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We study the spectral phase introduced by parametric amplification and how high extraction efficiency of energy leads to deterioration of the phase. Avoiding this regime, and using a pulse shaper, we achieve high-contrast ultrashort pulses.

Soundscape management in a city implies mitigating harmful sounds and promoting useful ones, according to their environmental, social or cultural significance and considering a more human centered paradigm. The Soundscape approach does not consider sound as a waste but a resource and its application may reach more benefits than solely noise control actions. This conception conveys an emerging para

The requirements on increasing functionality, quality, and, customisation, while reducing cost has lead to the introduction of an architecture centred development process for electronic systems at Volvo Cars. This process enables better control of system integration and achieving non-functional requirements, such as reusability, understandability, etc. The result of the process is a reference arch

Broar över vattendrag utgör viktiga element i många transportsystem. Om broar kollapsar orsakas betydande problem med både direkta och indirekta kostnader för samhällsekonomin. Lokal erosion av botten kring broar är många gånger en huvudorsak till brokollaps, ofta i samband med extrema flödessituationer. Risken för sådan lokal erosion kan bli större i samband med en framtida klimatförBridges are important components in many transportation networks often spanning rivers and other water bodies. The failure of a bridge will cause significant direct and indirect economic losses to society. Scouring of the river bed around bridges is a principal mode of bridge failure typically associated with large floods. The risk of such scour may become higher with the emerging climate chang

BACKGROUND: Pramipexole, a dopamine agonist, has demonstrated antidepressant efficacy as an augmentation strategy in unipolar and bipolar depression. However, dopaminergic treatments are associated with impulse control disorders, including gambling disorder, and evidence regarding behavioural risks in psychiatric populations remains limited.METHODS: We conducted a nationwide register-based cohort

Introduction: Opioid maintenance treatment is the dominant treatment for treating opioid dependence. The treatment is individualised and combines pharmaceuticals with psychosocial support. Aim: This study aimed to increase the understanding of the pathway to recovery, by illustrating the life course of patients within OMT before and after starting treatment using time-geographic life charts. Metho

Background In adults with serious respiratory illness, breathlessness is prevalent and associated with reduced health-related quality of life. The aim of this review was to assess the impact of breathing techniques on breathlessness in adults with serious respiratory illness. Methods Electronic databases were searched to identify randomised controlled trials testing breathing techniques (technique

Background: Acute kidney injury (AKI) is a serious complication of out-of-hospital cardiac arrest (OHCA). Post-resuscitation cardiogenic shock (CS) is a key contributing factor. Targeting a higher arterial carbon dioxide tension may affect AKI after OHCA in patients with or without CS. Methods: Pre-planned exploratory study of a multi-national randomised trial comparing targeted mild hypercapnia o

Background: Chronic breathlessness adversely impacts people with chronic obstructive pulmonary disease and their caregivers (family and friends), who may, in turn, experience significant burden due to their caregiving role. Sustained-release morphine may reduce chronic breathlessness in some patients, which may have an impact on caregivers’ perceived burden. Aim: To explore the impact on caregiver

Background: Home oxygen therapy (HOT) improves survival in patients with hypoxaemic chronic respiratory disease. Most patients evaluated for HOT are former or active smokers. Oxygen accelerates combustion and smoking may increase the risk of burn injuries and fire hazards; therefore, it is considered a contraindication for HOT in many countries. However, there is variability in the practices and p

Background: Predicting severe preeclampsia with need for intensive care is challenging. To better predict high-risk pregnancies to prevent adverse outcomes such as eclampsia is still an unmet need worldwide. In this study we aimed to develop a prediction model for severe outcomes using routine biomarkers and clinical characteristics. Methods: We used machine learning models based on data from an i

Introduction: A subgroup of severe Traumatic Brain Injury (TBI) patients, known as ultra-severe (us-TBI), is most commonly defined as a post-resuscitation Glasgow Coma Scale (GCS) of 3–5. There is uncertainty on whether these critically injured patients can benefit from neurosurgical intervention. Research question: The available evidence regarding the decision-making and outcome following managem

Background: Bioactive adrenomedullin (bio-ADM) is a vasoactive peptide with a key role in reducing vascular hyperpermeability and improving endothelial stability during infection, but it also has vasodilatory properties. Bioactive ADM has not been studied in conjunction with acute respiratory distress syndrome (ARDS), but it has recently been shown to correlate with outcomes after severe COVID-19.

A sports-related concussion (SRC) is most commonly sustained in contact sports, and is defined as a mild traumatic brain injury. An exercise-induced elevation of core body temperature is associated with increased brain temperature that may accelerate secondary injury processes following SRC, and exacerbate the brain injury. In a recent pilot study, acute head-neck cooling of 29 concussed ice hocke

One of the characteristics of Polish foreign aid is its focus on the ‘transition experience’ and civil society. This specific celebration of the ‘Polish success story’ contrasts sharply with public debates that frequently criticise the weaknesses of Polish civil society and the difficulties in state – non-state relations. The Polish Aid apparatus itself is not immune to these problems, often exhib

This article provides an insight into the world of Polish development workers operating in South Sudan. It shows that the conceptualisations of aid work in terms of a ‘mission’, a unique job with a special, ethical goal, a difficult, risky operation requiring specific skills are not incidental. Instead, the point is made, that such ways of thinking about foreign aid and distant locations are stron

Background: Previous studies suggest an antidepressant effect of omega-3 fatty acids (n-3 PUFAs). This effect may be larger in patients with low-grade inflammation, defined as mild elevations of high sensitivity C-reactive protein or other commonly used inflammatory markers. The antidepressant mechanisms of n-3 PUFAs are not fully understood but may involve modulation of immunometabolic processes