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Epigenetic variation has been linked to several human diseases. Proliferative diabetic retinopathy (PDR) is a major cause of vision loss in subjects with diabetes. However, studies examining the association between PDR and the genome-wide DNA methylation pattern are lacking. Our aim was to identify epigenetic modifications that associate with and predict PDR in subjects with type 1 diabetes (T1D).

The following presentation is primarily intended to stimulate and facilitate a future development towards an improved situation for a reliability based structural fire engineering design of timber structures. The state of the art is reviewed and a structure of a design guide or a model code is outlined. The document is written in a partially operational manner, allowing practical application for s

The inflammatory mediator procalcitonin (PCT) has previously been associated with prognosis in myocardial infarction, cancer and sepsis patients. The importance of PCT in the general population is currently unknown. Our aim was to assess the relationship between plasma PCT and the risk of all-cause and cause-specific mortality in apparently healthy individuals with no previous history of cardiovas

Salt-induced elevation of the endogenous digitalis like sodium pump ligand marinobufagenin (MBG) in the Dahl salt-sensitive rats resulted in elevated blood pressure (BP). Here, we tested, in humans, whether MBG levels are related to ambulatory 24-h BP (ABP), controlled long-term increase of salt-intake induces changes in MBG and any salt-induced change in MBG is related to salt sensitivity.

Atrial fibrillation (AF) is prevalent and there is a clinical need for biomarkers to identify individuals at higher risk for AF. Fixed throughout a life course and assayable early in life, genetic biomarkers may meet this need. Here, we investigate whether multiple single nucleotide polymorphisms together as an AF genetic risk score (AF-GRS) can improve prediction of one's risk for AF.

Precision medicine utilizes genomic and other data to optimize and personalize treatment. Although more than 2,500 genetic tests are currently available, largely for extreme and/or rare phenotypes, the question remains whether this approach can be used for the treatment of common, complex conditions like obesity, inflammation, and insulin resistance, which underlie a host of metabolic diseases.

Aortic stenosis (AS) shares risk factors with atherosclerotic vascular disease. Carotid intima-media thickness (IMT) and plaque may reflect the cumulative damage from exposure to different atherosclerotic risk factors. We examined the relationship of carotid IMT and plaque with incident AS in a prospective population-based study.

A small population of Primula elatior has recently been found in a virgin swampy forest close to the southeastern shore of lake Ringsjon in Stehag parish. Here it grows in fully natural vegetation together with e.g. Anemone ranunculoides, Paris quadrifolia, Listera ovata, Ranunculus auricomus and Viola epipsila and there are no reasons to suspect that the population is anything but spontaneous. Un

Neurotensin is released from the gut after fat intake and has a role in appetite regulations. Proneurotensin is a stable fragment of the neurotensin precursor hormone and fasting plasma proneurotensin levels have shown to be significantly associated with the development of cardiovascular disease in middle aged participants of the Malmö Diet and Cancer Study. Here, we aimed at replicating the initi

“The Future is distributed: a vision of sustainable economies” is a collection of case studies on distributed economies, a concept describing sustainable alternatives to the existing business models. The authors of this publication are international Masters students of the Environmental Sciences, Policy and Management Programme at the International Institute for Industrial Environmental Economics

I svensk rätt men även av Europadomstolen har det ansetts möjligt att tillmäta en tilltalads tystnad eller icke trovärdiga förklaring en för denne negativ bevis-verkan genom åläggandet av en förklaringsbörda. Uppsatsens syfte är att un-dersöka om denna förklaringsbörda i ljuset av bevisrättsliga principer samt rättspsykologisk forskning är lämplig att använda i brottmål. För att uppfylla syftet ko