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Popular Abstract in Swedish Förekomsten av sjukdomar inom det sk metabola syndromet (typ 2 diabetes, insulinresistans, övervikt, högt blodtryck och hjärt-kärlsjukdomar) ökar kraftigt i västvärlden. En viktig faktor för utvecklandet av detta syndrom är en försämrad insulinkänslighet. När kroppen utsätts för kontinuerligt höga insulinnivåer försämras känsligheten för detta hormon vilket resulterar iThe metabolic syndrome (type 2 diabetes, obesity, hypertension, atherosclerotic cardiovascular disease, dyslipidaemia, and hyperinsulinaemia), is increasing in prevalence world-wide. The progression of this syndrome proceeds through a step-wise deterioration of metabolic events where deterioration of insulin sensitivity appears to have a key role in a ?vicious circle? of hyperinsulinaemia/hypergly

Changes in hydrology and temperature can induce rapid changes in boreal wetland ecosystems. Factors such as hydrosere, permafrost, climate and human interference may disturb the prevailing mire vegetation, whereby a new dominant assemblage can develop. At the transition from one vegetation type to another, the old vegetation may be suppressed, die out or start to decay, and some time may pass unti

A new generalized bimodal traffic stream model deriving theoretically (i.e., via some underlying model of driver behavior) from (local) equilibrium solutions of a kinetic equation of vehicular traffic is presented and shown to have the correct flow behavior at jam density. This bimodal traffic stream model depends not only on parameters such as the desired speed w, the headway σ(0) at jam density

Från humlor, metanbomber och luftpartiklar till markkonflikter och klimatanpassning på medborgarnivå. Klimatförändringen och dess konsekvenser blir alltmer tydlig och sträcker sig allt längre in i samhällsfrågorna och vardagslivet. Klimatfrågan handlar dels om naturvetenskapliga frågeställningar, om atmosfärsprocesser och förändringar i havet och på tundran, och om naturresurser och tjänster som v

The topic of this thesis is dynamics and wear of structures. In the six appended papers different aspects of wear and dynamics of a model system are studied. The considered system consists of a long slender rod with unilateral supports, subject to harmonic and stochastic excitation. The rod is held at one end with stiff springs preventing translation and rotation and constrained by loose sup

Abstract Work on the design, synthesis, and biological evaluation of galectin inhibitors is presented. The most significant results relate to the development of galactose-based arginine “tweezers” and taloside-based galectin inhibitors. The galectins are a β-galactoside binding protein family. They are involved in cancer and inflammation, thus comprising interesting pharmaceutical targets. Galact

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Roman glass from indigenous sites is a key source material for studying the impact of Rome on Iron Age Scotland, but it has never been properly studied. This work fills that gap. This study is based on the Roman glass vessels found on non-Roman/native sites north of Hadrian’s Wall, dated mainly to the Roman Iron Age (AD 10-400 AD). These often-overlooked broken sherds of glass are shown to be pa