OBJECTIVE: To investigate gastrointestinal infection episodes (GIEs) in relation to the appearance of islet autoantibodies in The Environmental Determinants of Diabetes in the Young (TEDDY) cohort.RESEARCH DESIGN AND METHODS: GIEs on risk of autoantibodies against either insulin (IAA) or GAD (GADA) as the first-appearing autoantibody were assessed in a 10-year follow-up of 7,867 children. Stool vi

This chapter focuses on a specific kind of governance namely sustainability governance. Combatting climate change and social inequalities calls for governance systems specifically directed to corporate sustainability. Today our companies are fiercely working on setting up efficient systems for sustainability governance. In this chapter, the reader will learn what a sustainability governance system

This special issue of Ethnologia Europaea explores new paths for our scientific disciplines within the expanding field of medical humanities. Medical humanities have seen a significant expansion in recent years, creating new research foci and leading to collaborations both within and outside of the humanities. As it is a growing academic field, we argue that it is necessary to be part of the medic

The aim of this thesis was to better understand the role of antigen presenting cells (APC) in the development of diabetes in the nonobese diabetic (NOD) mouse. We have shown that DC and Mphi that infiltrate the islets of Langerhans produce tumour necrosis factor-a (TNF-a), a cytokine known to contribute to the pathogenesis in the early stages of diabetes development. TNF-a is produced from the ear

Utilities, such as steam or cooling water, have shown to play an important role within the process industry, since a malfunctioning utility is a plant-wide disturbance that can lead to large revenue losses due to reduced production quantities. This work focuses on identifying disturbances on utilities that give economical consequences. Measures of utility availability and area availability are int

Hospital care is a joint production involving a wide range of services; ranging from medical services to support services to hotel services. This paper, focusing on the cooperation between these services, models the internal organization of public hospitals. The analysis is based on the property rights approach to organization (aka the Grossman-Hart-Moore model) and adopts it to the realities of p

The aim of this study was to delineate management zones by using topographical data, and to investigate how these management zones relate to soil parameters and yield. Elevation, as well as soil and yield data, were sampled in the field. Digital elevation models have been created, and the topographical parameters of slope, aspect and drainage area, estimated. Management zones have been delineated

Regional growth models leave a large share of variation unexplained. While we should continuously aim to improve these models, the unique combination of conditions and human agency in each region will also invariably lead to region-specific growth trajectories. Theoretically, we should thus expect systematic deviations from growth predictions. We propose an approach to explore these unexplained de

ABSTRACT: In this observational study, by the use of a multiplex proteomic platform, we aimed to explore associations between 92 targeted proteins involved in cardiovascular disease and/or inflammation, and phenotypes of deteriorating vascular health, with regards to ethnicity.Proteomic profiling (92 proteins) was carried out in 362 participants from the Sympathetic activity and Ambulatory Blood P

A pandemic is a crisis and as such, in many ways, an entirely new situation . It is a situation in which there are scientific as well as societal uncertainties and where the routines of everyday life are overturned . The Covid-19 pandemic has made visible already established social structures and inequalities, but it has also exacerbated existing power relations and vulnerabilities . In this artic

The semantics of programming languages comprise many concepts that are alternatives to each other, such as by-reference and by-value parameter passing. To help teach these concepts, Diwan et al. introduced the programming language Mystery, with fixed syntax but configurable semantics, and described how this language enables new approaches to teaching programming languages concepts. In this paper,