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"Låt inte vår vilja ske, utan Jesu Kristi" : en undersökning av generalkonfessor Nicolaus Ragvaldis predikningar till systrarna i Vadstena kloster 1501-1506

My main purpose in this master thesis is to investigate what it meant to be a nun in Vadstena abbey in the beginning of the 16th-century according to the confessor general Nicolaus Ragvaldi. The main question of this thesis is: What should the ideal nun be like according to the sermons of the confessor general Nicolaus Ragvaldi performed in Vadstena abbey 1501 – 1506? While other legislative texts

Are dog noses too cool for the mammalian cold receptor TRPM8?

Med näsa för kyla: hudtemperatur och köldreception hos hundar Förmågan att känna temperatur är viktigt för att kunna identifiera behagliga samt undvika farliga temperaturer. Hittills har forskningen kring hur däggdjur uppfattar, för oss, smärtsamt kalla temperaturer lett till fler frågor än svar. En av orsakerna till detta är sannolikt att försöksdjuren som normalt används inom temperaturforskni

The impact of horizontal projections on external fire spread - A numerical comparative study

Balkongplattor som alternativ till bröstning i byggnadsfasaden Tidigare forskning har visat att brandspridning i bostadshus ofta sker vertikalt via fönster i byggnadsfasaden. Samtidigt visar sig nivån på brandskyddet mot detta skilja sig åt mellan olika länders byggnadsregler. Att det finns oenighet i frågan antyder att ytterligare forskning behövs inom ämnet. I avsnitt 5:553 av de svenska bygg

Hur används miljöbalkens rimlighetsavvägning vid miljötillståndsprövning?

Vad är rimligt att betala för att minska belastningen på miljön? Den frågan ska miljöprövningsmyndigheter som godkänner etableringar miljöfarliga verksamheter ta ställning till enligt den så kallade rimlighetsavvägningen som regleras i den svenska miljölagstiftningen. Syftet med lagen är att kostnaderna för att minska miljöpåverkan inte ska överstiga nyttan för samhället. Vad som är rimliga kostna

”Kraven kommer från tusen olika håll” En kvalitativ studie om psykisk ohälsa bland unga ur kuratorers perspektiv

Current research and media tend to write about how mental illness among young people increases. Therefore it is easy to get the impression that there are many young people who suffer from mental illness nowadays. Counselors at schools and at youth clinics are in daily contact with young people who feel bad in some way. The main aim of this bachelor thesis was to present and analyze mental illness

Värdering i tvistiga klyvningar

Vid ett klyvningsförfarande är tanken att all ingående mark ska värderas i någon omfattning för att sedan fördelas mellan delägarna enligt deras respektive andel. Det har observerats exempel på värderingar som inte alltid gjorts enligt lag med en graderingsvärdering, det vill säga en värdering med mark i obebyggt skick och skog av normal karaktär, utan att denna istället gjorts efter en likvidvärdDuring a property partition the idea is that all land should be appraised to some extent, so that it can later be distributed among the co-owners according to their respective share. In a few examples of appraisals used by the National Land Survey there has been signs of irregularities in the application of grading appraisals. In some of these cases land has been appraised including buildings and

3D Delineation: A modernisation of drawing methodology for field archaeology

A recent trend concerning archaeological research has focused on producing a real-time methodology for 3D digital models as archaeological documentation within the excavation setting. While such methodologies have now firmly been established, what remains is to explore how 3D models can be integrated more fully alongside other forms of archaeological documentation. This thesis explored one avenue

Nonneutralizing antibodies in Nordic persons with moderate hemophilia A and B (the MoHem study)

Background: The impact of nonneutralizing antibodies (NNAs) in moderate hemophilia is elusive. Objectives: To explore the presence of NNAs in Nordic persons with moderate hemophilia A (MHA) and B (MHB) in relation to treatment modality, clinical outcome, history of inhibitor, and the corresponding factor VIII (FVIII)/factor IX (FIX) gene mutation. Methods: A cross-sectional multicenter study cover

Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities 1,2 . This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity 3–6 . Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to re

Genetic associations of neuropathic pain and sensory profile in a deeply phenotyped neuropathy cohort

We aimed to investigate the genetic associations of neuropathic pain in a deeply phenotyped cohort. Participants with neuropathic pain were cases and compared with those exposed to injury or disease but without neuropathic pain as control subjects. Diabetic polyneuropathy was the most common aetiology of neuropathic pain. A standardised quantitative sensory testing protocol was used to categorize

The Effectiveness of Preventive Maintenance in Railways

Railway maintenance is crucial for ensuring system availability, punctuality, safety, and comfort. Though studies have shown that in reality, maintenance is 'imperfect'-inspections do not reveal all defects and repairs do not return components to as good as new and may even leave them in a worse state, railway maintenance planning is still based on periodic block-type and age-based maintenance pol

Incidence of constrained condylar and hinged knee implants and mid-to long-term survivorship : a register-based study from the Nordic Arthroplasty Register Association (NARA)

Background and purpose — In complex primary total knee arthroplasty (TKA), constrained condylar knee (CCK) or rotating hinge knee (RHK) designs may be required to provide stability or address bony deficiencies. We analyzed trends in incidence of these designs in primary TKA and evaluated the mid-to long-term survivorship of CCK and RHK in 4 Nordic countries. Methods — From 2000 to 2017, 5,134 CCK

Modulation of the sodium-chloride cotransporter by insulin in auditory cells : A potential link to diabetes-related hearing complications

Aim: While diabetes mellitus (types 1 and 2) is known to negatively impact vestibular and auditory function, the precise mechanisms underlying this effect are not fully understood. Building on our previous findings, which demonstrated the presence of insulin signaling components within the human saccule and identified the sodium transporter ENaC as a target for insulin signaling in HEI-OC1 auditor

Complement factors as biomarkers in ANCA-associated vasculitis in remission

Background Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of rare, autoimmune diseases causing inflammation in the vessel wall. Many organs can be affected, and kidney involvement is a common and serious manifestation. Complement activation is important in disease development and has also been detected in patients in remission. The reason for increased complemen

Polygenic scores and symptom severity change after internet-delivered cognitive behaviour therapy for depression and anxiety

Depressive and anxiety disorders are leading causes of disability globally. Therapist-guided, Internet-delivered cognitive behaviour therapy (ICBT) is an established treatment for depression and anxiety, but a considerable proportion of treated patients do not achieve sufficient improvement. Predicting symptom changes based solely on clinical variables is challenging, and genetic data could offer

Adding salt to foods and risk of metabolic dysfunction-associated steatotic liver disease and other chronic liver diseases

PURPOSE: Adding salt to foods, a novel indicator for studying habitual sodium intake, has been positively associated with multiple diseases and mortality. However, little is known about its association with liver-related disorders. This study aimed to investigate the associations of adding salt to foods with risks of metabolic dysfunction-associated steatotic liver disease (MASLD), cirrhosis, and

Acinetobacter baumannii Clinical Isolates Resist Complement-Mediated Lysis by Inhibiting the Complement Cascade and Improperly Depositing MAC

Introduction: Acinetobacter baumannii is a gram-negative opportunistic bacterium that causes life-threatening infections in immunocompromised hosts. The complement system is a critical mechanism of innate immunity that protects the human body from bacterial infections. Complement activation leads to the deposition of the membrane attack complex (MAC), which can directly lyse gramnegative bacteria.