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Sustainable development relies on our ability to make decisions today that will determine our tomorrow. Given that uncertainty is explicitly allowed to influence our view of what the future holds for us, most ex ante analyses of challenges for sustainable development can be viewed as analysing risk. Many frameworks for analysing risk exist today, but analysing risk for sustainable development enta
A new energy regime has recently become accessible in collisions at the Large Hadron Collider at CERN. Abundant in hadron collisions, the two-jet final state explores the structure of the constituents of matter and the possible emergence of new forces of nature, in the largest momentum transfer collisions produced. The results from searches for phenomena beyond the Standard Model in the dijet angu
The main scope of this thesis has been to study and develop new purification methods and also to further develop existing methods for purification to enhance their efficacy. Important parameters in the development of the methods are that they should be suitable for scale-up and possible to be integrated into recovery processes. The studies in this thesis describe that a hydrophobic peptide tag ca
In this thesis mechanisms of neuronal damage were investigated in an experimental stroke model i.e focal ischemia. The influence of SD-induced calcium transients on neuronal damage were studied in animals with reduced energy supply. The influence of bioenergetic failure on K+e concentration and Ca2+e homeostasis were also investigated in transient focal ischemia. Moreover, the free radical formati
Background - The effects of intervention can be evaluated in different ways, and objective measurements of changes in lung function are commonly used as the outcome measure. Patient-reported outcome (PRO) is an umbrella term used for all patient-based assessments. One important PRO is health-related quality of life (HRQL), which may be used as an evaluative or discriminative measure. Objectives -
Proteins carry out the instructions encoded in genes and are crucial for many important tasks in the living organism. Often the specific three dimensional structure, or fold, of a protein enables it to carry out a given task. It is an open question whether protein folds have arisen independently or whether mutations to existing protein sequences have caused switches to new folds. In the main part
This thesis deals with different aspects of fatigue crack propagation in IN718. The ultimate objective of the work is to gain understanding of the fatigue process, from the macroscopic stress-strain relations to microscopic fatigue crack growth mechanisms. First, the stress-strain relations, which are fundamental in order to understand what the material encounter, are dealt with. The high temperat
Engagement in daily activities is central for people’s health and well-being. Today, our activity arenas mostly cover great geographical areas, and to reach different activities we must travel. However, people with functional limitations are sometimes restricted in their travelling. In order to investigate accessibility problems in different travel chains, the overarching objective of this thesis
Streptomycetes are Gram-positive bacteria with a complex developmental life cycle. They form spores on specialized cells called aerial hyphae, and this sporulation involves alterations in growth, morphogenesis and cell cycle processes like cell division and chromosome segregation. Understanding the developmental mechanisms that streptomycetes have evolved for regulating for example cell division i
Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are omega-3 fatty acids, which have health promoting effects. Since they are highly prone to oxidation, they should be protected, in particular DHA. Several lipids containing DHA were evaluated with respect to the ability of the lipids to protect DHA against peroxidation using an HPLC method developed as part of this research. Furthermore,
Under Indonesia's authoritarian New Order regime of President Suharto, the role envisaged for the small nationalist-Christian coalition the Indonesian Democratic Party (PDI) was that of a pliant state corporatist party, the existence of which was meant to demonstrate the ostensibly democratic character of the regime. From the second half of the 1980s, however, the party began to develop in a criti
An efficient transfer of energy in molecular systems has proven to be of fundamental importance both in nature and industrial applications. The ability of molecules to work together forming collective excitations, so-called excitons, plays a key role in for example the extraordinary fast energy transfer involved in the first steps of photosynthesis. The characterization of excitonic states in conj
Rheumatoid arthritis (RA) is probably the most common source of treatable disability in the Western world. There are several disease-modifying antirheumatic drugs (DMARDs), which have proven to be of therapeutic efficacy in RA, but the lack of a potent, reliable treatment for early RA is a major problem in modern medicine. An obvious line of approach in the quest for better antirheumatic drugs is
Volatile agents are economically and ecologically acceptable only when administered via low-flow systems. However, sevoflurane degrades during low-flow anaesthesia to compound A, and a high carbon dioxide absorber temperature increases this degradation. This thesis suggests that there is a correlation between apparatus dead-space volume and absorber temperature during low- and minimal-flow sevoflu
The present thesis is concerned with the theoretical study of x-ray photoemission spectra from clean and adsorbate-covered metal surfaces. The main tool is ab initio density functional (DFT) total energy calculations. The first part gives an overview of the theoretical treatment of x-ray photoemission with our present contributions highlighted, and an introduction to DFT theory and computational t
Prostate cancer is one of the major causes of cancer related deaths in men in Europe and the United States. In this doctoral thesis, radioimmunoimaging and -therapy of prostate cancer was investigated pre-clinically by targeting the human kallikrein-related peptidase 2 (hK2) with radiolabelled monoclonal antibodies. hK2 is an antigen that is over-expressed in prostatic neoplasms and is closely rel
Patients suffering from renal failure must remove extracellular water and waste products from their body in order to survive. One way of doing this is by treatment with peritoneal dialysis (PD). During PD treatment the abdominal cavity is filled and drained continuously with one to three liters of dialysis solution, often containing glucose, which act as an osmotic agent. Glucose creates a pressur
The old, world-wide phenomenon of playing board games has received little attention among scholars studying the ancient cultures. This thesis collects and analyses game-related material from Bronze Age Crete, defines the field of research and provides a framework with definitions and typologies. A further goal is to use the results of the analyses to extend beyond the archaeological material and e
Heat processing of vegetables involves the use of temperatures above the physiological limit which affect the cellular structures of the tissue and induce a series of events at cell level that will in turn be reflected in the transport properties of the tissue. One of the most important cellular structures from the mass transport point of view is the cell membrane since it represents the physical
