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In the wake of densification and urbanisation, crowding has become an increasingly important issue for social sustainability in cities. This also affects urban design and the ways public spaces stimulate different kinds of crowding and clustering. There are, of course, several factors which affect pedestrian clustering and declustering in public spaces, factors that determine how and why people ac

Obesity is the main risk factor behind insulin resistance and type 2 diabetes. Still, the mechanism behind adipocyte dysfunction is not yet resolved. Recently, we reported that rapid actin remodeling correlates with adipose cell size changes after short-term overfeeding. Therefore, we hypothesized that the actin-driven myocardin-related transcription factor (MRTF-A) contributes to impaired mature

Paradoxes of Media and Information Literacy: The Crisis of Information contributes to ongoing conversations about control of knowledge and different ways of knowing. It does so by analysing how media and information literacy (MIL) is proposed as a solution for addressing society’s crisis of information. Questioning why MIL is commonly believed to wield such power, the book throws into sharp relief

Background: In 2006 and 2007 we performed double lung transplantation with marginal donor lungs assessed and reconditioned by Ex Vivo Lung Perfusion (EVLP), using a technique developed by Professor Stig Steen. Here we present a 10-year follow-up comparing the outcomes of lung transplantations performed at our clinic using EVLP lungs vs. conventional lungs. Method: Between 2006 and 2007, 21 patient

Background: Coronary artery disease (CAD) is a leading cause of death worldwide and increasing cost for society. Genome wide association studies (GWAS) have identified common variants associated with CAD. Combining single nucleotide polymorphisms (SNPs) into a genetic risk score (GRS) can estimate an individual's genetic burden. Objectives: To investigate whether GRS for CAD can predict hospitaliz

Aims/hypothesis: Given the importance of glucagon in the development of type 2 diabetes and as a potential therapeutic agent, the aim of this study was to characterise glucagon kinetics in mice and its regulation by the nutritional state. Methods: Anaesthetised C57BL/6 mice fed normal or high-fat diets, or fasted, were injected intravenously with glucagon (0.1, 0.3, 1.0, 10.0 or 20 μg/kg); blood s

The purpose of this study was to compare the status of psychosocial factors and glycemic control in insulin-naïve and insulin-experienced people with type 2 diabetes (T2D). In this observational study on people with T2D, demographic, self-care behavior, resources, and affective variables as well as health-related quality of life were assessed and compared in insulin-naïve and insulin-experienced c

Cadmium and lead have been classified as carcinogens by the International Agency for Research on Cancer. However, their associations with breast cancer risk are unknown despite their persistence in the environment and ubiquitous human exposure. We examined associations of circulating levels of cadmium and lead with breast cancer risk in three case–control studies nested within the Cancer Preventio

Pyrimethanil (PYM) is a fungicide used pre- and post-harvest on many crops. It has a low acute toxicity but is of toxicological concern because of its antiandrogenic properties. The aim of the current work was to investigate some metabolism and estimate elimination kinetics of PYM in humans after experimental oral and dermal exposure. A liquid chromatography triple quadrupole mass spectrometry (LC

NOx pollution from Diesel engines causes over 10 000 premature deaths annually and the trend is increasing. In order to decrease this growing global problem, exhaust after-treatment systems for Diesel engines have to be improved. The most common SCR systems in the market place inject an aqueous Urea solution, DEF that evaporates prior the catalytic surface of the SCR-catalyst. Due to a catalytic r

Loss and fragmentation of semi-natural grasslands have had negative consequences for grassland biodiversity, such as butterflies. Urban parks and other urban green spaces have so far largely been overlooked as suitable butterfly habitats, although they could potentially sustain diverse butterfly populations over time. We analysed the temporal change in butterfly species assemblages in urban green

Background: Revascularization is a treatment option for patients with intermittent claudication. However, there is a lack of evidence to support its long-term benefits and cost-effectiveness. The aim of this study was to compare the cost-effectiveness of revascularization and best medical therapy (BMT) with that of BMT alone. Methods: Data were used from the IRONIC (Invasive Revascularization Or N