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Den upphandlande myndigheten ges en stor frihet vid upphandling och kan ställa krav på bl.a. leverantören och upphandlingsföremålet. Ett villkor vid kravställande är att kravet utformats på ett sätt som möjliggör en kontroll av kravet. Riktigheten av en leverantörs lämnande uppgifter ska kunna kontrolleras av den upphandlande myndigheten. Att ett krav ska vara möjligt att kontrollera följer av EU-The contracting authority is given a great freedom when negotiating a contract and may demand certain requirements, in relation to the supplier and the procurement object. A condition is that the requirement is formed in a way that allows verification of the requirement. The accuracy of the supplier's information must be possible to establish by the contracting authority. The fact that a requi

Lipoproteins, key mediators of lipid transport, facilitate the bidirectional transfer of lipids such as fatty acids, triglycerides, and cholesterol between soluble particles and cell membranes. High-density lipoproteins (HDL) primarily engage in reverse cholesterol transport, while low-density lipoproteins (LDL) predominantly deposit lipids, affecting cardiovascular health with a well-known role i

Background: Long-term survival after lung transplantation is significantly shorter compared with other solid organ transplantations. Chronic lung allograft dysfunction (CLAD), including bronchiolitis obliterans syndrome (BOS), remains the major barrier to survival. CLAD is diagnosed according to ISHLT's guidelines: a 20% drop in FEV1 using spirometry for CLAD grade 1. Given the difficulties of con

Purpose: Identifying biomarkers of radiotherapy (RT) response is important for optimizing the treatment of early breast cancer. In this study, we tested the interaction between endothelial cell (EC) expression of phospho-Tyr397-FAK (pY397-FAK) and adjuvant-RT on clinical outcomes after breast-conserving surgery (BCS) within a randomized study. Preclinical data suggest an enhanced effect of RT on l

AIMS/HYPOTHESIS: The aim of this work was to explore associations between type 1 diabetes progression from stages 1 or 2 to stage 3 and interacting ligand-receptor complexes of HLA class I (HLA-I) and KIR gene products.METHODS: Applying next-generation sequencing technology to genotype HLA-I genes (HLA-A, -B, -C) and KIR genes (KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5, KIR2DS1, KIR2DS2, KIR2DS3

Background: Branched-chain amino acids (BCAAs, isoleucine, leucine, and valine) are commonly applied to promote muscle protein synthesis. However, the effects of BCAAs on exercise-induced substrate metabolism, performance and post-exercise fatigue during endurance exercise remain unclear. Methods: In a double-blind cross-over design, eleven active males completed 1 h of constant load exercise (CLE

Aims Alternative splicing of Titin (TTN) I-band exons produce protein isoforms with variable size and elasticity, but the mechanisms whereby TTN splice factors regulate exon usage and thereby determining cardiomyocyte passive stiffness and diastolic function, is not well understood. Non-coding RNA transcripts from the antisense strand of protein-coding genes have been shown to regulate alternative

BACKGROUND: Bivalirudin was not superior to unfractionated heparin in patients with myocardial infarction (MI) treated with percutaneous coronary intervention and no planned use of GPI (glycoprotein IIb/IIIa inhibitors) in contemporary clinical practice of radial access and potent P2Y12-inhibitors in the VALIDATE-SWEDEHEART randomized clinical trial (Bivalirudin Versus Heparin in STEMI and NSTEMI

BACKGROUND: Patients benefit from antiplatelet therapy after coronary-artery bypass grafting (CABG) for an acute coronary syndrome. Whether the addition of ticagrelor to aspirin, as compared with aspirin alone, further reduces the risk of adverse cardiovascular outcomes is unclear.METHODS: In this open-label, registry-based, clinical trial conducted at 22 Nordic cardiothoracic surgery centers, we

Aims: To explore the association between soluble neuropilin-1 (sNRP-1) and depression in patients with newly diagnosed type 2 diabetes (T2D). Materials and Methods: Multicentre, cross-sectional study including adults with serologically confirmed newly diagnosed T2D. Included variables: sex, sNPR-1 (low sNRP-1 was defined as <226 ng/mL), psychometrically assessed depression and anxiety, antidepress

The importance of E-commerce in the grocery and food retailing is growing and an increasing number of home delivery solutions are being studied. Some observers predict that the consumers will use e-commerce and home delivery services more and more in the future. However, these developments are affected by a number of problems, many of which are not completely understood. This thesis particularly f

The effects of modern economic systems have put extensive pressure on the environment and society, both for this and future generations. Sustainable Development (SD) may offer the solution of pursuing development while ensuring the preservation of economic, environmental and social aspects for present and future generations. Throughout the centuries, universities and their faculty members have se

Sammanfattning Den här undersökningen handlar om hur svenska massmedier, i det här fallet dags- och kvällstidningar, framställer våldtäkt i sin nyhetsrapportering. Artiklarna är utvalda från två olika fall som blev omskrivna i svensk press. Utifrån bland annat filosofen Michel Foucaults diskursteori och med ett socialkonstruktivistiskt och genusviklat perspektiv analyseras en rad artiklar med hjä

Populärvetenskaplig sammanfattning: Conodonterna var en framgångsrik och diversifierad marin djurgrupp som levde från ungefär mellankambrium (~ 500 Ma) till slutet av trias (200 Ma). Från ett fåtal bevarade avtryck vet man att djuren var långsmala, endast några cm långa och hade fenor. Avtrycken är svårtolkade, men mycket tyder på att conodonterna var förhållandevis avancerade och kanske till och

Patentlagstiftningen är en lagstiftning med syfte att, i det allmännas intresse, främja den industriella utvecklingen. Lagstiftaren anser att patentmöjligheten är av särskild vikt för läkemedelsindustrin då den främjar läkemedelsutvecklingen, en utveckling som även är av intresse för allmänheten. I propositionerna till patentlagen menar lagstiftaren att patentmöjligheten främjar läkemedelsindustri

Varumärken har kommit att bli mycket värdefulla, ibland kan ett företags varumärke vara mer värt än dess fysiska tillgångar. Det finns idag ett antal regelverk som har betydelse för den svenska varumärkesrätten, bl.a. varumärkeslagen, varumärkesdirektivet och varumärkesförordningen. Dessa bestämmelser är i stort sett identiska vad gäller utformningen av vad som kan anses utgöra ett varumärke och d

As authorities, the universities are subject to the principle of access to official documents. Records generated during the research process are thus to be regarded as official documents, even though there are disputes over exactly when they are to be considered as such. Scientists are, to various degrees, dependent of access to earlier research data, which may have been collected during research