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Aging associates with impaired pancreatic islet function and increased type 2 diabetes (T2D) risk. Here we examine whether age-related epigenetic changes affect human islet function and if blood-based epigenetic biomarkers reflect these changes and associate with future T2D. We analyse DNA methylation genome-wide in islets from 87 non-diabetic donors, aged 26-74 years. Aging associates with increa

The courtroom work of defense lawyers has received surprisingly little sociological attention. What does a defense lawyer actually do in court? How do defense lawyers represent their client beyond the hard paragraphs of the law? By studying this phenomenon in a context where the scope for expressive gestures is limited, it is possible to gain a greater understanding into the often subtle ways in w

In the 2000s, same sex partnership laws, new reproductive technologies, and legislation rendering lesbian couples and single women eligible for state-funded assisted reproduction with donated gametes in the Scandinavian nations has resulted in significant changes in family formation. Drawing on two separate qualitative studies, this paper scrutinizes Scandinavia’s alleged progressive LGBTQ politic

PURPOSE: Brief Admission by self-referral (BA) is a standardized crisis-management intervention for individuals with self-harm and risk for suicide. This study explored relatives' experiences of BA. Relatives' perspectives may contribute to an increased understanding of the effects of BA given the relatives' role as support and informal caregivers as well as being co-sufferers.METHODS: Fourteen re

The increased electrification of society and the development of smart grids are often seenas central in the transition towards a more sustainable and secure energy system and necessaryto address the challenges of increasing energy demand and limited resources. Thereare many visions and ideas on what a smart grid is or could be. While most research relatedto environmental impacts on the smart grid

Hybridization allows adaptations to be shared among lineages and may trigger the evolution of new species1,2. However, convincing examples of homoploid hybrid speciation remain rare because it is challenging to demonstrate that hybridization was crucial in generating reproductive isolation3. Here we combine population genomic analysis with quantitative trait locus mapping of species-specific trait

Postural tachycardia syndrome (POTS) is a chronic autonomic disorder characterized by excessive heart rate elevation upon standing or head-up tilt, in the absence of orthostatic hypotension. This debilitating condition affects primarily young to middle-aged individuals, particularly women, and substantially influences quality of life. The main presenting symptoms are lightheadedness, palpitations,

Recent research suggests that to help their preferred coalition win an election, voters are willing to vote for a political party other than their preferred choice. In this field, voting for smaller parties under proportional representation is an under-studied feature. A crucial factor to estimate the chances for smaller parties is polls. In this study, we analyze the influence of opinion polls on

This article summarises the state of the science on the role of the gut microbiota (GM) in diabetes from a recent international expert forum organised by Diabetes, Diabetes Care, and Diabetologia, which was held at the European Association for the Study of Diabetes 2023 Annual Meeting in Hamburg, Germany. Forum participants included clinicians and basic scientists who are leading investigators in

A strong and prevailing innovation imperative is sweeping across the public sector and despite a growing literature on public sector innovation (PSI), the actors driving these processes tend to end up in the background of analysis. Based in an analytical framework of narrative theory and organization studies, and the efforts to introduce Social Impact Bonds (SIB) in Sweden as empirical case, the a

The aim of this study was to add knowledge of the longitudinal associations between gaming and emotional closeness between parents and their children. We hypothesized that parent–child emotional closeness was linked to less gaming activity over time and that more gaming activity was linked to less parent–child emotional closeness over time. We also tested the moderating effect of child gender on t

The article examines the innovation-job quality-employment nexus in social and health care in the United Kingdom and Sweden, respectively. Through seven case studies carried out with a common methodological and analytical framework in the two countries, it shows how the constraining factors of fiscal strictures derived from budgetary regimes and chronic labor shortages have two key consequences fo