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Impact of mono- or multitherapy on ocular surface health and quality of life after 5 years of follow-up in the Glaucoma Intensive Treatment Study (GITS)

Aim: To evaluate the impact of initial mono- versus multitherapy on the ocular surface and related quality of life after 5 years follow-up in the Glaucoma Intensive Treatment Study (GITS). Method: The study included patients with primary open-angle glaucoma and pseudoexfoliation glaucoma who completed 5-year follow-up in GITS. Assessment of ocular surface disease (OSD) symptoms was done using a Sw

Elexacaftor–tezacaftor–ivacaftor enhances first-phase insulin secretion and improves glucose control in cystic fibrosis

Objective: Cystic fibrosis (CF) is a congenital condition caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. CF-related diabetes (CFRD) is a common comorbidity among people with CF (pwCF) and is associated with increased morbidity. Previous in vitro studies have suggested that CFTR dysfunction is involved in the pathogenesis of CFRD. This prospective study aimed to eval

Defining consumer value in C2C return processes: Toward more sustainable and cost-efficient E-commerce. An explorative qualitative study on consumer expectations and attitudes on C2C returns in e-commerce

This thesis explores the end-consumers’ perspective on C2C returns within e-commerce. It investigates the consumer's attitudes towards and expectations of the service by investigating potential motivational incitements and perceived hinders when potentially participating in the process. A literature review on current research on returns management and C2C services was conducted, followed by fo

Prediktion av massflöden vid förbehandling av substratblandningar före samrötning

Biogas är ett förnybart bränsle som tillverkas genom att organiskt avfall bryts ner utan syre. På St1 Biokrafts anläggning i Södertörn används avfall som matrester, gödsel och slakteriavfall för att producera biogas och biogödsel. Innan det organiska materialet förvandlas till biogas genom rötning kan avfallet förbehandlas för att påskynda processen och för att producera en rötrest som kan använda

Autoimmune Thyroid Disease in a Cohort of Children With Increased Genetic Susceptibility to Type 1 Diabetes : The Environmental Determinants of Diabetes in the Young Study

Objective: Clinical autoimmune thyroid disease (AITD), presenting as either hypo- or hyperthyroidism, can occur at any age. Autoantibodies against thyroid peroxidase or thyroglobulin precede the onset of clinical AITD. We aimed to assess factors associated with AITD in children and determine if risk factors for AITD differ among the subset who have developed thyroid autoantibodies. Design: Prospec

Oxygen isotope-based evidence for stepwise climate cooling aligns with the tripartite division of the Ordovician

The Ordovician Period includes two major macroevolutionary events: the Great Ordovician Biodiversification Event (GOBE) and the Late Ordovician Mass Extinction (LOME), alongside a fundamental climate transition from a greenhouse to an icehouse state. Although both biological events occurred during relatively short-term global cooling conditions, their starkly contrasting biotic responses remain po

ClusterVAP : study protocol for multicentre proteomic endotyping of ventilator-associated pneumonia

INTRODUCTION: Ventilator-associated pneumonia (VAP) is the most frequent healthcare-associated infection in intensive care units and is associated with high morbidity and mortality. Current diagnostic criteria lack specificity, leading to misclassification and unnecessary antibiotic use. Identifying patient subgroups with a common pathophysiological basis (pneumoclusters) may distinguish true VAP

Performance and safety of a novel, cable-free, patch-based, and AI-enhanced ECG monitoring system : A comparative study

Aims ECG monitoring is often required during critical phases of illness. To evaluate the role of modern technology and advanced analytical algorithms artificial intelligence compared with standard-of care, we undertook a prospective, head-to-head comparison of a novel, cable-free, patch-based, and AI-enhanced electrocardiography system (CardioSenseSystem) with standard of care (SOC) ECG monitoring

Rätten till integritet vid bekämpning av penningtvätt - En undersökning av motstridiga krav mellan AML-regleringen och dataskyddsförordningen

Bekämpningen av penningtvätt utgör ett centralt samhällsintresse inom Europeiska unionen och har gett upphov till ett omfattande regelverk som ställer långtgående krav på att verksamhetsutövare behandlar och lagrar personuppgifter. Samtidigt har skyddet för den personliga integriteten stärkts genom EU:s allmänna dataskyddsförordning (GDPR). Regelverken är inte direkt motstridiga, men förutsätter eThe fight against money laundering constitutes a central public interest within the European Union and has resulted in an extensive regulatory framework imposing far-reaching obligations on obliged entities to process and retain personal data. At the same time, the protection of personal privacy has been strengthened through the EU General Data Protection Regulation (GDPR). Although these regulato

Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes

Heart failure (HF) is a major contributor to global morbidity and mortality. While distinct clinical subtypes, defined by etiology and left ventricular ejection fraction, are well recognized, their genetic determinants remain inadequately understood. In this study, we report a genome-wide association study of HF and its subtypes in a sample of 1.9 million individuals. A total of 153,174 individual

Reconstruction of electrical resistivity tomography (ERT) data using different base measurements

Electrical resistivity tomography (ERT) is a widely used technique for imaging subsurface resistivity distributions, but conventional data acquisition strategies face trade-offs between resolution, efficiency, and data quality. Comprehensive datasets that maximize subsurface information are impractical to measure directly, motivating the development of ERT data reconstruction approaches that can g

Cardiovascular-kidney-metabolic syndrome : prevalence, risks, disease trajectories, and early-stage management

Cardiovascular-kidney-metabolic (CKM) syndrome affects approximately 90% of US adults, arising from the convergence of metabolic dysfunction, chronic kidney disease (CKD), and cardiovascular disease (CVD). These conditions create self-reinforcing cycles of multiorgan damage, substantially increasing mortality risk. The American Heart Association’s 2023 staging framework stratifies CKM from stage 0

Hundvänlig : Utmaningar, metoder och affärsmöjligheter för besöksnäringen

Denna rapport analyserar framväxten av hundvänlig turism i Sverige och belyser dess betydelse för besöksnäringens utveckling. Studien visar att hunden i allt högre grad betraktas som en familjemedlem, vilket påverkar resenärers beteenden, val av destination och konsumtionsmönster. Hundägare utgör en reseaktiv och kommersiellt attraktiv målgrupp som främst reser inom Sverige och efterfrågar naturba