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In response to fasting or hyperglycemia, the pancreatic β-cell alters its output of secreted insulin; however the pathways governing this adaptive response are not entirely established. While the precise role of microRNAs (miRNAs) is also unclear, a recurring theme emphasizes their function in cellular stress responses. We recently showed that miR-184, an abundant miRNA in the β-cell, regulates co
Macrophytes in shallow lakes have the potential to alter fish-zooplankton interactions considerably. How far predation effects by newly hatched fish (0+ fish) on zooplankton are influenced by different types of aquatic vegetation, and how effects change during the first weeks of fish ontogeny remains, however, less clear. In order to address these issues, we examined the predation effects of 0+ fi
An online survey in the form of a questionnaire was conducted to obtain the opinion of computer users with tetraplegia on their current computer interfaces and to assess desirable applications for future independent control using assistive devices. The survey included questions related to information about the respondents' injury/disease, everyday activities and social life, electronic devices and
Lack or dysfunction of insulin producing β cells results in the development of type 1 and type 2 diabetes mellitus, respectively. Insulin secretion is controlled by metabolic stimuli (glucose, fatty acids), but also by monoamine neurotransmitters, like dopamine, serotonin, and norepinephrine. Intracellular monoamine levels are controlled by monoamine oxidases (Mao) A and B. Here we show that MaoA
Thylakoids are chlorophyll-containing membranes in chloroplasts that have been isolated from green leaves. It has been previously shown that thylakoids supplemented with a high-fat meal can affect cholecystokinin (CCK), ghrelin, insulin and blood lipids in humans, and can act to suppress food intake and prevent body weight gain in rodents. This study investigates the addition of thylakoids to a hi
‘The model of crisis’ is a culturally shared and widespread idea of human reactions to a number of misfortunes, such as accidents, diagnosis of disease, divorces, becoming a parent of a disabled child, etc. The crisis model conveys the idea of coming to terms with unwanted experiences while advancing through different “phases”, for example phases of “denial”, “processing”, and “acceptance”. The
Currently, there is increasing competition for waste as feedstock for the growing number of biogas plants. This has led to fluctuation in feedstock supply and biogas plants being operated below maximum capacity. The feasibility of supplementing a protein/lipid-rich industrial waste (pig manure, slaughterhouse waste, food processing and poultry waste) mesophilic anaerobic digester with carbohydrate
Haemophilia A (HA) is caused by defective synthesis of coagulation factor VIII(FVIII), which has serious effects on haemostasis; joints being the most common site of bleeding. The development of FVIII replacements has improved the situation for patients with haemophilia such that chronic arthropathy can be prevented, and life expectancy and the quality of life have increased. However, approximatel
Background. For Diffuse large B-cell lymphoma (DLBCL), the International Prognostic Index is the major tool for prognostication and considers an age above 60 years as a risk factor. However, there are several indications that increasing age is associated with more biological complexity, resulting in differences in DLBCL biology depending on age. Methods. We conducted a registry-based retrospective
Popular Abstract in Undetermined Populärvetenskaplig sammanfattning på svenska Nästäppa, som betyder svårigheter att andas med näsan är ett vanligt symtom i befolkningen, och en vanlig orsak till att patienter söker vård. Kronisk nästäppa är ett frekvent symtom (ca 40 % av vuxna) som ofta medför mun-andning med torra slemhinnor i munhåla och svalg samt snarkning till följd. Nässkiljeväggen, septSubjective nasal obstruction is a common chronic complaint caused by mucosal disease, skeletal abnormality or a combination of both. The challenge is to determine the main cause and to decide whether the intervention should be medical or surgical. Diagnosis is done by a combination of rhinoscopy, subjective and objective assessments of nasal obstruction. Rhinomanometry measures the nasal airway re
During the past 15 years lung transplantation has been established as a therapeutic option for patients with end-stage pulmonary disease. The results have improved over time and some transplantation centers now show 1-year survival rates above 80%. The number of donors has remained relatively constant during later years but the demand is increasing resulting in longer waiting times and an increasi
AIM: To study infantile colic in terms of occurrence, risk factors in pregnancy, distress patterns, caregiving practices, and outcome. STUDY DESIGNS: Paper I: Population study, 376 mothers and newborn infants, diaries or telephone interviews. Paper II: 116 colic and 119 control cases, telephone interviews, and diaries. Papers III-IV: Population study, 1099 mother-infant dyads, pregnancy inquiries
The subject of this thesis is the clinical use of transesophageal echocardiography (TEE) in patients with stroke or atrial fibrillation. Subjects were examined with echocardiography and sonography of the carotid artery. A control group of randomly selected volunteers without cerebrovascular disease was compared to patients with ischemic stroke. Cardiac pathology was classified as minor potential e
All elbow fractures between 1969 – 1979 (n=2965) registered at the radiographic archives at the Malmö University Hospital, where all radiographs are saved since a century, were evaluated. Fractures of the radial head and neck were classified according to the by Broberg and Morrey modified Mason classification. A Mason type I fracture is a less than 2 mm displaced fracture of the radial head or nec
The aim of this thesis was to examine the importance of environmental, non-cognitive, and person-based variables for memory performance in old adults. Study I was conducted in cooperation with the Gerontology Research Centre and the Department of Psychology in Lund. The investigation included 69 people with an age-range from 55-94 years and examined if certain personality factors could explain th
