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Neuroblastoma is pediatric cancer of the sympathetic nervous system which originates from the trunk neural crest cell population during embryonic development. Clinical representation of neuroblastoma ranges from a spontaneous regression to metastatic disease with only about 50% survival rate. Molecular events which turn normal development of sympathetic nervous system to tumorigenic has not been f
Immunotherapy utilizes the patient’s own immune system for the treatment of cancer. Due to exceptional antigen-presentation capacity Dendritic Cells (DCs) have great potential for cancer immunotherapy. Using direct cellular reprogramming our group has identified a combination of transcription factors, PU.1, IRF8, and BATF3 that reprograms mouse and human fibroblasts and a range of cancer cell line
Bakgrund: Det är vanligt att barn upplever rädsla i samband med besök i hälso- och sjukvården och vid medicinska procedurer. Upp till 45% av barn i åldern 4–6 år känner svår ångest under vaccinering vilket belyser deras oro av nålar och vården. Erfarenheter i form av rädsla, smärta och oro i och vid sjukvårdsbesök kan ha långsiktiga konsekvenser för barnet och i vissa fall kan det leda till nålfob
Since a large growth in population occurred during the 1800-1900 centuries in Sweden, an expansion of agricultural land became a necessity. The government provided farmers with an allowance to exploit wetlands. A large portion of wetlands has since then been lost and used for cultivation, in particular peat lands. The drainage of peat lands results in a loss in biodiversity, poorer water condition
Democracy is a broad and complicated concept with numerous interpretations. To determine people's actual desire for democracy, we must first understand the concept they have in mind. By conducting qualitative interviews with open-ended questions, this study aims to study the in-depth meanings behind the concept of democracy among the young people in Kazakhstan. This study uses an interpretive
Acoustophoresis is a cell separation technology where particles or cells are suspended in a fluid container and subject to acoustic standing waves. The standing waves exerts an acoustic radiation force on the particles, pushing them towards the nodal plane. This movement is called migration, and the migration velocity depends on the acoustic mobility of the particle, which depend on the particle s
Chemicals are becoming more and more important and almost essential for human life. Therefore, the human exposure of hazardous chemicals has increased substantially. Alternative assessment (AA) is a method used for substitution of hazardous chemicals and requirements for substitution are included in European health and safety legislation. As part of Region Kalmar läns environmental and sustainabil
The aim of this project is to design a solution to a payment system for people that have a diagnosis of intellectual disorder. This target group has problems with today’s payment system because it becomes successively more digital. With the digital solutions will the target group be excluded. I have been thinking of the question “What would happen if cash was removed as a payment system?”. I have
In addition to its complex structure, the cerebral cortex has multiple functions exclusive to humans. Unfortunately, it also plays a crucial role in multiple neurodevelopmental and psychiatric disorders. Although we know very little about human-specific gene regulatory mechanisms during brain development, non-coding RNAs are evolutionarily non-conserved, evolve faster, and are highly expressed in
The common way in which algal virus-host systems are discovered is when an algal culture collapses due to the virus-induced lysis. Therefore, the presence of a viral infection in a seemingly healthy culture of Chlamydomonas sp. is an oddity. This study describes such an infection in an algal sample from Örsjön, a lake in southern Sweden, sustained in culture for over six years with no observed adv
Pregnancy is an immunological conundrum as the semi-allogenic fetus is tolerated concurrently as the mother and fetus are protected against pathogens. Systemic and local immunological alterations are a vital part of healthy pregnancy, and a possible contributor to gestational diseases. This study aimed to characterize peripheral, intervillous and decidual maternal immune cells during healthy labor
Parkinson's disease (PD) is a neurodegenerative disease that is characterized by alpha-synuclein (α-syn) aggregations and loss of dopaminergic neurons. The cause for PD is still being researched but neuroinflammation has gained increasing awareness. Polymorphism in class II, major histocompatibility complex, transactivator (Ciita), which regulates major histocompatibility complex II (MHCII) ex
Reducing plastic waste incineration is crucial for Sweden’s transition to a carbon neutral society in 2045. To achieve this goal, it is essential to increase the material recycling of plastics. The availability of recyclable plastics depends on the private individual’s participation in sorting their plastic waste at the municipal recycling centres. Currently, the sorting quality of the rigid plast
Idag återfinns sexistiska kommentarer på sociala medieplattform, trots att företagen bakom har regler för vad som får publiceras. Sexism är ett strukturellt problem som kan påverka kvinnor negativt, både fysiskt och psykiskt och kan leda till självcensur. Ge- nom en kvalitativ textanalys syftar denna uppsats att testa om tre principer kan användas för att analysera om sexistiska kommentarer från FToday, sexist comments can be found on social media platforms, despite social media companies having rules on what is allowed to be published. Sexism is a structural prob- lem which can negatively affect women, both physically and mentally, and could lead to self-censorship. Through a qualitative text analysis, this essay aims to investigate whether sexist comments from Facebook and Instagram are
Energy for heating and cooling purposes is essential for many industrial processes, as well as something we all rely on to provide us with warm water and a pleasant indoor climate. As much as half of all energy consumed in the EU is used for heating and cooling [1]. District heating and cooling grids are common ways in which the energy is delivered and distributed, and due to the large quantities
