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Migratory connectivity describes to which degree different breeding populations have distinct (non-overlapping) non-breeding sites. Uncovering the level of migratory connectivity is crucial for effective conservation actions and for understanding of the evolution of local adaptations and migratory routes. Here we investigate migration patterns in a passerine bird, the great reed warbler Acrocephal
This thesis focuses on the pedagogue as a social being and how she or he experiences the social life in preschools and schools in Tallsten. In 1996, the child-care and education authorities in Tallsten introduced a new manner of thinking and working based on the communicative pedagogy. The idea of communicative pedagogy was origanlly put forth by the Danish teacher Lars Rokkjaer. One of the goals
The neutrophil granulocytes have a critical role in innate immunity in particular through phagocytosis of microorganisms. Their cytoplasmic granule subsets store digestive enzymes and antibiotic proteins that are released during this event. During the passage in the secretory pathway the granule proteins are retrieved from constitutive secretion to become sorted for storage. The aim of this thesis
Adipose tissue is the main site of energy storage of the body and an important endocrine organ. Knowledge of the regulation of fat metabolism and the endocrine factors secreted by the adipocyte is crucial for the understanding of diseases such as obesity and diabetes. Insulin is the main antilipolytic hormone. Protein kinase B (PKB) and phosphodiesterase 3B (PDE3B) are both phosphorylated and acti
In this thesis we have used cells dissected from the lateral ganglionic eminence (LGE), the medial ganglionic eminence (MGE), and the cortical primordium of the embryonic mouse forebrain. The tissue was dissected from either i) wild-type mice, ii) green fluorescent protein (GFP)-, or iii) Gtv-a-expressing transgenic mice, and subsequently grown and expanded in vitro using two different protocols.
This study aims at clarifying the role of NO in the immunosuppression induced by in vivo tumor growth and by tumor immunotherapy, and determining whether the inhibition of NO production can be used as an adjuvant in tumor immunotherapy. We have shown previously that tumor cells, glioma (N32) and colon carcinoma (H1D2), when genetically engineered to express such immune stimulatory cytokines as IFN
Intestinal ischemia and reperfusion (I/R) is a potentially life-threatening condition, sometimes leading to a systemic inflammatory response and the potential development of the multiple organ dysfunction syndrome. The overall aim of the thesis was to study the effects of intestinal I/R on pulmonary function with special emphasis on removal of excess alveolar fluid, pulmonary endothelial barrier p
Prostanoids are ubiquitously distributed lipid signaling molecules derived from arachidonic acid, that exhibit numerous and diverse biological effects in a variety of physiological and pathophysiological conditions. The cell surface receptors for the prostanoids belong to the family of G protein-coupled receptors. In this thesis, the author describes the cloning and structural characterization of
Atomic data are needed in many different areas of science and technology. Examples of users are the astronomical community and the lighting industry. In this work, the purpose of the projects has been to produce reliable atomic data needed to solve specific astrophysical problems. Oscillator strengths, which are needed when analysing stellar absorption spectra as well as spectra of emission line o
This thesis concerns the bioactive peptides lactoferricin and ubiquitin and findings suggesting that they have ability to modify the risk of cancer. It is known that components in bovine milk may improve human health and modify the risk of diseases. Examples of such compounds are bioactive peptides, i.e. peptides with an effect on the body beyond the purely nutritional. Using cell culture as a mod
Allergic diseases currently affect a third of the population in the industrialized parts of the world. Despite this, the cellular and molecular mechanisms involved in the induction and activation of allergic diseases are not fully clarified. Dendritic cells (DCs) link the innate and adaptive immunity and play vital roles in protective immunity against pathogens, as well as in inducing tolerance t
