral disc. We demonstrated that it was possible to heat intervertebral discs with HIFU delivered by 50 or 5 mm diameter ultrasound transducers. Finite element studies indicated that it would be possible to heat the disc to a temperature of 65ºC or above through an extradiscal m

We study the large-time dynamics of a Markov process whose states are finite but unbounded graphs. The number of vertices is described by a supercritical branching process, and the edges follow a certain mean-field dynamics determined by the rates of appending and deleting: the older an edge is, the lesser is the probability that it is still in the graph. The lifetime of any edge is distributed ex

Reaction of [Os3(CO)11(NCMe)] with R2S (R = Et, nPr) and MeSBut results in the formation of [Os3(CO)11(L)] (L = thioether) clusters in which the thioethers are coordinated in an equatorial site of the triosmium framework. Such monosubstituted clusters are also formed when [Os3(CO)10(NCMe)2] is reacted with R2S (R = Et, nPr) while reaction of the same cluster with Ph2S or MeSPh results in the forma

n this study, we show that costimulation required for mucosal IgA responses is strikingly different from that needed for systemic responses, including serum IgA. Following oral immunization with cholera toxin (CT) adjuvant we found that whereas CTLA4-H{gamma}1 transgenic mice largely failed to respond, CD28-/- mice developed near normal gut mucosal IgA responses but poor serum Ab responses. The lo

Wind speed and direction have a significant effect on a flying bird's ground speed. Migrants are therefore expected to be sensitive to wind conditions and this should have consequences for optimal strategies of stopover and refuelling. Based on an earlier model of time-minimizing migration which includes wind condition, we investigate the consequences of the temporal correlation of wind conditions

The autumn migration of raptors at Falsterbo, Sweden has been studied since the early 1940s, and from 1973 standardized counts were made. Here we present data for 15 species over a 39-year period from 1942-97. These are discussed in the context of available information on population trends in Sweden and neighbouring countries. Although annual numbers and concentration rate vary considerably betwee

The effect of adding a Thermomyces (formerly Humicola) lanuginosa lipase (TLL) to a cubic dispersion of the binary monoolein (MO)-(H2O)-H-2 system and to vesicles formed by the ternary MO-sodium oleate (NaO)(H2O)-H-2 system at high water content has been studied. The change in lipid aggregate structure during the lipolytic process was observed by light microscopy, cryo-TEM, and dynamic light scatt

Allochthonous organic carbon in aquatic systems is metabolized by heterotrophic bacteria, with significant consequences for the biostructure and energy pathways of freshwater ecosystems. The degree to which allochthonous substrates support growth of bacteria is largely dependent on bacterial growth efficiency (BGE), i.e., bacterial production ( BP) per unit of assimilated carbon. Here we show how

Co(II) adsorption at ZnO- and ZnS-aqueous interfaces was studied with the XAFS technique. The results show the presence of both 4- and 6-coordinated oxygen-ligated Co(II) on ZnO, corresponding to Co-O distances of 1.95 and 2.1 Angstrom, respectively. At ZnS two Co-O distances are also indicated and a Co-S correlation at 2.36 Angstrom is revealed. Higher shell analysis indicates a fraction of biden

Several bacterial species express surface proteins with affinity for the constant region (Fc) of immunoglobulin (Ig) G. The biological consequences of the interaction with IgG are poorly understood but it has been demonstrated that genes encoding different IgG Fc-binding proteins have undergone convergent evolution, suggesting that these surface molecules are connected with essential microbial fun

Popular Abstract in Swedish De personer som ingår i undersökningen har gemensamt att de har erfarenheter av flera års avancerat narkotikamissbruk, varit drogfria i minst två år samt att de idag är socialt integrerade. Det faktum att de lyckats sluta missbruka narkotika och idag lever "vanliga liv" innebär att de tillhör en grupp som hitintills fått mycket liten uppmärksamhet av missbruksforskningeAim of the study, background, theory and method The two aims of this study are to describe and analyse: i) how drug abusers have transformed their lives from the time when they did not use drugs, to becoming drug abusers, and finally leaving drugs behind them; and ii) what it means to be socially integrated with one's experience of having been a drug abuser. The women and men who participated in

A reinvestigation of the phase diagrams relative to some conjugated and non-conjugated bile salts in water has demonstrated the formation of lyotropic liquid crystalline phases, in contradiction with generally accepted statements. The phase behaviour is complex and the phase diagrams are unusual, compared to most surfactants and lipids. In particular, coexistence of liquid crystalline phases with

The NW-SE oriented Sorgenfrei–Tornquist Zone (STZ) has been thoroughly studied during the last 25 years, especially by means of well data and seismic profiles. We present the results of a first brittle tectonic analysis based on about 850 dykes, veins and minor fault-slip data measured in the field in Scania, including paleostress reconstruction. We discuss the relationships between normal and str

Popular Abstract in Swedish Syftet har varit att studera tillämpningen av ventilation i skolbyggnader. Huvuddelen av avhandlingen behandlar vädring av klassrum. Analytiska modeller med vilka luftutbytet orsakat av vädring kan beräknas föreslås. Ett mål är att modellerna skall utgöra ett verktyg för projektörer och brukare. Modellerna skall kunna användas när man vill bestämma tidslängden för vädriThe objective of this thesis is to study the application of ventilation in schools buildings. A number of studies of the application of different forms of ventilation are presented. The main part of the thesis focuses on window opening in a classroom. Analytical models for calculation of the air change caused by window airing are proposed. The models are intended to be a tool for designers and occ

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Recension av Jonny Ambrius; Att dömas till döden. Tortyr, kroppsstraff och avrättningar genom historien

ECGs were recorded from three electrodes attached at the corners of an equilateral triangle positioned around the location of electrode V1. The atrial signal between QRST complexes was subjected to correlation function analysis to reveal differences in activation times between the electrode sites. The time differences found were used to calculate the direction of activation across the body surface

A generic, fast, sensitive and new type of flow immunosensor has been developed. The basis is a monolithic porous poly(glycidyl methacrylate-co-trimethylolpropane trimethacrylate) polymer disc modified with protein G, placed in a fountain type flow cell compartment, in close proximity to a photomultiplier tube (PMT). Analyte and HRP labelled analyte derivative (tracer) compete for anti-analyte ant