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Background: European treatment guidelines recommend prasugrel over ticagrelor for treating patients with non–ST-elevation acute coronary syndrome (ACS), prompting several Swedish administrative regions to transition from ticagrelor to prasugrel as the preferred treatment for patients with ACS. We aim to systematically evaluate this transition to determine the relative efficacy of prasugrel versus

We developed models for individualized risk prediction of cognitive decline in mild cognitive impairment (MCI) using plasma biomarkers of β-amyloid (Aβ), tau and neurodegeneration. A total of 573 patients with MCI from the Swedish BioFINDER study and the Alzheimer’s Disease Neuroimaging Initiative (ADNI) were included in the study. The primary outcomes were longitudinal cognition and conversion to

Context: Growth hormone (GH) is used to treat short children born small for gestational age (SGA); however, the effects of treatment on pubertal timing and adult height are rarely studied. Objective: To evaluate adult height and peak height velocity in short GH-treated SGA children. Methods: Prospective longitudinal multicenter study. Participants were short children born SGA treated with GH thera

Self-assembly and fibril formation play important roles in protein behaviour. Amyloid fibril formation is well-studied due to its role in neurodegenerative diseases and characterized by refolding of the protein into predominantly β-sheet form. However, much less is known about the assembly of proteins into other types of supramolecular structures. Using cryo-electron microscopy at a resolution of

Phytochemicals have been used as one of the sources for the development of anti-obesity drugs. Plants are rich in a variety of bioactive compounds including polyphenols, saponins and terpenes. Phytochemicals inhibit adipocyte differentiation by inhibiting the transcription and translation of adipogenesis transcription factors such as C/EBPα and PPARγ. It has been proved that phytochemicals inhibit

Complete 4F2 vertical nanowire (VNW) 1T1R cells with 106 cycles switching endurance and with a demonstrated capability of performing Boolean logic are fabricated and characterized in cross-point arrays. The performance of the vertical 1T1R cell is benefited from using the same III-V/high- k interface both for the vertical GAA MOSFET selector as well as the ReRAM. In this paper, we also compare the

In the last decade a number of women-led mosques have emerged in Europe and North America. In The Making of a Mosque with Female Imams Jesper Petersen documents the serendipitous, yet predictable, emergence of the Mariam Mosque in Copenhagen. The study first demonstrates that individuals’ facing the unpredictable plays a decisive role in social processes. This leads to an investigation of how sere

We propose a consensus definition of "an exaggerated orthostatic pressor response" in subjects in whom systolic blood pressure increases ≥ 20 mmHg when going from supine to standing posture. This definition can be extended for seated to standing measurements. We reserve the term "orthostatic hypertension" for when this pressor response leads to an upright systolic blood pressure ≥ 140 mmHg. We bel

AIMS: This study aims to determine the familial incidence of dilated (DCM) and hypertrophic cardiomyopathy (HCM) in first-degree, second-degree, and third-degree relatives of affected individuals.METHODS AND RESULTS: In this population-based multigenerational cohort study, full-siblings, half-siblings, and cousin pairs born to Swedish parents between 1932 and 2015 were included, and register-based

The city of Copenhagen, often celebrated as one of the world’s greenest for its cycling culture and other initiatives, recently defaulted on its pledge to become carbon-neutral by 2025. This early failure in the global race to net zero emissions (a balance between CO₂ emitted and absorbed) may foreshadow backtracking by other target-setters, indicating that pledges to cease contributing to climate

This study provides a cross-platform, longitudinal investigation of pictures depicting political candidates posted to Facebook and Instagram over a 15-month period during the 2020 US election(n = 4,977). After motivating an exploratory research design, we set out to expound: the extent of cross-platform image posting across Facebook and Instagram; the emotion expression of politicians across the t

Recreational hunting in Sweden can be depicted as being embedded in two different but overlapping cultural and socio-economic contexts. One is the traditional stewardship-oriented form of hunting, in Swedish called ‘allmoge’ hunting. Another form is the commercial form of hunting, where hunting is packaged and offered to visitors, quite often with different types of services included. These two fo

Spectra emitted from laser-produced plasmas of scandium, titanium, vanadium and chromium have been recorded in the region 270-600 Å, and lines belonging to the 3s-3p and 3p-3d transition arrays in neonlike ions have been identified. The 2p53s, 3p and 3d energy levels have been derived from the observations for Ti XIII and from solar flare lines for Fe XVII. Hartree-Fock calculations and parametric

The gallium spectrum emitted from a hollow cathode has been recorded in the region 500-9800 A. 142 lines have been classified as transitions in Ga II. Energy levels have been derived from the observations, and perturbations within the n = 4 configuration complex are discussed. Besides the previously known mixing between 4s4d and 4p2, it has been found that the structure of 4s4/is strongly affected

Average energies for the configurations 2p5 3s, 3p and 3d in a number of neon-like ions from Al IV to Xe XLV have been calculated by means of the MCDF computer code of Grant et al. The results have been compared with observations and previous non-relativistic calculations. Fine- structure levels and 3s-3p and ip-3d transition wavelengths have also been calculated with the MCDF code for Ti XIII and

Results from the radiological environmental monitoring of the European Spallation Source (ESS) are presented for 2021. Previous zero-point assessments (2017-2020) have mainly focussed on terrestrial samples. New sample types for 2021 include a sediment sample from a pond at the ESS and brown seaweed (Fucus) from Lomma bay and from the east coast of Scania (Skillinge). For gamma-emitting radionucli

Objective: To determine whether a tight control (TC) regime with monthly consultations to the physician for the first 6 months, could increase remission rate and improve reported pain of patients with early rheumatoid arthritis (RA). Methods: In this single-centre, TC study, with monthly visits to the physician, a cohort of 100 patients with early RA was consecutively included. They were compared

Abnormal metabolism of β-amyloid (Aβ) and soluble phosphorylated tau (P-tau), as well as neurodegeneration, are key components of Alzheimer disease (AD), but it is unclear how these different processes are related to genetic risk factors for AD.MethodsIn the Swedish BioFINDER study, we tested associations between a priori defined polygenic risk scores (PRSs) for AD (excluding single-nucleotide pol

We have developed a method for simultaneous tomosynthesis and mechanical imaging, called DBTMI. Mechanical imaging measures the stress distribution over the compressed breast surface. Malignant tissue is usually stiffer than benign, which results in higher stress on the compressed breast and enables to distinguish malignant from benign findings. By combining tomosynthesis and mechanical imaging, w