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Nateglinide Improves Early Insulin Secretion and Controls Postprandial Glucose Excursions in a Prediabetic Population.
OBJECTIVE—The purpose of this study was to evaluate the metabolic effectiveness, safety, and tolerability of nateglinide in subjects with impaired glucose tolerance (IGT) and to identify a dose appropriate for use in a diabetes prevention study. RESEARCH DESIGN AND METHODS—This multicenter, double-blind, randomized, parallel-group, fixed-dose study of 8 weeks’ duration was performed in a total of
Quantification of ovarian power Doppler signal with three-dimensional ultrasonography to predict response during in vitro fertilization
OBJECTIVE: To evaluate whether power Doppler predicts ovarian response to gonadotrophin stimulation during in vitro fertilization (IVF). METHODS: Forty-five women were divided into low-reserve (n = 12) and normal-reserve (n = 33) ovarian groups, according to antral follicle count. Transvaginal three-dimensional power Doppler ultrasonographic examinations were performed after pituitary downregulati
Excess radiation absorbed doses from non-optimised radioiodine treatment of hyperthyroidism.
A variational approach to the stability of periodic peakons
The peakons are peaked traveling wave solutions of an integrable shallow water equation. We present a variational proof of their stability.
Diffusion rates in a dense matrix of methane-producing microorganisms
The diffusion rate of a species, in a dense matrix of methane-producing microorganisms, was determined experimentally. To this end, a specially designed diaphragm diffusion cell was utilized. The experimental results revealed that the effective diffusion coefficient in a microorganism matrix was 22–33% of the diffusion coefficient in pure water.
Multiple risk intervention trial in high risk hypertensive men: comparison of ultrasound intima-media thickness and clinical outcome during 6 years of follow-up
OBJECTIVES: The objective was to analyse whether a favourable change in risk factors, caused by a comprehensive risk factor modification programme, affected intima-media thickness (IMT) in the common carotid artery, and whether any such change was associated with a change in cardiovascular events during a 6-year follow-up. DESIGN: Patients were randomized 1 : 1 to special intervention or usual car
Evaluation of a Probing Feeding Strategy in Large Scale Cultivations
This report presents the results of two \emph{Escherichia~coli} cultivations performed in a large scale industrial bioreactor. The experiments aimed at evaluating a probing feeding strategy that adresses the problem of acetate accumulation. The principle is to superimpose short pulses in the glucose feed and evaluate the response in the dissolved oxygen signal for the feed adjustments. Simulations
A short guide to the theory of the sublime
The article concerns selected important issues of poetics and its history. The authors analyze and interpret the history of the notion of the sublime. The article is an introduction to a theoretical part of a book about a possible theory of the literary work of art and communication that results from the experience of the sublime. The introductory article presents to the reader questions which are
Measurements of water vapour sorption in wood. Part 2. Results
Results from sorption measurements at 23 °C on Picea abies in the intervals 54 to 75% RH and 75 to 84% RH are reported. In the higher interval non-Fickian sorption is clearly seen.
Supercritical Fluids as Alternative, Safe, Food-Processing Media: An Overview.
The continuous growth of world population and its concentration in the urban areas require food supplies that are continuous, sufficient and of good quality. To resolve this problem techniques have been developed for increasing food quantity and quality. The techniques are applied throughout the food chain from production, conservation and during distribution to the consumers (from "the field to t
Resistens mot acetylsalicylsyra - klinisk diagnos utan klarlagd mekanism
A review on the subject of aspirin resistance and its role in vascular diseases is presented. Although the clinical diagnosis of aspirin resistance is frequently made, little is known about its biochemical background. Only a few follow-up studies, with varying design, have dealt with the possible association between an aspirin resistant phenotype and clinical outcome in patients with atherothrombo
Study of the role of functional variants of SLC22A4, RUNX1 and SUMO4 in systemic lupus erythematosus
Background: Functional polymorphisms of the solute carrier family 22, member 4 (SLC22A4), runt related transcription factor 1 (RUNX1) and small ubiquitin- like modifier 4 (SUMO4) genes have been shown to be associated with several autoimmune diseases. Objective: To test the possible role of these variants in susceptibility to or severity of systemic lupus erythematosus (SLE), on the basis that com
5-(2 '-oxoheptadecyl)-resorcinol and 5-(2 '-oxononadecyl)-resorcinol, cytotoxic metabolites from a wood-inhabiting basidiomycete
5-(2'-oxoheptadecyl)-resorcinol (1) and 5-(2'-oxononadecyl)-resorcinol (2) were isolated from fermentations of an imperfect basidiomycete. The structures of the compounds were determined by spectroscopic techniques. Both compounds exhibit cytotoxic effects against the human colon tumor cell lines COLO-320, DLD-1 and HT-29 and the human promyeloid leukemia cell line HL-60, the human leukemia T cell
Clinical decision-making during 5 years of antipsychotic treatment
Objective: Explore how clinicians select drug treatment based on symptoms, side effects and patient factors, including patient participation in the process, and the association between these factors and attitudes towards drugs. Method: A cohort of 166 patients initially treated with risperidone was followed with yearly assessments over 5 years. At the end of the study, 101 patients were evaluated
Insulin induced phosphorylation and activation of the cGMP-inhibited cAMP phosphodiesterase in human platelets
Insulin induced phosphorylation and activation of the cGMP inhibited cAMP phosphodiesterase (cGI-PDE) in human platelets were demonstrated after isolation of the enzyme with specific polyclonal cGI-PDE antibodies. The demonstration of this insulin effect required suppression of basal cGI-PDE phosphorylation, through the use of the protein kinase inhibitor H-7 (1-(5-isoquinolinylsulfonyl)-2-methylp
Survival in patients with type 2 diabetes in a Swedish community: skaraborg hypertension and diabetes project.
Modeling of a viscous fluid percolating a porous material due to capillary forces
In this report, the percolation of a fluid into a porous material is modeled by using a mixture theory defined within modern continuum mechanics
Intact stones or fragments? Potential pitfalls in the imaging of patients after biliary extracorporeal shock wave lithotripsy
Ultrasound is used after extracorporeal shock wave lithotripsy of gallbladder stones to assess fragmentation. In many patients with apparently successful fragmentation, the posttreatment studies show an intraluminal, echogenic focus within the gallbladder, with posterior acoustic shadowing characteristic of an intact stone. Cholesterol gallstones were fragmented in vitro by means of lithotripsy, a
New scale factors for harmonic vibrational frequencies using the B3LYP density functional method with the triple-xi basis set 6-311+G(d,p)
We have calculated optimal frequency scaling factors for the B3LYP/ 6-311+G(d,p) method for fundamental vibrational frequencies on the basis of a set of 125 molecules. Using the new scaling factor, the vibrational frequencies calculated with the triple-zeta basis set 6-311+G(d,p) give significantly better accuracy than those calculated with the double-zeta 6-31G(d) basis set. Scale factors were al