Background: Cancer of unknown primary (CUP) is diagnosed at a metastatic stage but no diagnostic effort is spared to find the primary cancers because these will guide the treatment. Consequently, the diagnostic work-up for CUP is more comprehensive than for any other cancer, resulting in detection of second cancers unrelated to CUP. We want to use the detection rate of second cancers as a measure

Three large-scale Echovirus (E) epidemics (E4,E16,E30), each differently associated to the acute development of diabetes related autoantibodies, have been documented in Cuba. The prevalence of islet cell autoantibodies was moderate during the E4 epidemic but high in the E16 and E30 epidemic. The aim of this study was to evaluate the effect of epidemic strains of echovirus on beta-cell lysis, beta-

BACKGROUND: Proper treatment of lymph node-negative breast cancer depends on an accurate prognosis. To improve prognostic models for this disease, we evaluated whether an immunohistochemical marker for proliferating cells, Ki-S2 (a monoclonal antibody that binds to a 100-kd nuclear protein expressed in S, G2, and M phases of the cell cycle), is an accurate indicator of prognosis.METHODS: We studie

En ny europeisk studie granskar hur allmänheten i sex länder ser på organtransplantationer och postnatala genetiska test. Det rör sig om Cypern, Österrike, Tyskland, Frankrike och Sverige. I undersökningen framkommer att de tillfrågade personernas funderingar följer två övergripande spår: Här finns å ena sidan tankar om den medicinska utvecklingens potential, å andra sidan reflektioner rörande desRecent developments in the field of biomedicine do not only constitute a challenge for the health care systems of modern societies. They also have a profound impact on the core concepts of individual and collective life. The corresponding changes of individual and collective identities take place within the framework of different historically shaped national conditions and traditions. This leads t

Value Based Management (VBM) has become a common tool for evaluating corporate strategies and projects from the perspective of shareholder value maximization, and can be an important input for corporate compensation systems. But traditional VBM frameworks make no systematic effort to distinguish between changes in performance attributable to macroeconomic fluctuations beyond management's control a

Objective-To compare four different inception cohorts of patients with early rheumatoid arthritis (RA) with respect to treatment strategies, disease activity, and outcome during a five year follow up period. Method-Data from cohorts of patients with early RA, with a standardised assessment at least every six months for five years from four different centres, were included in one database. Owing to

I here propose a modification of the English butterfly census method (Pollard 1977) for studies of large areas with a relatively low density of butterflies. The transect line should not be more than 10 m from any point in open terrain and open forests, but only 5 m from sunny edges and patches with a high density of flowers. The transect line is adjusted between visits to most intensively cover si

A coupled lake-catchment model was developed to examine the controls on lake-level changes in currently overflowing lakes during Holocene. The lake energy-balance is simulated as the one-dimensional vertical heat transfer by eddy diffusion and convective mixing. The accumulation and ablation of lake ice, and snow cover on the ice, is simulated thermodynamically. The lake water-balance is given by