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Objective: Vascular endothelial growth factor D (VEGF-D) has important functions in lymphangiogenesis and angiogenesis. High plasma levels of VEGF-D have been associated with incidence of heart failure. The association of VEGF-D with atrial fibrillation (AF) and stroke is unclear and we hypothesised that VEGF-D could also be associated with incidence of AF and ischaemic stroke. Methods: VEGF-D was

Habitat loss and fragmentation threaten the long-term viability of innumerablespecies of plants and animals. At the same time, habitat fragmentation mayimpose strong natural selection and lead to evolution of life histories with possibleconsequences for demographic dynamics. The Baltic populations of the Glanvillefritillary butterfly (Melitaea cinxia) inhabit regions with highly fragmented habitat

There is an increasing global interest to support research areas that can assist in understanding disease and improving patient care. The National Cancer Institute (NIH) has identified precision medicine-based approaches as key research strategies to expedite advances in cancer research. The Cancer Moonshot program (https://www.cancer.gov/research/key-initiatives/moonshot-cancer-initiative) is the

Political comedy in various forms is increasingly popular among media audiences, directing scholarly attention to issues like shifting news habits and values, and further, potential impacts on civic cultures. But with the exception of media effects studies, audiences of political com-edy remain largely under-researched (Marchi 2012; Jones 2013).This paper deals with young adult audiences of politi

There is a growing interest within place branding research for how experiences of safety influence the image of the city (e.g. Coaffee and Van Ham, 2008).Previous research demonstrates that fear is socially constructed and amplified by mass media (Avraham and Ketter, 2008) and social media (Doosti et al., 2016; Jansson, 2018). The realm of media has become more complex in an era characterised as p

Background: Calprotectin, a neutrophil activation marker, is a promising diagnostic biomarker for infection and sepsis, but its usefulness in the emergency department (ED) is unclear. The aim of this study was to investigate the diagnostic value of calprotectin for sepsis and the source of infection in the ED. Methods: A total of 583 prospectively included patients presenting with suspected sepsis

Announced in this Comment and in collaboration with Nature Medicine is the convening of the Data-Driven Decision Support in Obesity Management Commission, to promote adequate scientific evidence to support obesity management across global populations.

Background: The major genetic high-risk of developing autoimmune diabetes are HLA-DR3DQ2 and HLA-DR4DQ8 haplotypes. Their importance in Latent Autoimmune Diabetes in Adults (LADA) has only been partly elucidated. Here we aimed to dissect their impact on autoimmunity, diabetic phenotype, and comorbidity. Methods: Data from individuals with LADA were collected from two all-population based surveys,

Which biological and molecular processes contribute to the pathophysiology of orthostatic hypotension? Orthostatic hypotension is associated with alterations in coagulation, complement, and extracellular matrix pathways, pointing to molecular effects beyond blood pressure regulation and broader vascular and inflammatory phenotypes.

Abstract.– In ectothermic invertebrates, high temperatures generally accelerate developmental rates and decrease adult body sizes. However, such temperature effects on body size could have contrasting fitness effects in the two sexes, as under certain circumstances in some species small males may have higher mating success, but large female insects almost invariably have higher fecundity. Here we

Introduction: External aortic compression is used to reduce excessive blood loss in childbirth. However, it has never been evaluated for the prevention of postpartum haemorrhage. This study aims to investigate whether routine external aortic compression, in patients undergoing elective caesarean delivery, is an effective and acceptable preventive method to reduce severe postpartum haemorrhage. Met