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Esophageal perforation in South of Sweden: Results of surgical treatment in 125 consecutive patients

Background: For many years there has been a debate as to which is the method of choice in treating patients with esophageal perforation. The literature consists mainly of small case series. Strategies for aiding patients struck with this disease is changing as new and less traumatic treatment options are developing. We studied a relatively large consecutive material of esophageal perforations in a

Detailed statistical analysis plan for the target temperature management after out-of-hospital cardiac arrest trial

Background: Animal experimental studies and previous randomized trials suggest an improvement in mortality and neurological function with temperature regulation to hypothermia after cardiac arrest. According to a systematic review, previous trials were small, had a risk of bias, evaluated select populations, and did not treat hyperthermia in the control groups. The optimal target temperature manag

Familial risk of venous thromboembolism in first-, second- and third-degree relatives: a nationwide family study in Sweden.

Venous thromboembolism (VTE) clusters in families, but the familial risk of VTE has only been determined in first-degree relatives. This nationwide study aimed to determine the familial risk of VTE in first-, second- and third-degree relatives of affected individuals. The Swedish Multi-Generation Register was linked to Hospital Discharge Register data for the period 1987-2009. This was a case-coho

Health-related quality of life in Swedish children and adolescents with limb reduction deficiency

Aim: To investigate health-related quality of life (HRQoL) in young persons with limb reduction deficiency (LRD). Methods: One hundred and forty children with LRD aged 8-16 answered the DISABKIDS questionnaire for children with chronic health conditions. Of their parents, 137 answered a corresponding questionnaire concerning their child. Results: Compared to reference data from children with other

A Method to Study the Epigenetic Chromatin States of Rare Hematopoietic Stem and Progenitor Cells; MiniChIP-Chip

Dynamic chromatin structure is a fundamental property of gene transcriptional regulation, and has emerged as a critical modulator of physiological processes during cellular differentiation and development. Analysis of chromatin structure using molecular biology and biochemical assays in rare somatic stem and progenitor cells is key for understanding these processes but poses a great challenge beca

G protein-coupled estrogen receptor 1 (GPER) in the female reproductive tract: from physiology to cancer

Popular Abstract in Swedish Östrogen är ett av de viktigaste/ mest studerade kvinnliga könshormonerna som styr utvecklingen av våra fortplantningsorgan och deras reproduktionsförmåga. Östrogen påverkar dessutom många av kroppens andra organ, bland annat hjärnan, skelettet, och hjärt-kärlsystemet. Mängden östrogen som finns i kroppen varierar vanligtvis under menstruationscykeln och med kvinnans ålEstrogen effects are mediated either through genomic action involving the classical estrogen receptors, estrogen receptor alpha (ERα) and beta (ERß), which function as transcription factors in the nucleus, or through rapid non-genomic action via receptors associated with plasma membrane. Recently, a member of the G protein-coupled receptor family was ascribed estrogen receptor properties and propo

A Pilgrimage to the Past : Johannes Bureus and the Rise of Swedish Antiquarian Scholarship, 1600-1650

At the end of the eighteenth century, Edward Gibbon described the antiquarian scholars of previous generations as men of “profound learning and easy faith.” His exemplar was the Swedish polymath Olof Rudbeck, who in a series of frantic and combative tomes sought to portray Sweden as the model for Plato’s Atlantis and the seething cultural cauldron from which Western civilization had emerged. A Pil

A new formulation of the water wave problem for Stokes waves of constant vorticity

We consider steady symmetric gravity water waves on finite depth with constant vorticity and a monotone surface profile between crests and troughs. The problem is transformed into one concerning the vertical velocity. A representation formula for the stream function in terms of the surface and the vorticity is presented, and we show that the surface can be determined from the vertical velocity.

Diagnosis-prescribing surveys in 2000, 2002 and 2005 in Swedish general practice: Consultations, diagnosis, diagnostics and treatment choices

The aim of this study is to present diagnostic patterns, diagnostics used and antibiotic treatment in relation to guidelines in 3 repeated diagnosis-prescription studies conducted simultaneously in general practice in 5 Swedish counties, during 1 week in November 2000, 2002 and 2005. General practitioners (GPs) at the participating health centres were asked to complete a form for all patients with

Hydrogen analysis and profiling with a position sensitive detector

The double sided silicon strip detector (DSSSD) is a segmented silicon detector commonly used in the fields of high energy physics and nuclear physics. This type of detector is used for analysis of reactions produced by charged particles. This makes it well suited for a number of analytical methods commonly used in ion beam analysis (IBA), such as Rutherford Backscattering (RBS) and elastic recoil

Mitochondrial function in sepsis - Temporal evolvement of respiratory capacity in human blood cells

Popular Abstract in Swedish Allt liv på jorden är beroende av energi. Växter och vissa bakterier kan fånga och utnyttja solens energi för att bygga upp sina celler och dess delkomponenter som fetter, sockerarter och proteiner. Den energi som på så sätt blir bunden i dessa molekyler kan användas av djur och människor genom att vi konsumerar dem. För att energin skall kunna utnyttjas av kroppen måstSepsis is a devastating disease that is caused by the host’s response to an overwhelming infectious process. As sepsis progresses, organs distant from the site of infection become affected and sepsis-induced multiple organ failure ensues. An impaired immunologic response, including dysfunctional peripheral blood immune cells has been described as part of the septic syndrome. Mitochondrial dysfunct

Cell-line-specific stimulation of tumor cell aggressiveness by wound healing factors - a central role for STAT3

Background: Local recurrence is a major factor affecting survival after treatment for head and neck squamous cell carcinoma (HNSCC). It is possible that the normal processes involved in wound healing after surgical removal of a primary tumor can boost the regrowth of residual cancer cells, thereby contributing to the recurrent growth. In this work, we collected human wound fluids and used them to

Living Law and Political Stability in Post-Soviet Central Asia : A Case Study of the Ferghana Valley in Uzbekistan

Central Asian countries are facing multidimensional political stability and security challenges in the post-Soviet period. Current scholarly discussions of political stability in post-Soviet Central Asia continue to revolve around the issues of Islamic upheaval, ethnic conflicts, civil war or inter-clan struggles, and how the authoritarian regimes in this region deploy coercive strategies and pena

No title

This thesis explores different aspects of the syntax and discoursepragmatics of predicative anaphors(i.e. proforms and ellipsis)in German and Swedish. The types of anaphoric constructions considered in the analysis are: (i) overt predicative proform expressions, instantiated by the neuter proform "es"/"das" in German and "det" in Swedish, and (ii) covert elliptical instantiations, reminiscent of t

Spasticity of the gastrosoleus muscle is related to the development of reduced passive dorsiflexion of the ankle in children with cerebral palsy A registry analysis of 2,796 examinations in 355 children

Background and purpose Spasticity and muscle contracture are two common manifestations of cerebral palsy (CP). A spastic muscle may inhibit growth in length of the muscle, but the importance of this relationship is not known. In 1994, a register and a healthcare program for children with CP in southern Sweden were initiated. The child's muscle tone according to the Ashworth scale and the ankle ran