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Thermal unfolding of small proteins with SH3 domain folding pattern

The thermal unfolding of three SH3 domains of the Tec family of tyrosine kinases was studied by differential scanning calorimetry and CD spectroscopy, The unfolding transition of the three protein domains in the acidic pH region can be described as a reversible two-state process. For all three SH3 domains maximum stability was observed in the pH region 4.5 < pH < 7.0 where these domains unfold at

Fetal electrocardiogram: ST waveform analysis in intrapartum surveillance

ST waveform analysis of fetal electrocardiogram (ECG) for intrapartum surveillance (STAN) is a newly introduced method for fetal surveillance. The purpose of this commentary is to assist in the proper use of fetal ECG in combination with cardiotocography (CTG) during labour. Guidelines and recommendations concerning CTG and ST waveform interpretation and classification are stated that were agreed

Towards integration of use case modelling and usage-based testing

This paper focuses on usage modelling as a basis for both requirements engineering (RE) and testing, and investigates the possibility of integrating the two disciplines of use case modelling (UCM) and statistical usage testing (SUT). The paper investigates the conceptual framework for each discipline, and discusses how they can be integrated to form a seamless transition from requirements models t

Exorcisten återvänder

Essä om Exorcisten (1973) - publikmottagandet, filmkritiken och eftermälet samt om den nya Director's Cut-versionen som fick biopremiär 2001.

Vegetation index trends for the African Sahel 1982-1999

[1] Pathfinder AVHRR NDVI data have been analyzed for the African Sahel to study recent trends in vegetation greenness. A strong increase in seasonal NDVI was observed over large areas in the Sahel during the period 1982-1999. The increase is interpreted as a vegetation recovery from the drought periods of the 1980's. Although strong shifts in satellite overpass times have led to shifting solar ze

Survival strategies of the human respiratory tract pathogen Haemophilus influenzae

Haemophilus influenzae is an important respiratory tract pathogen responsible for a variety of infections in humans. Encapsulated H. influenzae belongs to one of six serotypes (a-f), of which type b is the most virulent one causing serious and sometimes life-threatening diseases (e.g., epiglottitis, septicaemia and meningitis). In contrast, non-typeable H. influenzae (NTHi) accounts for the majori

Slalom encodes an adenosine 3'-phosphate 5'-phosphosulfate transporter essential for development in Drosophila.

Sulfation of all macromolecules entering the secretory pathway in higher organisms occurs in the Golgi and requires the high-energy sulfate donor adenosine 3'-phosphate 5'-phosphosulfate. Here we report the first molecular identification of a gene that encodes a transmembrane protein required to transport adenosine 3'-phosphate 5'-phosphosulfate from the cytosol into the Golgi lumen. Mutations in

A low-phase-noise low-phase-error 1.8 GHz quadrature CMOS VCO

A low-phase-noise low-phase-error 1.8 GHz quadrature CMOS VCO was presented. The VCO with three metal layers showed -140 dBc/Hz or less phase noise across an 18% tuning range while drawing 25 mA from a 2 V power supply. The VCO showed high phase-noise figure-of-merit and low phase-error.

Effect of clay modifier and matrix molar mass on the structure and properties of poly(ethylene oxide)/Cloisite nanocomposites via melt-compounding

The present study is concerned with the preparation and characterisation of PEO/clay nanocomposites via melt-extrusion. Two different matrix molar masses of PEO were investigated as well as various types of the Cloisite clay range. PEO/Cloisite Na+ nanocomposites give rise to intercalated structures displaying only a moderate improvement of the mechanical properties at higher clay concentrations,