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Rapid, reliable diagnosis of tuberculosis is essential to initiate correct treatment, avoid severe complications, and prevent transmission. Conventional microbiological methods may not be an option if samples are formalin-fixed and paraffin-embedded (FFPE) for histopathological examination. With the demonstration of necrotizing granulomatous inflammation, tuberculosis becomes an important differen

Denna rapport omfattar analys av klimat i rum som värms och ventileras med luftburen värme. Oberoende av utomhustemperatur och inre belastningsvariationer ska ett inomhusklimat åstadkommas som ger brukarna komfort i vistelsezonen. Syftet med arbetet är att ta fram en beräkningsmetod. Denna ska användas för att teoretiskt utreda om det finns någon donplacering som är bättre än andra ur termisk, hyg

We propose time-frequency domain methods for noise estimation and speech enhancement. A speech presence detection method is used to find connected time-frequency regions of speech presence. These regions are used by a noise estimation method and both the speech presence decisions and the noise estimate are used in the speech enhancement method. Different attenuation rules are applied to regions wi

The laser-induced incandescence technique (LII) is a laser-based diagnostic technique for measurements of soot volume fraction and particle size. The technique relies on detection of incandescent light from soot particles heated to around 4000 K using nanosecond laser pulses. A theoretical model for LII has been implemented and improved in order to provide a tool for predicting the signal respons

PURPOSE: Vagus nerve stimulation (VNS) is a neurophysiologic treatment for patients with refractory epilepsy. There is growing evidence of additional quality of life (QOL) benefits of VNS. We report the effects of VNS on seizure frequency and severity and how these changes are related to cognitive abilities, QOL, behaviour and mood in 15 children with medically refractory and for surgery not eligi

Background: Men with chronic renal failure evaluated for transplantation are often tested for prostate specific antigen (PSA) to detect prostate cancer. PSA occurs in several different molecular forms in serum: free PSA (fPSA) and complexed PSA (cPSA), the sum of which corresponds to total PSA (tPSA). In addition to tPSA, percent fPSA to tPSA (%fPSA) is widely used to enhance discrimination of ben

Surface exposed cysteines were genetically engineered in the structure of recombinant horseradish peroxidase (rHRP). Recombinant forms of HRP with either a His-tag or a Strep-tag at the C-terminus were produced, which additionally had cysteines at positions 57, 189 or 309 (C-terminus) of the polypeptide chain. An E coli expression system was exploited. The effect of these mutations on the direct e

In this thesis Word of Life (Slovo zivota) in the Czech Republic is studied from a sociological perspective with a special focus on the Swedish influence, especially the teachings of Ulf Ekman, on the Czech Word of Life-congregations. Another purpose is to examine if there also is space for domestic interpretations of the theology of the faith-movement and if there is any integration with Czech re

PURPOSE: It has been suggested that abdominal aortic aneurysms (AAA) develop as a result of an alteration in the systemic connective tissue metabolism. This might change wall mechanics and diameter, not only in the AAA but also in the rest of the vascular system. This hypothesis was tested by studying the mechanical properties of AAAs as well as the common carotid artery (CCA) in the same patient

Crosslinking of small heat-shock proteins (sHsps) by tissue transglutaminase (tTG) is enhanced by stress and under pathological conditions. We here used hexapeptide probes to determine the amine donor (K) and acceptor (Q) sites for tTG in Hsp20. Mass spectrometric peptide mass fingerprinting and peptide fragmentation established that Q(31) and the C-terminal K-162 are involved in inter- and intram

Chlordane was used as an insecticide for half a century until its withdrawal from the world market in 1997. Trans- and cis-chlordane (TC, CC) are racemic in the technical product, but undergo enantio selective degradation in soil to leave nonracemic residues. In most cases, the (+) enantiomer of TC and the (-) enantiomer of CC are depleted, leading to enantiomer fractions, EF = (+)/[(+) + (-)], th

This study of 36 rats with rat colon adenocarcinoma transplants was carried out to investigate the efficacy of a new method of whole blood immunoadsorption (WBIA) in removing biotinylated monoclonal antibodies (MAbs) directly from unseparated blood, in order to increase 'the tumor/normal-tissue uptake ratio', as compared with extracorporeal immunoadsorption (ECIA) of antibodies from plasma. Compar

The structurally related group II pyridoxal phosphate (PLP)dependent amino acid decarboxylases glutamic acid decarboxylase (GAD), aromatic L-amino acid decarboxylase (AADC), and histidine decarboxylase (HDC) are known autoantigens in endocrine disorders. We report, for the first time, the prevalence of serum autoantibody reactivity against cysteine sulfinic acid decarboxylase (CSAD), an enzyme tha