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In most patients, Parkinson's disease is thought to emerge after a lifetime of exposure to, and interaction between, various genetic and environmental risk factors. One of the key genetic factors linked to this condition is α-synuclein, and the α-synuclein protein is pathologically associated with idiopathic cases. However, α-synuclein pathology is also present in presymptomatic, clinically “norma
There was a substantial trade in furs throughout the medieval period, as indicated by a number of written sources. The archaeological evidence for this trade is, however, scant. The discovery of furriers’ workshops depends to a significant extent on the large-scale sieving of soil samples, since most bones from fur-bearing species are small. As large-scale sieving for small bones is not often unde
The European Spallation Source (ESS), planned to be operational in 2019, is anticipated to be the worlds most intense neutron source. The total beam power will be 5 MW. We focus on the impact of manufacturing errors on the beam quality. In particular we assess the emittance dilution which occurs due to Higher Order Modes (HOMs) excited at a harmonic of the bunch frequency. We also discuss some ali
This paper is focused on implementation challenges related to the integration of sustainable mobility in strategic local/regional land use and transport planning. The work was based on a case study of Stockholm, Sweden, focusing on four current plans and strategies of key importance for sustainable mobility. We identify and discuss implementation challenges related to sustainable mobility using a
In this paper we analyse the interplay between services and manufacturing. This is done through identifying and quantifying a direct link between manufacturing exports and the sales by service providers. For identification of this transmittance mechanism, with the help of highly detailed geographic data, we create a Localised Export Exposure (LEE) variable that captures the variation in demand for
Digitalization is considered key to meeting the challenges that face the healthcare sector. However, the results of digitalization initiatives have often been disappointing and the literature has provided a fragmented understanding of the mixed results. While previous studies have generally focused on the advantages and the barriers of adopting healthcare IS, little attention has been paid to unea
OBJECTIVES: Increased vulnerability to stress has been suggested as a possible mechanism behind medically unexplained conditions such as sensitivity to electricity and common smells. This study examined whether subjective environmental annoyance among the general population is associated with increased physiological reactivity or subjective stress scores.METHODS: Four groups were studied (N=141):
This paper reviews the peer-reviewed scientific literature on interventions aimed to reduce human fear of large carnivores in human-large carnivore conflicts. Based on psychological theories, a wide definition of fear was adopted, including fear as an emotion, as a perception and as an attitude. Four major categories of interventions were identified: information and education, exposure to animal a
This article demonstrates how Swedish support organisations approach and target immigrant entrepreneurs in terms of categorisation and labelling. In their strategic positioning, and as a result of framing and communicating specific target groups for their activities, organisations simultaneously produce and reproduce categories of clients. We argue that despite its emancipatory intent, the process
In a global competitive economic environment, resources that are scarce or irreplicable are a source of sustained competitive advantage for companies and organizations. Knowledge-based resources are a major and increasing driver of long term competitive advantage. Most accounting standards however do not allow for knowledge-based resource calculations, including the most important of these, intell
The is a review of Jonna Bornemark's book "Kroppslighetens mystik: en filosofisk läsning av Mechthild von Magdeburg", a book where she carries out a conversation with the 15th century beguin Mechthild via her texts; about central existential themes in connection with the bodily mystical experiences of Mechthild. Bornemark manages to do this with respect for Mechthild's own religious interpretation
Of all the huge natural disasters that claimed the lives of thousands in Asia, the Indian Ocean tsunami in 2004 was the largest, estimated to have killed more than 230,000 people. The scope of damage brought about by this natural disaster urges focus on recovery and post-disaster reconstruction from several perspectives. Here we find an in-depth ethnography of Thailand and the role of culture and
This paper suggests an infrastructure perspective, as suggested by Star and Bowker (2006), as an analytical framework for studying the research evaluation landscape. An infrastructure is suggested to be understood, not as a concrete technology, but as a system of contextual factors including ‘Actors/Stakeholders’, ‘Technical systems’, and ‘Evaluation practices’. How the framework can be operationaThis paper suggests an infrastructure perspective, as suggested by Star and Bowker (2006), as an analytical framework for studying the research evaluation landscape. An infrastructure is suggested to be understood, not as a concrete technology, but as a system of contextual factors including ‘Actors/Stakeholders’, ‘Technical systems’, and ‘Evaluation practices’. How the framework can be operationa
Purpose – This chapter presents a framework for an action research based intervention to develop and transform sustainable healthcare in a regional context. The framework is illustrated by the case of the Regional Cancer Centre (RCC) West in western Sweden. Design/methodology/approach – The framework draws upon and develops Pettigrew’s context-content-process model of strategic change and applies
Myocardial infarction and stroke are two of the most common causes of death in the world, mainly caused by a rupture of an atherosclerotic plaque. A vulnerable atherosclerotic plaque is a high-risk plaque that can form a thrombus by rupture. The phenotype of a plaque prone to rupture includes a thin fibrous cap, a large lipid core, accumulation of macrophages, a fissured fibrous cap and high-grade
Modeling is of key importance in fuel cell development beyond the current-state-of-the-art because it is beneficial to understand the mechanisms of various interacting phenomena and effects on the cell performance. It is also hard to measure the local parameters inside fuel cells, particularly inside the small scale functional materials. Modeling and simulation of charge transfer and electrochemic
