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The Limited Clinical Utility of Testosterone, Estradiol, and Sex Hormone Binding Globulin Measurements in the Prediction of Fracture Risk and Bone Loss in Older Men

Measurement of serum testosterone (T) levels is recommended in the evaluation of osteoporosis in older men and estradiol (E2) and sex hormone binding globulin (SHBG) levels are associated with the rate of bone loss and fractures, but the clinical utility of sex steroid and SHBG measurements for the evaluation of osteoporosis in men has not been examined. To evaluate whether measurements of T, E2,

High frequency of multiple melanomas and breast and pancreas carcinomas in CDKN2A mutation-positive melanoma families

BACKGROUND: : Inherited mutations in the CDKN2A tumor suppressor gene, which encodes the p16(INK4a) protein, and in the cyclin-dependent kinase 4 (CDK4) gene confer susceptibility to cutaneous malignant melanoma. We analyzed families with two or more cases of melanoma for germline mutations in CDKN2A and CDK4 to elucidate the contribution of these gene defects to familial malignant melanoma and to

Assessing the external validity of algorithms to estimate EQ-5D-3L from the WOMAC

Background: The use of mapping algorithms have been suggested as a solution to predict health utilities when no preference-based measure is included in the study. However, validity and predictive performance of these algorithms are highly variable and hence assessing the accuracy and validity of algorithms before use them in a new setting is of importance. The aim of the current study was to asses

Stump harvesting can affect the emissions of methane and nitrous oxide

The emissions of the greenhouse gases methane and nitrous oxide wereconsistently low in relation to carbon dioxide emissions at four experimental sites.Stump harvesting did not seem to affect the emissions of methane and nitrousoxide. Soil moisture was a major factor for methane emissions – independent ofsoil treatments. These studies are the first ones in the world and should beinterpreted with c

Plasma levels of the interleukin-1-receptor antagonist are lower in women with gestational diabetes mellitus and are particularly associated with postpartum development of type 2 diabetes

Diabetes mellitus is a group of diseases characterized by chronic hyperglycemia. Women who develops hyperglycemia for the first time during pregnancy receive the diagnosis gestational diabetes mellitus (GDM). Presently, there is no consensus about the diagnostic criteria for GDM. A majority of these women subsequently develop postpartum overt diabetes making it important to identify these patients

What Makes Institutional Long-Term Care the Most Appropriate Setting for People With Dementia? Exploring the Influence of Client Characteristics, Decision-Maker Attributes, and Country in 8 European Nations

To explore the extent to which client characteristics, decision-maker attributes, and country influence judgments of institutional long-term care (ILTC) appropriateness for people with dementia. Design, setting, and participants: A total of 161 experts in dementia care from 8 European countries reviewed a series of 14 vignettes representing people with dementia on the cusp of ILTC admission and in

Hybrid Organising in Social Entrepreneurship: How Do Founders of Social Ventures Experience the Tensions in the Areas of Acquiring and Allocating Resources?

Purpose – This study attempts to advance our understanding of social ventures as organisational hybrids by seeking the founder’s experience of selected areas of tensions. We take extant literature on social entrepreneurship and hybrid organising as a point of departure to examine the experiences of practitioners. We aim to answer the question: ‘How do founders of social ventures experience the ten

Kraftpaket på väg - Incitament för kunder samt marknader för en framtida aggregator av V2G

I ett framtida samhälle som inkluderar alltmer intermittent elproduktion och mindre svängmassa är det viktigt att hitta nya, snabba frekvensreglerande resurser för att bibehålla ett stabilt elsystem med säker energileverans. Ett exempel på en sådan resurs är batterier. En teknik som har fått alltmer uppmärksamhet de senaste åren är den så kallade ''Vehicle To Grid'' (V2G) teknologiIn a future society with an increasing amount of intermittent electricity production and lower inertia, it is important to find new, fast frequency-regulating resources to maintain a stable electrical system with a safe energy supply. One example of such a resource is batteries. A technology that has received increasing attention in recent years is the so-called ''Vehicle To Grid''

Litologi, sedimentologi och kolisotopstratigrafi över krita–paleogen-gränsintervallet i borrningen Limhamn-2018

Krita-paleogen-gränsen har länge varit central i diskussioner mellan forskare runt om i världen, då den markerar/sammanfaller med utdöendet av 75% av jordens arter till följd av ett enormt asteriodnedslag på Chicxulúbhalvön i Mexiko. Gränsintervallet är vida utbrett i sedimentära lagerföljder som bildades under denna tid, och kan identifieras genom sina unika kemiska egenskaper och karakteristiskaThe Cretaceous-Paleogene boundary has long been a center of discussion amongst scientists as it marks the extinction of 75% of all species on Earth. This mass extinction event was probably caused by an enormous asteroid impact event in what is now Mexico. The boundary interval is easily identified in the sedimentary geological record because of its unique chemical properties as well as its charact

Klandergrunden handläggningsfel – en för parterna svårligen förutsebar bestämmelse? – En studie av innehållet i 34 § 1 st. 7 p. lagen om skiljeförfarande samt en utblick mot grova rättegångsfel i civilprocessen

Skiljeförfarande som tvistlösningsform har blivit allt vanligare mellan kommersiella parter, till stor del på grund av dess effektivitet och slutgiltighet. Skiljedomar kan enbart upphävas enligt ett begränsat antal grunder i 34 § 1 st. lag (1999:166) om skiljeförfarande (LSF). En av dessa klandergrunder kan åberopas om skiljenämnden begått ett handläggningsfel utan parts vållande som sannolikt påv

Lekmäns delaktighet i rättskipningen - En utredning av argumenten för och emot det svenska nämndemannasystemet ur ett rättsutvecklingsperspektiv

Förekomsten av juridiskt oskolade som ett inslag i den dömande verksamheten, är ett fenomen som existerar världen över. I Sverige har institutionen med s.k. nämndemän länge varit en del av rättssystemet. Dess rötter härstammar från det medeltida samhället, men systemet har under åren modifierats flertalet gånger och inflytandet på rättskipningen har varierat. Det huvudsakliga syftet och dess vikti