To simulate the human situation concerning human monoclonal antibodies (MAbs), we have introduced a new syngenic rat model with an implanted rat colon carcinoma. Rat IgM MAbs (10B12), labelled by the chloramine-T method with 125I or internally with 35S, were injected intravenously into the rats and the biodistribution was studied for 8 days. The radioactivity uptake in the tumours of the 35S label

Purpose: The present study describes the prevalence of visual impairment and blindness in a geographically defined population 8 years after the introduction of a screening programme in 1987 for early detection of sight-threatening diabetic retinopathy. Methods: Of 374 patients with diabetes, comprising 2.6% of the population in the study community, 72% were examined with fundus photography or bio

OBJECTIVES: To evaluate the health-related quality of life (HRQL) of patients with head and neck cancer during and after treatment with radiotherapy, surgery, and chemotherapy. STUDY DESIGN: Prospective, descriptive study. METHODS: All new patients in four institutions in Norway and Sweden were asked to participate. Health-related quality of life was assessed at baseline and at 1, 2, 3, 6, and 12

Abstract is not available.

A group of patients (n=69) were asked to arrange the three most important of 10 groups of needs, identified by patients in a previous study, in order of priority from one to three. A group of nurses (n=89) were asked to arrange same groups of needs in order of priority from one to three according to how they believed patients would rank them. No significant differences were found between patients

This paper presents and analyses autumn migration data on phenology and biometrics for 12 species of birds trapped at the Capri Bird Observatory, south-western Italy. The material has been collected over 15 years, mainly in two periods, 1959-1963 and 1994-2004. The passage of trans-Saharan migrants (like the Garden Warbler Sylvia borin) peaks in late September and these birds generally carry moder

Modernitet och intermedialitet is the first major study of the Swedish modernist writer Erik Asklund (1908-1980) and his works. The thesis consists of an introductory chapter and three close readings of Asklund’s early novels Kvinnan är stor (The Woman is Great, 1931), Lilla land (A Small Country, 1933), and Fanfar med fem trumpeter (A Fanfare with Five Trumpets, 1934). In these novels, Asklund de

This thesis treats different aspects of automotive control-systems and consists of four papers covering different areas in this large field. The first paper presents a 9-degrees-of-freedom dynamic model of a tractor-semitrailer vehicle, aimed at simulation and evaluation of active chassis-systems for stability enhancements. Special focus is put on inclusion of the dynamics of load transfer, which

Vår utgångspunkt är den nya kursen »Individ och samhälle« på den reformerade läkarutbildningens avslutande termin. Som lärare betonar vi vikten av att kompetensmål, arbetsformer och examination hänger samman på ett klart och tydligt sätt, så att de studerande styrs rätt i sitt lärande. Som studerande lyfter vi fram förutsättningarna för en aktiv studerandemedverkan: att involveras medan möjlighet

Fire and flame spread are very complex phenomenon to study. Several aspects need to be considered and treated. In order to be able to do a correct analysis of the flame spread phenomenon, which is necessary to be able to predict flame spread, knowledge of material properties are needed. Material properties can be obtained in different ways. Traditionally material data have been obtained by testin

Popular Abstract in Swedish Delarbetena i denna avhandling, som baseras på en befolkningsstudie från Malmö, studerar sjuklighet och dödlighet associerad till rökning och kroniska luftrörssjukdomar med hänsyn till köns och socioekonomiska aspekter. Studier av män har övertygande visat en ökad mortalitetsrisk associerat med tobaksrökning. Emellertid har endast ett fåtal studier undersökt långtidsefThe Malmö Preventive Project, a preventive, case-finding programme for cardiovascular risk factors and alcohol abuse was created in 1974 at the Department of Preventive Medicine of Malmö University Hospital. Between 1974-1992, a total of 22 444 men (mean age 44 years range 27 - 61) and 10 902 women (mean age 50 years, range 28 - 58) attended the programme, with an overall attendance rate of 70% (r

The mechanisms behind the long duration of bronchodilating action of the beta 2-adrenoceptor agonists formoterol and salmeterol are only partially understood. This review compares pharmacological characteristics of long-acting versus short-acting beta 2-adrenoceptor agonists in human and animal airways. Based upon the reviewed evidence, it is concluded that for beta 2-adrenoceptor agonists, long d

The purpose of this study was to investigate public grants for housing adaptation in modern housing and to explore attitudes to accessibility problems. Grants for housing adaptation in apartments in blocks of flats built during the 1980s in a Swedish urban district were investigated over a 3-year period. Twenty-nine apartments had been adapted, in most cases by making a few simple alterations. Int

The thiazolidinediones were introduced as oral hypoglycemic drugs in Sweden during the fall of 2000. A case is reported in which a woman with insulin-dependent type-2 diabetes and both macro- and microangiopathy and pronounced insulin resistance was treated with rosiglitazone (Avandia). Within three months insulin doses could be reduced by 36% (from 176 to 112 units insulin daily) and concomitantl

Suitable conditions for separating cells using a chromatographic procedure were evaluated in parallel chromatography on minicolumns. A 96-hole minicolumn plate filled with cryogel monoliths (18.8 mm x 7.1 mm O) with immobilized concanavalin A was used. Chromatographic columns (113 mm x 7.1 mm O) were used for chromatographic resolution of a mixture of Saccharomyces cerevisiae and Escherichia coli