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Muscarinic acetylcholine receptors (mAChRs) play a central role in the mammalian nervous system. These receptors are G protein-coupled receptors (GPCRs), which are activated by the agonists acetylcholine and muscarine, and blocked by a variety of antagonists. Mammals have five mAChRs (m1-m5). In this study, we cloned two structurally related GPCRs from the fruit fly Drosophila melanogaster, which,
Growth anomaly of trees in some regions was detected under current episode of rapid warming. Thisraises a dilemma for temperature reconstructions by using tree-ring width which is believed to be themost important proxy on inter-annual temperature reconstruction during the past millenniums. Here weemployed the tree-ring d13C to reconstruct temperature variations for exploring their potential oncapt
Climate warming is expected to accelerate glacier retreat and shift hydrological regime, which poses great threat to regional water resources in terms of amount, variability, and quality. This is especially true in arid regions with glaciers such as the Central Asia. However, few models manage to mimic both glacier runoff and surface changes with adequate performance.
Popular Abstract in Swedish De arida och semi-arida grässtäpperna i Norra Kina anses vara svårt drabbade av markförstöring, främst genom vind- och vattenerosion, men även genom försaltning. Den rådande uppfattningen är att markförstöring och ökenspridningsproblematiken har eskalerat sedan införandet av de ekonomiska reformerna efter 1978, bl.a. genom en expansion av den odlade arealen på tidigare
The Triassic-Jurassic (Tr-J) boundary marks a major extinction event, which (similar to 200 Ma) resulted in global extinctions of fauna and flora both in the marine and terrestrial realms. There prevail great challenges in determining the exact location of the terrestrial Tr-J boundary, because of endemism of. : and the scarcity of fossils in terrestrial settings leading to difficulties in linking
The purpose of this thesis has been to analyse the mechanism of the market driving approach carried out by a global organisation with a corporate brand. Market driving is a new organisational approach to strategy that lacks a solid theoretical framework, but constitutes a reality of global firms such as IKEA, The Body Shop, Benetton, Dell, Hennes and Mauritz, Starbucks. In the literature, the mark
Following a brief review of the development of medical ultrasonics from the mid-1930s to the mid-1950s, the collaboration between Edler and Hertz that began in Lund in 1953 is described. Using an industrial ultrasonic flaw detector, they obtained time-varying echoes transcutaneously from within the heart. The first clinical applications of M-mode echocardiography were concerned with the assessment
Goodpasture disease (GP) is defined by the presence of anti-glomerular basement membrane (anti-GBM) antibodies and rapidly progressive glomerulonephritis. Besides anti-GBM, many patients with GP produce anti-neutrophil cytoplasmic antibodies (ANCA). For elucidation of the pathophysiologic significance of ANCA in this setting, epitope and antigen specificity of the anti-GBM antibodies and antigen s
The first authoritative overview of tourism studies published post-COVID-19 The Wiley Blackwell Companion to Tourism remains a definitive reference in this interdisciplinary field. Edited and authored by leading scholars from around the world, this state-of-the-art volume provides a comprehensive critical overview of tourism studies across the social sciences. In-depth yet accessible chapters comb
English is widely recognized as the language of science, and English-language publications (ELPs) are rapidly increasing. It is often assumed that the number of non-ELPs is decreasing. This assumption contributes to the underuse of non-ELPs in conservation science, practice, and policy, especially at the international level. However, the number of conservation articles published in different langu
