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Background: Multiple sclerosis (MS) is an inflammatory, demyelinating disease affecting the central nervous system. Fatigue and impaired information processing speed (IPS) are the most debilitating symptoms of MS. Natalizumab (NTZ) and rituximab (RTX), currently Sweden’s two most-prescribed drugs for MS treatment, are known to almost completely ameliorate clinical and radiological relapse activity

The eyeball is not rigid and deforms during saccades. As a consequence, the saccade waveform recorded by an eye tracker may depend on which structure of the eye is used to estimate eyeball rotation. Here, we systematically describe and compare signals co-recorded from the retina, the cornea (corneal reflection, CR), the pupil, and the lens (fourth Purkinje reflection, P4) during saccades. We found

Global warming is expected to transfer carbon from soil organic matter to atmospheric CO 2, with microbial communities playing a crucial role in regulating this exchange. While the immediate impact of temperature on microbial functions is well understood and causes soil carbon losses, the long-term response remains unclear, with losses stabilising over time, reducing the overall effect of chronic

IntroductionThe evidence for assessing whether a single stab injury to the trunk was inflicted by another person in an assault or self-inflicted has primarily been derived from autopsy studies. In this study, we investigate whether victim demographics, crime scene circumstances, and the injury characteristics of assault survivals are interchangeable with homicide characteristics, with a specific f

Ultrasound optical tomography enables noninvasive characterization of tissue and lesions up to 5 cm below the skin surface, by enhancing diffuse optical tomography with ultrasound focusing resolution and an increased number of measurement points. For optimal clinical imaging, it is essential to be able to reconstruct tissue optical properties in real time during in vivo measurements, and therefore

Purpose: The sugar industry is always pressured to be suitable and enhance its operational effectiveness. Digital Twin (DT) has the potential to transform this industry. However, the lack of industry-specific Key Performance Indicator (KPI) frameworks makes it challenging to implement them. This study provides a hierarchical KPI model for DT adoption in the sugar sector, interconnecting the United

The standard assessment of mental health typically involves clinical interviews conducted by highly trained clinicians. While effective, this approach faces substantial limitations, including high costs, high clinician workload, variability in expertise, and a lack of standardization. Recent progress in large language models (LLMs) offer a promising avenue to address these limitations by simulatin

We investigate whether the eye parameter of bumblebees—a visual trait measuring the tradeoff between light sensitivity and visual resolution—is associated with: (i) local habitats, (ii) forest cover at the landscape scale (1 km radius), and (iii) the shade tolerance of the plants they forage on. The association of bumblebee species with local habitat and forest cover at the landscape scale was ana

Insect pollinators are declining globally, partly due to agricultural intensification, which threatens biodiversity and ecosystem services. To help decision-makers make informed choices, a variety of tools such as softwares, websites and frameworks have been developed to guide pollinator-friendly management and conservation. However, the lack of a comprehensive overview of these tools limits stake

This article explores the complex relationship between performance programs in higher music education and the evolving demands of current and future professional music scenes. Drawing upon career anchor theory and enactive cognitive science, it introduces a workshop-based framework to support students in reflecting on future working life. The framework decenters ideas of entrepreneurship and marke

OBJECTIVE: To evaluate if opioid-free anaesthesia (OFA), is non-inferior to standard of care (SOC), in patients at low risk for acute postoperative pain (APOP).DESIGN: Patient- and assessor-blinded, non-inferiority, randomised, controlled trial.SETTING: Single centre between March 2022 to February 2024.PATIENTS: 154 adult patients, ASA I - II, planned for elective laparoscopic surgery and risk-cla

Disturbances play a key role in forest dynamics globally, with various effects on productivity. Tree diversity is expected to attenuate the negative impact of disturbance on forest productivity, but its overall effect has been little explored and might depend on the functional composition. Here, we analysed whether forest productivity responses to disturbances were modulated by structural and func

The Kunming-Montréal Global Biodiversity Framework, adopted at COP15, establishes a clear mandate to mobilize funding from diverse sources to address the escalating biodiversity crisis. Despite growing awareness and commitment to biodiversity conservation, a substantial financing gap persists, hindering efforts to protect and restore ecosystems effectively. This chapter provides an in-depth examin