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Immune responses against modified self-antigens generated by hypercholesterolemia play an important role in atherosclerosis identifying the immune system as a possible novel target for prevention and treatment of cardiovascular disease. It has recently been shown that these immune responses can be modulated by subcutaneous injection of adjuvant. In the present study we immunized 25-week old ApoBec

Endemic diseases are caused by environmental and genetic factors. While in this special issue several chapters deal with environmental factors, including infections, the present focus is on genetic causes of disease clustering due to inbreeding and recessive disease mechanisms. Consanguinity is implying sharing of genetic heritage because of marriage between close relatives originating from a comm

Population-based registries may provide data complementary to that from basic science and clinical intervention studies, all of which essential for establishing recommendations for the management of patients in the real world. The same quality criteria apply for the evidence-based label, and both high representation and good data quality are crucial in registry studies. Registries with high covera

BACKGROUND: A major problem in clinical lung transplantation is the shortage of donor lungs. Only about 20% of donor lungs are accepted for transplantation. A method to evaluate and recondition lungs ex vivo has been tested on donor lungs that have been rejected for transplantation. METHODS: The donor lungs were reconditioned ex vivo in an extracorporeal membrane oxygenation (ECMO) circuit with ST

The release of organic compounds during the drying of biomass is a potential environmental problem, it may contribute to air pollution or eutrophication. In many countries there are legal restrictions on the amounts of terpenes that may be released into the atmosphere. When considering bioenergy in future energy systems, it is important that information on the environmental effects is available. T

The pathophysiologic mechanisms in type 1 diabetes (T1DM) involve loss of islet β-cell secretory function caused by selective killing of these cells primarily by aggressive autoimmune responses involving both cellular and humoral immune pathways. Inflammatory cells heavily infiltrate pancreatic islets leading to insulitis where CD8+ T lymphocytes are thought to be responsible for selective and spec

According to the traditional view, the relation between morphology and syntax is the following: while morphology builds up word forms—typically by combining roots with other roots and with affixes, but also by applying other operations to them, syntax takes fully inflected words as input and combines them into phrases and sentences. The division of labour between morphology and syntax is thus perf

In this thesis, two questions are answered: What is burnout?, and What causes burnout? Essentialist conceptions of burnout are criticized and burnout is regarded as a syndrome in the sense of a practice concept, not possible to delineate exactly. Practice concepts are compared to social constructions. From the syndrome idea, the Maslach Burnout Inventory (MBI), is chosen as an operationalization o

Improving electrical efficiency has been proposed as the most convenient means of reducing, e.g. CO₂ emission from power plants. Increasing fuel utilization through combined heat and power generation is another useful measure for emission reduction. Trigeneration technology for the production of heat, power and cooling is an interesting alternative for further improvement of fuel utiliz

Josef Bexell as soul-carer Josef Bexell (1815–1897), Lutheran rector of Långaryd in the diocese of Växjö, was widely known as a soul-carer, both in public and in private. His sermons were not only heard in Church, but circulated and read in private, and questions from his private soul-care were answered in public preaching. The private soul-care was performed both in private encounters and in lett

Cocaine- and amphetamine-regulated transcript (CART) is a regulatory peptide expressed in the nervous system and in endocrine cells, e.g. in pancreatic islets. CART deficient mice exhibit islet dysfunction, impaired insulin secretion and increased body weight. A mutation in the CART gene in humans is associated with reduced metabolic rate, obesity and diabetes. Furthermore, CART is upregulated in

Recent epidemiological as well as in vivo and in vitro studies collectively suggest that the metalloestrogen cadmium (Cd) could be a potential risk factor for hormone-related cancers in particularly breast cancer. Assessment of the association between Cd exposure and levels of endogenous sex hormones is of pivotal importance, as increased levels of such have been associated with a higher risk of b

BackgroundStandard treatment of adult Burkitt lymphoma is not defined due to the lack of randomised trials. In this situation, population-based data may represent a useful contribution in order to identify an optimal treatment strategy.Patients and methodsThe aims of this study were to investigate the outcome for adult HIV-negative BL with different chemotherapy regimens, and to assess possible im