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Oral anticoagulation treatment in atrial fibrillation - To bleed or not to bleed, that is the question

Background: Oral antigoagulation treatment (OAT) with warfarin have a narrow therapeutic window and patients exhibit a highly variable doseresponse that is attributable to genetic, disease-related,and environmental factors as well as prescription and nonprescription drugs, dietary vitamin K and alcohol. The effect of warfarin treatement on blood coagulation is measured using international normaliz

Skriftpraktiker, diskursiva praktiker och analytisk konsekvens

Literacy practice and discursive practice are two distinct concepts, belonging to different research traditions (new literacy studies, NLS, and critical discourse analysis, CDA). This article is an effort to enlighten the discussion of these concepts by comparing the history and scope of the concepts, the research interest and the different research methods used. Exemplifying with an analysis of 1

Single nucleotide polymorphisms in the 20q13 amplicon genes in relation to breast cancer risk and clinical outcome

The 20q13 region is frequently amplified/overexpressed in breast tumours. However, the nature of this amplification/overexpression is unknown. Here, we investigated genetic variation in five 20q13 amplicon genes (MYBL2, AURKA, ZNF217, STK4 and PTPN1) and its impact on breast cancer (BC) susceptibility and clinical outcome. As a novel finding, four polymorphisms in STK4 (rs6017452, rs7271519) and A