Filetype
Although biologics have revolutionized psoriasis treatment, they pose a significant burden on the healthcare budget. With the wide range of biologics available and the increasing number of biosimilars, insights into the real-world cost per responder (CPR) are required. Therefore, this study aims to evaluate the real-world CPR of adalimumab, ustekinumab, IL17-and IL23-inhibitors, incorporating both
Bus Rapid Transit (BRT) has predominantly been implemented in major urban areas worldwide, but interest is growing in its application within small and medium-sized cities. In these contexts, enhanced bus-based public transport is often essential for promoting more sustainable transport systems. However, limited research has explored how BRT can be adapted to smaller cities, particularly in Europe,
Insulin resistance (IR) contributes to atherogenic dyslipidemia and elevated ASCVD risk. Apolipoprotein A1 (ApoA1)-associated lipoproteins have diverse anti-atherogenic functions, but it is unclear whether IR drives adverse changes in their proteomic composition. We hypothesized that IR is associated with an atherogenic ApoA1 proteome and that insulin-sensitizing interventions would improve its co
Purpose: Direct laryngoscopy (DL) is the standard technique for endotracheal intubation. Video-assisted laryngoscopy (VL) has emerged as an alternative, particularly for difficult airway management. Nevertheless, DL and VL have not been systematically compared for simulation-based endotracheal intubation by inexperienced operators. Method: A prospective, randomized cross-over study was carried out
Aims: This study compares the associations of Life's Simple 7 (LS7) and Life's Essential 8 (LE8) with all-cause and cardiovascular mortality in cardiovascular-kidney-metabolic (CKM) syndrome populations. Methods: This cohort study analyzed 11,487 participants aged ≥20 years with CKM syndrome from NHANES 2005–2018. Participants were categorized into non-advanced (stages 0–2) and advanced (stages 3–
Uppsatsen handlar om självkostnadsprincipen i AB 04 och de problem som ofta uppstår vid ersättning på löpande räkning. Tvister mellan entreprenör och beställare handlar ofta om vilka kostnader entreprenören kan ersättas för och hur dessa ska styrkas. I AB 04 uppstår här en problematik eftersom det sak-nas en tydlig definition av vad som avses med en ”kostnad”. För entreprenö-ren innebär detta osäk
Denna uppsats behandlar det svenska granskningssystemet för utländska direktinvesteringar, etablerat genom lag (2023:560) om granskning av utländska direktinvesteringar. Uppsatsen fokuserar på förhållandet mellan en långtgående anmälningsplikt och det begränsade antal ärenden där granskningsmyndigheten inleder en materiell granskning eller vidtar ingripande åtgärder. Sedan lagens ikraftträdande h
Uppsatsen behandlar brottet förolämpning mot tjänsteman och hur bestäm-melsen tillämpas i praktiken när målsäganden är polis. Syftet är att analysera vilka omständigheter som tillmäts betydelse vid bedömningen av straffbarhet samt var gränsen dras mellan straffbara och icke straffbara uttalanden. Arbetet är genomfört med rättsdogmatisk metod och bygger på lagtext, för-arbeten, rättspraxis och releThis thesis examines the offence of insult against a public official and how the provision is applied in practice when the injured party is a police officer. The purpose is to analyse which factors are given weight in the assessment of criminal liability and where the boundary is drawn between punishable and non-punishable statements. The study is conducted using a legal dogmatic method and is bas
Timely diagnosis of type 1 diabetes (T1D), especially in high-risk populations, is crucial for preventing serious health complications. T1D is a chronic progressive autoimmune disease that has presymptomatic stages that can be identified through the detection of islet autoantibodies. Given that T1D is associated with other autoimmune diseases, having either those diseases or a family history of th
Microglia exhibit targeted responses to different stimuli, including lipids, which can differ depending on the environmental conditions they encounter. These responses involve inflammatory mediators and are crucial for maintaining brain homeostasis. This study investigated whether inflammatory, metabolic, and phagocytic responses of microglia to the saturated fatty acid palmitate depend on extrace
Bullying is increasingly understood as a group-based phenomenon in which bystanders play a critical role, yet little is known about how witnessing bullying affects bystanders’ self-esteem and academic motivation. The aim of this study was to explore adolescents’ perspectives on how witnessing bullying in school may be linked to their self-esteem and academic motivation. This qualitative study expl
The downscaling of environmental responsibilities poses new challenges for regional governments, necessitating an evolution in their roles to manage environmental policy alongside traditional local development duties. This paper draws on the concept of the entrepreneurial state and on the idea of the ‘entrepreneurial region’ to explore how local and regional governments implement bioeconomy polici
Purpose: Surgical repair of parastomal hernias (PH) is challenging, mainly due to high recurrence rates. The Local Parastomal repair (LoPa) is a novel technique utilizing a retromuscular synthetic mesh with an outward-facing collar. This study describes the LoPa technique and evaluates its outcomes. Methods: This single-centre study retrospectively reviewed 39 consecutive patients who underwent Lo
Introduction: Child abuse is a global public health problem. It poses a threat to both physical and psychosocial well-being, resulting in serious consequences for the child, the family, and society. Radiographers are in a unique position to identify children at risk. In clinical practice, they may observe unusual interactions between children and their caregivers during radiographic procedures or
