Gastrointestinal motility disorders are common in childhood and in this thesis we look at two of them, i.e. Hirschsprung´s Disease (HD) and gastroesophageal reflux disease (GERD) in five different studies. HD is a congenital disease characterized by an abscence of ganglion cells in myenteric and submucous ganglia, most commonly in the distal part of the large bowel. In Paper I, we have studied th

Background: Recently, some US cohorts have shown a moderate association between red and processed meat consumption and mortality supporting the results of previous studies among vegetarians. The aim of this study was to examine the association of red meat, processed meat, and poultry consumption with the risk of early death in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Background: Epidemiologic evidence of an association between fish intake and type 2 diabetes (T2D) is inconsistent and unresolved. Objective: The objective was to examine the association between total and type of fish intake and T2D in 8 European countries. Design: This was a case-cohort study, nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, with 3.99 m

Background: Age-related losses in bone mineral density (BMD), muscle strength, balance, and gait have been linked to an increased risk of falls, fractures and disability, but few prospective studies have compared the timing, rate and pattern of changes in each of these measures in middle-aged and older men and women. This is important so that targeted strategies can be developed to optimise specif

Mitochondrial dysfunction is implicated in neurodegenerative disorders, such as Alzheimer's disease (AD). Translocase of outer mitochondrial membrane 40 (TOMM40) may be influential in this regard by influencing mitochondrial neurotoxicity. Little is known about the influence of the TOMM40 gene on hippocampal (HC) volume and episodic memory (EM), particularly in healthy older adults. Thus, we sough

Background: Whey protein increases postprandial serum insulin levels. This has been associated with increased serum levels of leucine, isoleucine, valine, lysine, threonine and the incretin hormone glucose-dependent insulinotropic polypeptide (GIP). We have examined the effects of these putative mediators of whey's action on insulin secretion from isolated mouse Langerhans islets. Methods: Mouse p

Popular AbstractAvhandlingen tar sin empiriska utgångspunkt i en analys av hur historiskt betingade värden hanteras i samtida planering samt natur- och kulturmiljövård. Syftet är att därigenom förtydliga förutsättningarna för en hållbar landskapsutveckling avseende landskapets historiska värden. Analysen tar sin teoretiska utgångspunkt i tidsgeografi och kritisk realism. Perspektiven har använts fThis thesis is based on an analysis of how historically motivated values are treated in contemporary planning- and conservation practices. The aim is to discuss the premises of a sustainable landscape development regarding historical landscapes and heritage. The analysis takes its theoretical point of departure in time-geography and critical realism. These perspectives have been used to develop a

How to judge religions other than one's own when the means are lacking due to linguistic mobility? In the present thesis this question is mainly analysed in a Christian setting through a reading of the theologians Paul Knitter and Harold Netland. It is, however, claimed that the same question could be asked in other religious settings, also with regard to one's own tradition, and could be treated

The aim was to evaluate the effectiveness and feasibility of functional and nutritional assessments in geriatric rehabilitation in Copenhagen, Denmark, and in addition to study clinically identifiable risk factors for undernutrition, association between nutritional and ADL status, feasibility and effectiveness of nutritional intervention conducted by the nursing staff, and the nursing staffs attit

Five representative, and essentially dissimilar, novels by Ulla Isaksson are analysed in this book: the Christian novel Ytterst i havet (1950); the love story De två saliga ("The Blessed Ones" 1962); two novels dealing with feminine problems, Kvinnohuset (1952) and FödelseDagen (1988); and the historical novel Dit du icke vill (1956). The final chapter, on Dit du icke vill , also looks at the Chri

The European Spallation Source (ESS) is the European common effort in designing and building a next generation large-scale user facility for studies of the structure and dynamics of materials. The proposed schematic layout of the ESS facility is based on a linear driver (linac) directing the proton beam (5 MW of 2.5 GeV) of 2.8 ms long pulses with a 20 Hz on a tungsten target where neutrons are pr

ABSTRACT: BACKGROUND: It is known that physical activity during growth has a positive influence on bone mineral accrual, and is thus possibly one strategy to prevent osteoporosis. However, as bone geometry, independent of areal bone mineral density (aBMD), influences fracture risk, this study aimed to evaluate whether hip structure in pre-pubertal girls is also affected by a two-year exercise inte

A positive image of a city or region attracts people, investors and enterprises. High-quality environment and local sustainability initiatives can be used for creating a positive image. A growing number of regions and cities around the world have in recent years attempted to exploit this opportunity through sustainable development strategies and innovative environmental initiatives combined with g

Wireline communication is the Internet access technology with the largest number of subscribers worldwide. On physical-layer level, the traditional way to transmit signals at one end of a wire pair and to extract receive signals at the other end is to apply differential-mode signalling: transmit and receive signals correspond to voltage differences between the two wires. Differential-mode signalli

A constantly growing intercontinental trade and modernization of transport infrastructure transformed the traditional patterns of carriage of goods globally. The majority of manufactured goods nowadays are transported in by sea in containers; however, transportation by land precedes and follows the sea carriage. These developments have created the preconditions for the development of multimodal tr

Objective: To investigate the role of magnetic resonance imaging (MRI), assessment of bone mineral density (BMD) and antibodies to citrullinated proteins (anti-CCP) in predicting radiologic outcome in patients with early rheumatoid arthritis (RA). Patients: All patients were included in the BARFOT programme (baseline). The patients had rheumatoid arthritis of recent onset with mean disease duratio