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Genome wide association studies (GWAS) identify susceptibility loci for complex traits, but do not identify particular genes of interest. Integration of functional and network information may help in overcoming this limitation and identifying new susceptibility loci. Using GWAS and comorbidity data, we present a network-based approach to predict candidate genes for lipid and lipoprotein traits. We

Background-eQTL analyses are important to improve the understanding of genetic association results. We performed a genome-wide association and global gene expression study to identify functionally relevant variants affecting the risk of coronary artery disease (CAD). Methods and Results-In a genome-wide association analysis of 2078 CAD cases and 2953 control subjects, we identified 950 single-nucl

Type 1 diabetes mellitus (T1DM) is an autoimmune disorder directed against the β cells of the pancreatic islets. The genetic risk of the disease is linked to HLA-DQ risk alleles and unknown environmental triggers. In most countries, only 10-15% of children or young adults newly diagnosed with T1DM have a first-degree relative with the disease. Autoantibodies against insulin, GAD65, IA-2 or the ZnT

BACKGROUND: CYP2J2 is responsible for the production of 5,6 8,9 11,12 and 14,15-epoxyeicosatrienoic acids, vasodilator and anti-inflammatory substances. It is abundantly expressed in human heart and also present in kidney and vasculature. Carriers of a common polymorphism, the CYP2J2-50G>T, rs890293, have reduced expression of CYP2J2 mRNA level in the heart putatively through the interference with

Objective Zinc transporter 8 autoantibodies (ZnT8A) have been poorly studied in non-Caucasian individuals. We aimed to investigate the prevalence of ZnT8 autoantibodies in patients with T1D and their first degree relatives (FDR) from a multiethnic population, as well as its relation with the insulin (INS) or the protein tyrosine phosphatase non-receptor 22 (PTPN22) gene polymorphisms. Subjects and

Recent discussions about a stolen cultural heritage have resulted in several repatriation claims from indigenous people. These claims are often considered a way to disengage from a coloni-al past. There are numerous conventions and ethical guidelines about repatriation to consider; nevertheless repatriation cases are being handled in different ways across the globe. In 2004 the Jewish congregation

Uppsatsens titel: Vilka faktorer påverkar möjligheterna att använda Yield Management? - En komparativ fallstudie mellan den svenska flyg- och fotbollsbranschen. Seminariedatum: 2012-05-29 Ämne/kurs: FEKN90 - Företagsekonomi: Examensarbete på civilekonomprogrammet Författare: Henrik Agardh & Jonathan Lindwert Handledare: Niklas Hallberg Nyckelord: Dynamiska prissättningsstrategier, Marknadsacce

The aim of this paper was to understand the central place aspects of Mahasthangarh and Uppåkra according to analyze the definition of central place theory based on political, economical and religious aspects in archaeological perspective. Mahasthangarh is located in the Northern part of Bangladesh identified as Early Historic (c. 500 BC to 550 AD) to Medieval Period (c. 550 AD to 1200 AD) site in

The purpose of this paper is to deliver a clearer picture regarding the possible effects of the in-store TV screens on consumers’ impulse purchase decision and how factors such as the gender and generation can influence the consumers’ behavior towards this digital signage. Therefore this objective academic paper will contribute to bring discernment and relevant material for future studies through

"There's a difference between reading about things and getting into the practical" - teacher students' knowledge and expectations of the mandatory report The Social Services' investigation of child maltreatment and neglect is dependent on information from school teachers. The mandatory report requires all school personnel to report incidents involving children who may need S

Populärvetenskaplig sammanfattning: På stranden i Haväng på Österlen finns ett område precis norr om Verkeåns mynning där sanden är uppseendeväckande mörk, nästan svart på sina ställen. Söder om mynningen är sanden lika ljus som på vilken vanlig strand som helst. Det som ger denna färgskillnad är att sanden på den norra sidan av åns mynning delvis består av tunga mineral, varav några är mörka. DärAt the beach in Haväng, an area with remarkably dark sand is located just north of the outlet of Verkeån. The sand is almost black in some places. South of the outlet the sand is as light as normal beach sand. What gives this colour difference is that the sand north of Verkeån contains some heavy minerals, some of which are dark. The placer deposit contains among other minerals zircon, apatite, ru

This paper is about how symphony orchestras relate to marketing principles such as the Four Ps and other similar theories adapted to better suit the need of the Arts. Arts institutions like symphony orchestras are traditionally not-for-profit organizations, but with state subsidies not growing in size with the growth of costs for symphony orchestras, they must find other ways to fund their organiz

Populärvetenskaplig sammanfattning Fenologi innebär studier av naturligt återkommande händelser som till exempel bladsprickning, knoppbristning och vissningen av blad. Det är viktigt att förstå hur klimatförändringen påverkar tidpunkten då dessa händelser sker eftersom det i sin tur påverkar kol-, närings- och den hydrologiska cykeln. Fältobservationer har varit den mest använda metoden för att saPhenology is the study of the timing of natural events such as leaf-out, bud burst and senescence relative to climate change. It is important to understand how the climate change will affect the timing of these events as it in turn affects the carbon-, nutrient- and the hydrological cycles. Field observations is the most common way to gather phenology data but the result is dependent on the skill

Ett första steg i arbetet att uppskatta kolflödet mellan landbaserade ekosystem och atmosfären är att så precist som möjligt analysera kvantiteten ovanjordisk biomassa. LiDAR teknologi har i detta avseende visat sig vara ett värdefullt verktyg. Det överlöpande målet med denna studie är att utveckla en förenklad metod, baserad på fjärranalys, för att uppskatta ovanjordisk biomassa för individuella As a first step in the assessment of carbon flux between the terrestrial environment and the atmosphere it is important to accurately quantify the carbon stock of forest ecosystems. LiDAR technology, in this respect, has proved to be a valuable tool, able to provide accurate estimates of aboveground biomass (AGB). The overall goal of this study was to develop a simplified method for assessing AGB