OBJECTIVE: To estimate the incremental cost-effectiveness of infliximab versus conventional combination treatment over 21 months in patients with methotrexate-refractory early rheumatoid arthritis. METHODS: In this multicentre, two-arm, parallel, randomised, active-controlled, open-label trial, rheumatoid arthritis patients with

An exploratory study of a train evacuation inside a tunnel was performed in order to study the effects of different train exit configurations on the flow rate of people through the exit. A total of 84 participants in the ages 18–40 years took part in the experiment, which was carried out on two separate days and involved 18 evacuation scenarios. The statistical analysis of the experiment demonstra

Context: Our aim was to present a summary of the Second International Consultation on Bladder Cancer recommendations on the diagnosis and treatment options for non-muscle-invasive urothelial cancer of the bladder (NMIBC) using an evidence-based approach. Objective: To critically review the recent data on the management of NMIBC to arrive at a general consensus. Evidence acquisition: A detailed Med

The structuring of quantitative genetic variation can have a significant impact on the adaptive potential and long-term viability of species in changing landscapes. The present study of the grass Briza media investigated the relationships between patterns of heritable variation in phenotypic characters and descriptors of landscape structure, land-use history and local habitat conditions in a lands

Rhaphidicyrtis trichosporella (Nyl.) Vain. is reported here as new to Sweden from five sites in the southernmost part of the country, two in the province of Skåne and three in Småland. All sites are deciduous woodlands of different composition, but most likely with a long ecological continuity. Two records are from scaling bark of Alnus glutinosa in Alnus swamps, two from hard and smooth bark of F

The Kruppel-like protein ZNF224 is a co-factor of the Wilms' tumor 1 protein, WT1. We have previously shown that ZNF224 exerts a specific proapoptotic role in chronic myelogenous leukemia (CML) K562 cells and contributes to cytosine arabinoside-induced apoptosis, by modulating WT1-dependent transcription of apoptotic genes. Here we demonstrate that ZNF224 gene expression is down-regulated both in

A measurement of the total pp cross section at the LHC at root s = 7 TeV is presented. In a special run with high-beta* beam optics, an integrated luminosity of 80 mu b(-1) was accumulated in order to measure the differential elastic cross section as a function of the Mandelstam momentum transfer variable t. The measurement is performed with the ALFA sub-detector of ATLAS. Using a fit to the diffe

Background: Bioethanol produced from the lignocellulosic fractions of sugar cane (bagasse and leaves), i.e. second generation (2G) bioethanol, has a promising market potential as an automotive fuel; however, the process is still under investigation on pilot/demonstration scale. From a process perspective, improvements in plant design can lower the production cost, providing better profitability an

Popular Abstract in English Colorectal cancer (CRC) is a cancer caused by uncontrolled cell growth in colon or rectum. CRC is the third most common cancer and the fourth leading cause of cancer related death in the world. It is a multifactorial disease, both genetic predisposition and environmental play a role in the development of CRC. CRC is closely linked to chronic inflammation. Patients with Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of death from cancer worldwide. People suffering from inflammatory bowel disease, such as Crohns’ disease and ulcerative colitis, are at an increased risk of developing CRC. The development of CRC is highly influenced by the tumour microenvironment. Tumour cells are able to recruit macrophages and change their beh

Permanent exposure to pathogens requires decisions toward tolerance or immunity as a prime task of dendritic cells. The molecular mechanisms preventing uncontrolled immune responses are not completely clear. We investigated the regulatory function of Ncf1, an organizing protein of NADPH oxidase, in the signaling cascade of Toll-like receptors. TLR9-stimulated spleen cells from both Ncf1-deficient

Different stakeholders involved in the software development may attribute success to different indicators. Analogously they may support different factors considered the root of successful projects. The study presented in this paper explores how different stakeholders perceive project success and what they deem the effect of specific factors on the project outcome. The study highlighted both common

Basal ecosystem respiration rate (BR), the ecosystem respiration rate at a given temperature, is a common and important parameter in empirical models for quantifying ecosystem respiration (ER) globally. Numerous studies have indicated that BR varies in space. However, many empirical ER models still use a global constant BR largely due to the lack of a functional description for BR. In this study,

We prove a T(1) theorem to completely characterize compact Calderon-Zygmund operators. The result provides sufficient and necessary conditions for the compactness of singular integral operators acting on L-p(R) with 1 < p < infinity. (C) 2015 Elsevier Masson SAS. All rights reserved.