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Learning of Parameters in Behavior Trees for Movement Skills

Reinforcement Learning (RL) is a powerful mathematical framework that allows robots to learn complex skills by trial-and-error. Despite numerous successes in many applications, RL algorithms still require thousands of trials to converge to high-performing policies, can produce dangerous behaviors while learning, and the optimized policies (usually modeled as neural networks) give almost zero expla

The role of CART in islet biology

Cocaine- and amphetamine-regulated transcript (CART) is mostly known for its appetite regulating effects in the central nervous system. However, CART is also highly expressed in the peripheral nervous system as well as in certain endocrine cells. Our group has dedicated more than 20 years to understand the role of CART in the pancreatic islets and in this review we summarize what is known to date

Aspects of Complement Activation in Thrombocytopenic Disorders

The complement system is an essential effector of both innate and acquired immune responses. Due to its destructive potential, tight regulation is required. The contribution of complement has been associated with the pathogeneses in a wide range of diseases. In this thesis, aspects of complement activation were investigated in disorders characterized by thrombocytopenia.In papers I and II, clinicaThe complement system is an essential effector of both innate and acquired immune responses. Due to its destructive potential, tight regulation is required. The contribution of complement has been associated with the pathogeneses in a wide range of diseases. In this thesis, aspects of complement activation were investigated in disorders characterized by thrombocytopenia.In papers I and II, clinica

Effect of welding fumes on the cardiovascular system : a six-year longitudinal study

Objective This study investigated whether low-to-moderate exposure to welding fumes is associated with adverse effects on the cardiovascular system.Methods To test this, we performed a longitudinal analysis of 78 mild steel welders and 96 controls; these subjects were examined twice, six years apart (ie, timepoints 1 and 2). All subjects (male and non-smoking at recruitment) completed questionnair

A quantitative LC-MS method to determine surface contamination of antineoplastic drugs by wipe sampling

The main objective was to develop a wipe sampling test to measure surface contamination of the most frequently used antineoplastic drugs (ADs) in Swedish healthcare and, furthermore, to develop an analysis method sensitive enough to assess low levels of contamination. Two wipe sampling tests with separate sample processing methods assessing (i) cyclophosphamide (CP), ifosfamide (IF), 5-fluorouraci

Complications After Thyroid Surgery

Background: Thyroidectomy is a common surgical procedure performed worldwide. Postoperative complications can be life-threatening. Many efforts have been made during the last century to reduce the burden of postoperative complications, with remarkable achievements. However, there are still many patients suffering.Aims: the main aims of the first three studies were to understand risk factors for in

Turismen ger mer än det vi kan mäta

Vi pratar ofta om turismens mätbara nytta, såsom gästnätter eller lokal konsumtion. Men turism bidrar även till många värden som inte alltid går att mäta. För hur ska vi mäta värdet av tillförsikt, av att se möjligheter där man bor eller att känna sig inkluderad?

Patient-reported physical and psychosocial significance of abdominal scarring in anorectal malformations

Background Abdominal scarring in patients with anorectal malformations (ARM) is a permanent visible sign of a chronic congenital condition. The study's aims were to assess the physical and psychosocial significance of abdominal scarring in ARM and to propose a scar treatment approach. Methods A patient- and observer reported cross-sectional study of ARM patients with previous colostomies surgicall

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Fra det syriske voldskaos er der opstået en ny litterær strømning, der er kendetegnet ved at være meget sanselig og kropslig. Død, blod og afrevne lemmer er gennemgående elementer i teksterne, der beskriver, hvordan krigen besætter hverdagen og fører helt nye lugte- og sanseindtryk med sig. Teksterne er et vidnesbyrd om volden og bryder med en litterær tradition i Syrien, hvor censur og afstraffelArticle in Danish on new Syrian literature written after the militarization of the popular uprising. As a consequence of the violence and destruction, this literature is very bodily and full of sense perceptions of the new war reality. The article presents literary examples written by the Syrian poet Rasha Omran and the Syrian novelist, poet, and journalist Khalil Sweileh.

Transient dynamics of a magnetic impurity coupled to superconducting electrodes : Exact numerics versus perturbation theory

Impurities coupled to superconductors offer a controlled platform to understand the interplay between superconductivity, many-body interactions, and nonequilibrium physics. In the equilibrium situation, local interactions at the impurity induce a transition from the spin-singlet to the spin-doublet ground state, resulting in a supercurrent sign reversal (0-π transition). In this work, we apply the

A Children's Health Perspective on Nano- and Microplastics

BACKGROUND: Pregnancy, infancy, and childhood are sensitive windows for environmental exposures. Yet the health effects of exposure to nano- and microplastics (NMPs) remain largely uninvestigated or unknown. Although plastic chemicals are a well-established research topic, the impacts of plastic particles are unexplored, especially with regard to early life exposures.OBJECTIVES: This commentary ai

Be Aware of the Indoor Air. Physicochemical Characterization of Airborne Fine Particles in Occupied Homes : Physicochemical Characterization of Airborne Fine Particles in Occupied Homes

Negative health effects of exposure to particles of outdoor origin have been confirmed by epidemiological studies. In developed countries, we spend on average 65% of our time in our homes. Thus, the properties of airborne particles indoors need to be understood. The aim of this PhD thesis was to investigate the differences in physicochemical and toxicological characteristics of fine particles (PM2.5

Genetic and environmental influences on the progression from alcohol use disorder to alcohol-related medical conditions

Background: Medical conditions related to alcohol use disorders (AUD) represent a substantial public health concern. However, only a subset of individuals with AUD develop these conditions and the extent to which genetic and environmental factors that are shared with AUD, versus those distinct from it, contribute to this progression has not yet been determined. Methods: Using data from Swedish nat

Diet and lifestyle behaviour disruption related to the pandemic was varied and bidirectional among US and UK adults participating in the ZOE COVID Study

Evidence of the impact of the COVID-19 pandemic on health behaviours in the general population is limited. In this retrospective longitudinal study including UK and US participants, we collected diet and lifestyle data pre-pandemic (896,286) and peri-pandemic (291,871) using a mobile health app, and we computed a bidirectional health behaviour disruption index. Disruption of health behaviour was h

Exploring the Associations Among Occupational Balance and Health of Adults With and Without Inflammatory Arthritis

Objective: Occupational balance is a person's subjective perception of the amount and variation of their everyday activities. Evidence suggests an association between occupational balance and health. However, the impact of arthritis on occupational balance and its association with health is unclear. This exploratory study was undertaken to examine associations between occupational balance and meas

Lose pain, lose weight, and lose both : A cohort study of patients with chronic pain and obesity using a national quality registry

Background: It is known that chronic pain makes it difficult to lose weight, but it is unknown whether obese patients (body mass index ≥30 kg/m2) who experience significant pain relief after interdisciplinary multimodal pain rehabilitation (IMMPR) lose weight. Objective: This study investigated whether obese patients with chronic pain lost weight after completing IMMPR in specialist pain units. Th

A Scenario Analysis of the Potential Effects of Decarbonization on the Profitability of the Energy-Intensive and Natural-Resource-Based Industries

The decarbonization of the energy-intensive and natural-resourced-based industries is associated with large economic costs. In this paper, I explore how decarbonization may affect the profitability and market value of these industries and their ability to attract capital to fund their decarbonization. I also discuss the possibility of compensating for the investment costs through higher prices and