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The incidence and prevalence of heart failure (HF) has increased successively over the past decade. Mortality and morbidity is high. It is the most common cause of hospitalisation in the elderly and has been estimated to account for 1-3% of health care costs in many countries. There is a need therefore, to improve care for HF patients. However, due to limited economic resources, this must be done
Deep cuts in carbon emissions to avoid dangerous climatic change will require fundamental transformations of the energy and transport systems. This is an enormous challenge for society and the political system. In order to tackle this challenge, we argue that it will be necessary to develop new institutions and institutional practices that address and give priority to long-term climate policy obje
This thesis deals with how computationally effective lattice models could be used for inference of data with a continuous spatial index. The fundamental idea is to approximate a Gaussian field with a Gaussian Markov random field (GMRF) on a lattice. Using a bilinear interpolation at non-lattice locations we get a reasonable model also at non-lattice locations. We can thus exploit the computational
In order to define critical situations in which speed adaptation is unsatisfactory a number of traffic safety researchers from 20 countries were asked to rate the seriousness of various situations. The proportion of injury accidents in the different situations were also considered. Expert judgements, the high proportion of injury accidents and the increased accident risks compared to "normal" cond
Abstract in UndeterminedThe aim of this paper is to argue for the need of democratic control of expert committees generally and ethical expert committees specifically. Expert committees including ethical expert committees with the commission to give advice to political decision-makers are often criticized for not being democratic. This criticism point at different aspects of expert committees: com
The legislated goals for Master of Science in Engineering educations include goals like having the ability to critically, independently and creatively identify, formulate and handle complex problems as well as participate in research and development work and thus contribute to knowledge development. One might therefore argue that these educations are required to promote a deep approach to learning
In our experience, doctoral supervision seminars and training (and associated literature) focus the supervisor-student relationship to an extent largely leaving aspects of learning, enculturation and subject discipline aside. In 2006-2008 we therefore developed and implemented a 3-week programme compulsory for new primary research supervisors (docent degree) with a wider scope, at the faculties E
Queer/ed children and young people inhabit a space that seems nicely delineated by shamed biographies, fearful prospects and ignorance. In mainstream accounts, queer/ed children and young people are often un/represented through invisibility or drama, between exoticism and pity. ‘Children’ and notions of ‘the best interest of the child’ are used to dramatize and limit societal negotiations of sexua
Socio-economic differences in health and mortality are substantial and increasing today in many developed countries. The sources of these differences remain debated. There is an expanding literature showing that early-life conditions are linked to health in adulthood and old age. However, our knowledge about whether beneficial treatments in early life influence later health is still limited. Using
Objective. Previous research has shown that elderly and disabled travelers using Special Transportation Services (STS) are injured without being involved in a vehicle crash. In order to estimate the true costs for these vehicle-related injuries, the focus needs to be adjusted towards an incident/traveler-oriented perspective. The aim of the project was thus to utilize such a perspective, in order
Recent genome-wide association studies confirm that human leukocyte antigen (HLA) genes have the strongest associations with several autoimmune diseases, including type 1 diabetes (T1D), providing an impetus to reduce this genetic association to practice through an HLA-based disease predictive model. However, conventional model-building methods tend to be suboptimal when predictors are highly poly
I denna rapport analyseras effekterna av sänkta parkeringsnormer för bostäder för invånarna i det centrumnära, och relativt nybyggda, bostadsområdet Porslinsfabriken i Göteborg. Porslinsfabriken är med en relativt låg parkeringsnorm på 0,57 platser per lägenhet ett bra exempel på en parkeringspolitik som förs i alltfler kommuner. Resultatet visar att 19 procent av hushållen har minskat bilinnehave
Purpose: We studied treatment delay, and the impact on disease specific survival and stage progression in a series of patients who had undergone cystectomy. Materials and Methods: All 141 patients underwent radical cystectomy between 1990 and 1997 due to locally advanced bladder cancer. Treatment delay was defined as time from pathological confirmation of invasive disease to performance of cystect
Aims: Recently, drug-eluting balloons have received a guideline class IIa recommendation in the treatment of in-stent restenosis after bare metal stent implantation. It is not known if different balloons perform equally. Using a large real world registry, restenosis frequency was reported for two drug-eluting balloons. Methods and results: From April 2009 until September 2011, 1,129 patients w
Genome-wide association studies (GWAS) have long relied on proposed statistical significance thresholds to be able to differentiate true positives from false positives. Although the genome-wide significance P-value threshold of 5 × 10(-8) has become a standard for common-variant GWAS, it has not been updated to cope with the lower allele frequency spectrum used in many recent array-based GWAS stud
This paper reviews current issues regarding short-term (i.e. for surgery and invasive procedures) and long-term (i.e. regular infusions to prevent bleeding on a permanent or temporary basis) prophylaxis treatment using replacement concentrates for patients with von Willebrand disease (VWD) who do not respond satisfactorily to desmopressin. The standard treatment of these patients is with factor co
In preterm infants, low levels of Insulin like growth factor 1 (IGF-I) have been associated with impaired growth and retinopathy of prematurity. Our objective was to study safety and pharmacokinetics of intravenously administered rhIGF-I with its binding protein 3 (rhIGFBP-3) to preterm infants. At 3 days chronological age, an intravenous 3 hours infusion of rhIGF-I/rhIGFBP-3 was administered foll
