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New Kids on the Block : The Emerging Role of YAP/TAZ in Vascular Cell Mechanotransduction

YAP and TAZ are transcriptional coactivators controlled by the Hippo signaling pathway and by actin dynamics, and that are critical for cell growth and organ size control. YAP and TAZ are exquisitely sensitive to mechanical cues, such as substrate stiffness and shear stress, and the realization is growing that they play roles in arterial remodeling and aneurysm formation. This chapter discusses ho

Association Between Bone Mineral Density and Autoantibodies in Patients With Rheumatoid Arthritis

Objective: Autoantibodies, such as anti–citrullinated protein antibodies (ACPAs), have been described as inducing bone loss in rheumatoid arthritis (RA), which can also be reflected by bone mineral density (BMD). We therefore examined the association between osteoporosis and autoantibodies in two independent RA cohorts. Methods: Dual x-ray absorptiometry (DXA) of the lumbar spine and left hip was

Ecological compensation and mineral extraction : a rocky path

Ecological compensation builds on the idea of substitutability, meaning that destroyed values can be replaced or substituted with new values that are equal to the ones lost. Through this equivalence between “lost” and “gained” values compensation is meant to allow dynamic economic development without causing irreversible biodiversity loss. Compensation is increasingly used as a means to reduce the

Hinderbelysning – ett hinder för utbyggnaden av vindkraft? En studie om kraven på högintensiv hinderbelysning på vindkraftverk i Sverige

Enligt nationella föreskrifter ska vindkraftverk över 150 m i totalhöjd markeras med högintensivt vitt blinkande ljus för att säkerställa att vindkraftverken är synliga för luftfarten. Samtidigt som hinderbelysningen är viktig för flygsäkerheten kan dock ljuset upplevas som störande av närboende. Syfte med denna studie är därför att utreda konflikten mellan vindkraftsetableringar och närboendes häAccording to national regulations, wind turbines over 150 m in total height must be marked with high-intensity white flashing light to ensure that the wind turbine is visible to aviation. However, while the obstacle lighting is important for aviation safety it can also be perceived as disturbing to nearby residents. The purpose of this study is therefore to investigate the conflict between wind po

Precision i gärningsbeskrivningen - Om gärningsbeskrivningens precision i förhållande till rättssäkerhet

När åklagaren väcker åtal med stämningsansökan kräver 45:4 RB att han preciserar anklagelsen i vissa hänseenden som tid, plats, åberopat lagrum med mera. Detta sätter ramen för processen enligt 30:3 då åklagarens gärningsbeskrivning binder domstolen i deras prövning. Samtidigt får även EKMR betydelse för gärningsbeskrivningen då dessa bestämmelser ska läsas i ljuset av artikel 6 EKMR om rätten tilWhen the prosecutor presses charges according to 45:4 RB it requires that the prosecutor specify certain aspects of the charge such as time and place of the crime. It also requires him to specify what paragraph he thinks constitutes the crime. This binds the court trial and as such it provides the frame for the process. The ECHR is also of importance because of article 6 which states the right to

A risk assessment of uranium in drinking water

Naturally occurring uranium is known to give rise to adverse renal effects in various species after ingestion. This short review of uranium toxicity focus on three epidemiological studies on drinking water which are compared with a pivotal study in experimental animals used as a basis for limits of uranium in drinking water or guidelines in several countries. These studies are scrutinized and disc

Socialtjänslagens värdesystem. En analys av dess praktiska innebörd i sociala utredningar om barn.

The Social Services Acts’ Value System – An Analyze of its Practical Meaning in Social Investigations on Children This article discusses the relation between legal and practical norms, on the basis of a model over the norms main components. The focus is on the norms value component, and the question is how the value of a legal norm is implemented in that practice which the norm is aimed to regula

A visual self-image of legal authority: 'The temple of law'

The focus of this article is on the legal profession's visual self-image of legal authority. It takes a departure from the themes of visual legal communication and discusses the relationship between text and pictures in the legal domain. The discussion concludes with a reflection on the consequences of the modern pictorial evolution. Bearing this discussion in mind, will the development of the ICT

Borrowings - A Source of Innovation in the Class of Interjections

The present article is part of a larger project investigating the various types of linguistic change that affected and might affect the word class traditionally known under the label of interjection. The results of our research, as outlined here, concern the inter-linguistic mobility of units, i.e., borrowings, which in the source language can be (but not necessarily) interjections, and which are