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The human-specific bacterial pathogen Neisseria meningitidis is a major cause of sepsis and/or meningitis. The pili of N. meningitidis interact with CD46, a human cell-surface protein involved in regulation of complement activation. Transgenic mice expressing human CD46 were susceptible to meningococcal disease, because bacteria crossed the blood-brain barrier in these mice. Development of disease
Excited state properties of fluorobenzene, chlorobenzene, bromobenzene, and iodobenzene have been investigated theoretically using multireference CASSCF and CASPT2 methods. Experimentally, chlorobenzene and bromobenzene are known to exhibit one fast dissociation channel, whereas iodobenzene exhibits two fast dissociation channels. The calculations indicate that the chlorobenzene, the bromobenzene,
Objectives To reanalyze randomized controlled trials on the use of umbilical artery Doppler velocimetry in high-risk pregnancies and determine which high-risk pregnancies benefit from the use of Doppler velocimetry, Methods Searching Medline, the Cochrane Library and Embase we found 13 randomized controlled trials on the use of Doppler velocimetry in high-risk pregnancies. Of these, six included p
In this paper, we report the results of a systematic study of the elastic properties of nanosized single-crystal wires and beams of bcc iron. Both tensile and bending stiffnesses have been determined employing molecular statics simulations for specimens of different sizes and three different crystallographic orientations. We also analyze the influence of circular cross sections and rounded edges c
Several genome sequencing projects have recently been completed and the majority of human coding regions have been sequenced. In the next step many of the further studies will concentrate on proteins. Proteomics methods are essential for studying protein expression. activity, regulation and modifications. Bioinformatics is an integral part of proteomics research. The recent developments and applic
Presents an approach to improved performance and flexibility in industrial robotics by means of sensor integration and feedback control in task-level programming and task execution. Also presents feasibility studies in support of the ideas. Discusses some solutions to the problem using six degrees of freedom force control together with the ABB S4CPlus system as an illustrative example. Consider va
An intramolecular NEMO potential is presented for the N-formylglycinamide molecule together with an intermolecular potential for the N-formylglycinamide-water system. The intramolecular N-formylglycinamide potential can be used as a building block for the backbone of polypeptides and proteins. Two intramolecular minima have been obtained. One, denoted as C5, is stabilized by a hydrogen bonded five
Popular Abstract in Swedish Att fasta under ramadan är både en glädje och ett jihad för det muslimska samfundet i Java, och fastan är utan tvekan den mest aktade ritualen i det muslimska Indonesien (och på andra håll i den muslimska världen). Att avhålla sig från mat, dryck och sexuella relationer från gryning till skymning i en hel månad i ett tropiskt klimat - och att fylla nätterna med extra frFASTING DURING THE holy month of Ramadan is both a joy and a jihad for the Islamic community in Java, and it is arguably the most highly esteemed Muslim ritual in Indonesia (and beyond). To be given the opportunity to abstain from food, drink and sexual relations from the early morning hours until sunset during an entire month in a tropical climate - only to fill the nights with additional and sup
Background: The 39 item Parkinson's disease questionnaire (PDQ-39) is the most widely used patient reported rating scale in Parkinson's disease. However, several fundamental measurement assumptions necessary for confident use and interpretation of the eight PDQ-39 scales have not been fully addressed. Methods: Postal survey PDQ-39 data from 202 people with Parkinson's disease (54% men; mean age 70
Enhancement of anaerobic digestion of sewage sludge by enzyme addition was demonstrated in batch digestion tests. A pre-hydrolysation step with addition of enzymes at controlled temperature during 4 hours was shown to increase the methane yield significantly. Further tests with direct feeding of enzymes together with fresh sludge to the digester gave the same effect of a methane yield increase. Fo
Tidskriftsnummer med fyra artiklar och 19 recensioner.
The evolution of dispersal was investigated in an adaptive individual-based metapopulation model, which allowed for demographic and environmental stochasticity. The individual dispersal behaviour was determined by a one-locus genotype subjected to simple inheritance and mutation. Dispersal behaviour could therefore evolve through the genotype–phenotype mapping and the selection regimes stemming fr
Background: Upper limb disorders (ULDs) are common, and so are the difficulties in specific diagnoses of these disorders. Prior studies have shed light on the nerves in the diagnostic approach beside disorders related to muscles, tendons and joints (MCDs). Objective: The study aimed to compare the distribution of upper limb disorders, and the vibration perception threshold (VPT) in different diagn
Apolipoprotein E (apoE) is a protein involved in transport of lipids and has been implicated to play an important role in regeneration after nerve injury. Determination of apoE in cerebrospinal fluid (CSF) thus have a potential interest when studying different forms of brain damage and as a marker of ongoing regenerative processes in the brain. However, previous studies on CSF-ApoE in Alzheimer's
Of the approximately 15 laminin trimers described in mammals, laminin-1 expression seems to be largely limited to epithelial basement membranes. It appears early during epithelial morphogenesis in most tissues of the embryo, and remains present as a major epithelial laminin in some adult tissues. Previous organ culture studies with embryonic tissues have suggested that laminin-1 is important for e
Thirty-eight women undergoing augmentation mammaplasty, consecutively operated on at the Department of Plastic and Reconstructive Surgery, Malmo, Sweden, were studied preoperatively regarding medical history, personality, psychosocial and psychiatric characteristics. Thirty-six of these patients were interviewed one year postoperatively. Thirty-three age-matched women operated on with minor surgic
Background: Little is known about women's perceptions of their daily life before and after a myocardial infarction (MI), especially with regard to stress, which is a risk factor for coronary heart disease (CHD). Aim: To describe and explore women's perceptions of stress before and after an MI. Method: Two interviews with women who suffered an MI, the first at the hospital (n = 20) and the second 4
