The clinical success of targeted cancer therapies is limited by the emergence of drug resistance often due to pre-existing tumor genetic heterogeneity and acquired, therapy-induced resistance. Targeted therapies have varied success in addressing metastatic disease, due to their ability to penetrate certain physiological compartments. This paper considers an evolutionary cancer model that incorpora

I centrum för denna sammanläggningsavhandling, som består av sex artiklar och ett introduktionskapitel, står koncepten ekologisk skuld, klimatskuld, ekologiskt ojämnt utbyte och ojämn appropriering av kolsänkor. Begreppens idéhistoria och politiska historia spåras bakåt till miljörättviserörelsen, ekologisk ekonomi och neo-marxistisk ekonomi. De utvecklas konceptuellt och länkas samman analytiskt In this compilation thesis, consisting of six papers and an introductory chapter, the concepts of ecological debt, climate debt, ecologically unequal exchange, and unequal carbon sink appropriation are at the centre. Their intellectual and political histories are traced to environmental justice movements, ecological economics and neo-Marxist economics. They are developed conceptually and linked to

Crosses between closely related animal species often result in male hybrids that are sterile, and the molecular and functional basis of genetic factors for hybrid male sterility is of great interest. Here, we report a molecular and functional analysis of HMS1, a region of 9.2 kb in chromosome 3 of Drosophila mauritiana, which results in virtually complete hybrid male sterility when homozygous in t

This paper serves as an overview to the special session Circuits and Systems for 5G on IEEE International Conference on ASIC (ASICON) 2015. More specifically, we introduce two of enabling technologies for the coming 5G wireless era, namely massive multiple-input multiple-output (MIMO) technique and advanced coding techniques such as polar codes. Massive MIMO is a relatively new wireless communicat

Photoinduced degradation of individual methylammonium lead triiodide (MAPbI3) perovskite nanocrystals was studied using super-resolution luminescence microspectroscopy under intense light excitation. The photoluminescence (PL) intensity decrease and blue-shift of the PL spectrum up to 60 nm together with spatial shifts in the emission localization position up to a few hundred nanometers were visua

”Seeing is believing” är ett koncept fött ur människans oändliga nyfikenhet att veta mer. Otvivelaktigt så har modern vetenskap vuxit fram ur denna naturliga strävan efter att vilja veta mer. Från ett tidigt stadium har mikroskopi varit en hörnsten i många vetenskapsdiscipliner. Redan i ett tidigt skede filosoferade mikroskopister kring vad de minsta beståndselarna av naturen är och om vi ens kan Optical microscopy is a fundamental tool in a range of disciplines encompassed by the physical and biological sciences. At the dawn of this millennium, a break-through was made in optical microscopy where super-resolution methods emerged and declared imaging beyond the optical diffraction limit a possibility. Most of these methods are based on fluorescence detection of single molecules. These meth

Many of the established Swedish crime writers write for both adults and young readers. These authors are successful in the two literary market segments that are dominating the contemporary Swedish book market: crime literature and children’s literature. Can certain developed trademarks in their authorship for adults be used in order to market books for other age groups and to what extent do the au

The area around the villages Kvarnby and Södra Sallerup in south-west Scania is the only known flint-mining site in Sweden. Radiocarbon dates show that the flint was mined mainly during the earliest phase of the Early Neolithic, between c. 4000 and 3600 BC, thus coinciding with the earliest evidence of the Funnel Beaker Culture in the region. The type of flint, the size of the flint nodules, produ

PurposeThe purpose of this paper is to differentiate human responses to different light switch designs to determine the effects of these common interfaces on user perceptions and use of electric lighting in public buildings.Design/methodology/approachEmpirical studies were conducted to assess and examine user perceptions with regard to design characteristics of light switches, and occupants’ use o

The relationship between environment and migration has gained increased attention since the 1990s when the Intergovernmental Panel on Climate Change projected climate change to become a major driver of human migration. Evaluations of this relationship include both quantitative and qualitative assessments. This review article introduces the concept of scale to environment-migration research as an i

BACKGROUND: Severe obesity in adolescence is associated with reduced life expectancy and impaired quality of life. Long-term benefits of conservative treatments in adolescents are known to be modest, whereas short-term outcomes of adolescent bariatric surgery are promising. We aimed to compare 5-year outcomes of adolescent surgical patients after Roux-en-Y gastric bypass with those of conservative