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Hyaluronan has been found in the eye in varying amounts and at different sites. It is involved in physiological and pathological processes, though many aspects of its bio-logi-cal functions are still unclear. We have studied the role of iris tissue in hyal-uro-nan production in the anterior segment of the eye, and its changes after trauma. After peripheral iridectomy or argon laser treatment, the
Organic acid anhydrides (OAAs) are low molecular weight chemicals used in the industry for manufacturing of plastics such as epoxy resins. Exposure to these chemicals may lead to symptoms from the eyes and the respiratory tract in form of conjunctivitis, rhinitis and asthma. In many workers production of specific IgE antibodies are induced suggesting that a type-1 allergy mediated mechanism is inv
Electrostatic interactions in bio-molecular systems are important not only in the living cell but also in more technical applications. Using molecular simulation as well as approximate theories the properties of a number of aqueous protein solutions have been studied. This includes interactions with other proteins, protons, charged membranes as well as flexible polyelectrolytes. The focus is on el
A thorough physical-chemical characterisation of alkylglycosides has been performed. The effects of temperature, salt, concentration and deuterium exchange on the self-aggregation of n-nonyl-b-D-glucoside (b-C9G1) and n-tetradecyl-b-D-maltoside (b-C14G2) have been studied in dilute solutions by static and dynamic light scattering, neutron scattering, rheology, capillary viscometry and tensiometry.
Thermal radiation is an important physical phenomenon in combustion environments. For the understanding of existing- and the design of new combustion environments computational modelling is a useful tool as it can describe the different transport phenomena. This thesis has focused on studying thermal radiative property models of the participating media, gases and particles. Two specific combustion
The diagnostic value of modern fast pulse sequences and breath-hold technique was evaluated in a prospective study of patients with suspected biliary diseases. The cost-effectiveness of MRI compared to ultrasound was calculated. Characteristics of acute cholecystitis and cholangitis were evaluated, the appearance of bile in MRCP with reference to its chemical and physical properties was studied, a
Aggregation in protein-surfactant systems have been studied with the ambition of reaching a deeper understanding of the balance of the interaction forces involved. A pure system with maximized electrostatic interactions has been used. The approach has been to use a step-wise sample preparation where initially a stoichiometric protein-surfactant salt is precipitated and freeze-dried. Secondly, the
Atomic layer deposition (ALD) is a thin-film manufacturing process in which the growth surface is exposed to non-overlapping alternating injections of gas-phase chemical precursor species separated by intermediate purge periods to prevent gas-phase reactions. ALD is characterized by sequential self-terminating heterogeneous reactions between highly reactive gas-phase precursor species and surface-
The health-promoting effects of fruits and vegetables have been extensively discussed during the past decade since epidemiologic studies have shown relations between increased intake of fruit and vegetables and decreased incidences of several chronic diseases. It has been suggested that antioxidants are a main contributors to the observed effects, for example by acting as scavengers of free radica
In sexual conflicts and conflicts between parents and offspring, natural selection acts in different directions on the two sides. For example, males may be selected to achieve many mates, but female fitness may be maximised by monogamy. In this thesis I study the evolutionary outcome of these situations mainly by theoretical modelling. I present an empirical investigation of mating interactions in
Catecholamines, comprising the neurotransmitters dopamine (DA), noradrenaline (NA) and adrenaline (A) are synthesized by specific enzymes (tyrosine hydroxylase (TH), dopamine ß-hydroxylase (DBH), phenylethanolamine-N-methyltransferase (PNMT)) in the central nervous system. The development and distribution of different catecholaminergic systems have been described in both the brain and retina of th
Phytoplankton growth and loss rates are governed by several factors and in many cases, when growth control fails, algal blooms are established. Such blooms can be formed by different phytoplankton species and some of them have harmful impacts on marine ecosystems. One of these negative impacts by some bloom-forming phytoplankton is the ability to produce toxic or inhibitory compounds with broad ef
The aim of this thesis was to study the function of the integrin a10b1. Integrins mediate signals between cells and their environment and regulate several cellular processes such as cell migration, proliferation and differentiation. The a10b1 integrin is expressed mainly by chondrocytes, the only cell type present in cartilage, and facilitates binding of the chondrocytes to the extracellular matri
The aim of this thesis work is to understand and be able to control polypeptide conformation and interactions at interfaces and in solution by changing the solution conditions. For this purpose simple model polypeptides, so-called polyamino acids, have been investigated at the air-liquid interface, as well as in aqueous solutions. The influence of subphase characteristics, spreading solvent and po
The overall aims of this work were to evaluate a method of assessing postural control, measured by balance in single-limb stance on a force platform, and to study balance in single-limb stance in individuals with non-operated anterior cruciate ligament (ACL) injury in comparison with that of uninjured controls. Ninety-nine patients (99) with ACL injury and 141 uninjured subjects were included in
Alveolar fluid clearance is driven by active absorption of Na+ across the alveolar epithelium. Development and hormonal regulation of alveolar fluid clearance over 1 hour was studied by instillation of a protein-containing, isosmolar fluid into lungs of fetal, newborn, and adult guinea pigs. After 1 hour, a sample of remaining alveolar fluid was collected and the change in protein concentration wa
Non-heme mononuclear iron oxygenases catalyze a large number of oxidation reactions in biological systems. The reactions are often proposed to proceed via the intermediacy of high valent Fe(IV) oxo (ferryl) or, Fe(V) oxo (perferryl) intermediates. Therefore, in order to mimic the high valent Fe(IV) oxo chemistry as well as the catalytic processes exhibited by those enzymes, new functional model co
The aim of this thesis was to identify the influence of calcium, physical activity and detraining on bone mass and bone size in girls and young women. We hypothesised that calcium intake above a specific level does not enhance the accrual of bone mineral, that exercise predominantly influences the skeleton in the early pubertal period and that reduced training is followed by a loss of exercise-ind
Stroke is the most common life-threatening neurological disease and ranks as the third leading cause of death in major industrialized countries. It is also the leading cause of serious long-term disability and about sixty percent of survivors have disabilities in their extremities. Recovery of certain neurological functions occurs over time, which has been attributed to endogenous restorative proc
The Malmö Preventive Project, a preventive, case-finding programme for cardiovascular risk factors and alcohol abuse was created in 1974 at the Department of Preventive Medicine of Malmö University Hospital. Between 1974-1992, a total of 22 444 men (mean age 44 years range 27 - 61) and 10 902 women (mean age 50 years, range 28 - 58) attended the programme, with an overall attendance rate of 70% (r
