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Water for Injection (WFI) is a critical utility in pharmaceutical manufacturing, traditionally produced through an energy-intensive distillation process. This thesis investigates the feasibility of a more sustainable alternative, ambient WFI production using membrane-based purification technologies combined with ozonation in the storage and distribution loop. Conducted in collaboration with AstraZ
Aquaporins (AQPs) are a family of transmembrane proteins, mainly mediating water transport over the cell membrane in various parts of the body. The aquaporins AQP3 and AQP7 are both part of the subfamily aquaglyceroporins, which apart from water conduct small non-polar solutes such as glycerol. AQP3 overexpression or malfunction has been connected to skin and lung cancer and potential AQP3 inhibit
Jus cogens norms and obligations erga omnes are concepts within international law that are often used to reinforce legal claims. This thesis aims to assess to what extent invoking these concepts, along with their reinforcing capabilities, is justified in specific cases. In order to achieve this, the thesis first gives an overview of the theoretical debate surrounding the concepts of jus cogens no
Distribution patterns of resources and their role in determining species distribution are not only fundamental to the understanding of ecological patterns, but also of practical significance in conservation management. Shorebirds are experiencing precipitous declines globally, especially along the East Asian-Australasian Flyway (EAAF), where the major threats include the loss and degradation of ti
Islamiska Staten har de senaste fem åren orsakat oerhört mycket smärta och sorg. Krigsförbrytelser, brott mot mänskligheten och folkmord ska ha begåtts i de områden rörelsen kontrollerat i Irak och Syrien. Nu när kalifatets sista fästen besegrats står det internationella samfundet inför en ny utmaning; hur och var ska de ansvariga individerna straffas? Vissa politiker har numera hävdat att en IS-tDuring the past five years, the Islamic State has been responsible for a large amount of pain and suffering. War crimes, crimes against humanity and genocide have been committed in the areas the group controlled in Iraq and Syria. Now as the Kalifate’s last strongholds have been defeated, the international community stands before a new task; how and where shall the individuals responsible be punis
In recent years, an increasing number of ecosystems are threatened by seasonal flooding, changing non-flooded shoreland (NF) into seasonally flooded wetland (SF), but the consequences of this hydrological change for soil organic carbon (SOC) dynamics remain unknown. In this study, we investigated how the SOC content was determined by flooding duration and soil physicochemical variables in adjacent
Over the years, the field of landslide disaster research has amassed a wealth of data and specialized knowledge. However, these resources originate from a wide array of sources and often feature complex data structures, highlighting a persistent lack of methods to integrate multi-source, heterogeneous data. Traditional landslide monitoring methods typically focus on singular monitoring targets and
Accurate monitoring of daily precipitation is essential for many applications, such as simulation and prediction of watershed water-related disasters. However, precipitation data from satellite and gauge-based precipitation products face challenges in capturing true observations because of their large uncertainties. To improve daily precipitation estimates, this study proposed a new merging framew
In recent years, the flash flood occurs frequently and intensively. It has become a world-wide focus in the field of disaster prevention and mitigation. The flash flood critical rainfall determination method, flash floods forecasting model and experience forecasting method are the most commonly used methods. This study focused on the application of hydrological models for flash floods simulation.T
Although climate change and international trade are interdependent, policy-makers often address the two topics separately. This may inhibit progress at the intersection of climate change and trade and could present a serious constraint for global climate action. One key risk is carbon leakage through emission outsourcing, i.e. reductions in emissions in countries with rigorous climate policies bei
OBJECTIVE: To identify ways that provision of hemophilia care can be maximized at the local level, irrespective of available resources or cultural or geographic challenges.METHODS: The SHIELD group used its multinational experience to share examples of local initiatives that have been employed to deliver optimal hemophilia care.RESULTS: The examples were reviewed and categorized into four key them
Soil freezing/thawing is an important mechanism to control soil water and heat redistribution in mid-to-high latitudes. Salt in the agricultural soil from mid-to-high latitudes can alter characteristics of soil freezing/thawing cycle and then affect soil thermal and hydrological processes in winter and finally cause salinization in spring. To quantify the impacts of soil salinization on soil water
Polycentrism has gradually become a newly emergent dimension of global urbanization. Many countries worldwide have tailored plans suited to functional polycentricity, in light of the prevalent “ghost cities” or “empty towns” as lessons from the morphologically polycentric development practices. However, the subject of defining and measuring functional polycentricity is still in an initial developm
Precipitation in arid mountainous areas is characterized by low rainfall intensity and large spatial heterogeneity, which challenges satellite-based monitoring by the spaceborne sensors. This study aims to comparatively evaluate the detection ability of spatiotemporal patterns and extremes of rainfall by a range of mainstream satellite precipitation products [TMPA, Climate Hazards Group Infrared P
Background: Public trust is central to the collection of genomic and health data and the sustainability of genomic research. To merit trust, those involved in collecting and sharing data need to demonstrate they are trustworthy. However, it is unclear what measures are most likely to demonstrate this. Methods: We analyse the ‘Your DNA, Your Say’ online survey of public perspectives on genomic data
Things such as organizations, persons, or locations are ubiquitous in all texts circulating on the internet, particularly in the news, forum posts, and social media. Today, there is more written material than any single person can read through during a typical lifespan. Automatic systems can help us amplify our abilities to find relevant information, where, ideally, a system would learn knowledge
