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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 193158 hits
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Typhoon Haiyan hit the Philippines on 8th November 2013 destroying more than 1 million houses and affecting mostly the poor. This paper discusses user involvement in housing recovery from a capability perspective. The paper also analyses possibilities for extension of the housing solutions. Based on the Sphere handbook and the theoretical framework, a Model for user involvement in evolutionary hou
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Duodenal perforation is a rare, but potentially life-threatening injury. Multiple etiologies are associated with duodenal perforations such as peptic ulcer disease, iatrogenic causes and trauma. Computed tomography with intravenous and oral contrast is the most valuable imaging technique to identify duodenal perforation. In some cases, surgical exploration may be necessary for diagnosis. Specific
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In this thesis, I address people’s experiences of being born with a body that does not meet the normative definitions of male or female. The situation when sex characteristics develop in ways that do not conform to binary models is referred to as intersex or disorders of sex development (DSD). This research has been done in the context of the 2006 medical consensus statement on intersex/DSD, and i
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We report the construction of the first complete genetic linkage map of the laboratory rat. By testing 1171 simple sequence length polymorphisms (SSLPs), we have identified 432 markers that show polymorphisms between the SHR and BN rat strains and mapped them in a single (SHR × BN) F2 intercross. The loci define 21 large linkage groups corresponding to the 21 rat chromosomes, together with a pair
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(Matrix Presented) A new one-pot procedure for the synthesis of substituted pyrrolidine derivatives with commercially available cyclopropyl ketones, aldehydes, and amines by a metal iodide promoted three-component reaction was developed.
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Because of the limitations and liabilities of current testosterone therapies, non-steroidal tissue-selective androgen receptor modulators may provide a clinically meaningful advance in therapy. Using a functional cell-based assay AC-262536 was identified as a potent and selective AR ligand, with partial agonist activity relative to the natural androgen testosterone. A 2-week chronic study in castr
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According to some accounts, an individual participates in joint intentional cooperative action by virtue of conceiving of him- or herself and other participants as if they were parts of a single agent or body that performs the action. I argue that this notional singularization move fails if they act as if they were parts of a single agent. It can succeed, however, if the participants act as if to
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Data defined software is becoming more and more prevalent, especially with the advent of machine learning and artificial intelligence. With data defined systems come both challenges - to continue to collect and maintain quality data - and opportunities - open innovation by sharing with others. We propose Open Data Collaboration (ODC) to describe pecuniary and non-pecuniary sharing of open data, si
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BACKGROUND: The overall incidence of colorectal carcinoma is declining in Western populations; however, single country series demonstrate an increase in young-onset (<50 years) colorectal carcinoma. OBJECTIVE: The purpose of this study was to determine whether the pattern of increasing incidence of young-onset colorectal carcinoma is consistent across 3 Western populations. DESIGN: This is a popul
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Background: Currently, hand-held gamma cameras are being developed for 99mTc imaging, mainly for sentinel lymph node detection. These cameras offer advantages, such as mobility and ease of access, and may be useful also for other applications such as biokinetic studies in animals or for imaging of small, superficial structures in patients. In this work, the suitability of a CZT-based hand-held cam
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Monarchy was the dominant form of rule in the pre-modern era and it persists in a handful of countries. We propose a unified theoretical explanation for its rise and decline. Specifically, we argue that monarchy offers an efficient solution to the primordial problem of order where societies are large and citizens isolated from each other and hence have difficulty coordinating. Its efficiency is ch
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Several climate oscillations have been reported from the early Holocene superepoch, the best known of which is the Preboreal oscillation (PBO). It is still unclear how the PBO and the number of climate oscillations observed in Greenland ice cores and European terrestrial records are related to one another. This is mainly due to uncertainties in the chronologies of the records. Here, we present new
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Litigation involving individuals and entities whose financial assets have been frozen and whose names have been blacklisted in the fight against terrorism is on the rise around the world. However, the global ‘securitization’ of terrorism has rendered court performance of judicial review and the provision of remedies in these cases more difficult. What the main judicial challenges are, the need to
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Prediction of the service lifetime of concrete structures with respect to chloride ingress involves a number of parameters that are associated with large uncertainties. Hence, full-scale measurements are strongly in demand. This paper begins by summarizing statistical distributions based on measurements taken from the Gimsøystraumen Bridge in Norway. A large number of chloride profiles are availab
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The damping ratio is a key performance measure in systems that can be modelled as networks of masses and springs. We derive a lower bound on this quantity that applies to such networks when the masses are subject to viscous damping. The result allows the size of the damping ratio to be understood as a function of the system parameters. We use this to derive a decentralised criterion which, if sati
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One feature of global change is that biota must respond not to single, but to multiple environmental drivers. By growing a model photosynthetic microbe in environments containing between one and eight different drivers, including changes in CO 2, temperature, and pH, in different combinations, we show that the number as well as the identities of drivers explain shifts in population growth rates. T
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Context: The changes that are taking place with respect to environmental sensitivity are forcing organizations to adopt a new approach to this problem. Implementing sustainability initiatives has become a priority for the social and environmental awareness of organizations that want to stay ahead of the curve. One of the business areas that has, more than others, proven to be a vital asset and a p
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Background The scaphoid is the most commonly fractured carpal bone in adults as well as in children. Previous studies have reported a wide range of fracture incidences. Scaphoid fractures and non-unions in children have been sparsely investigated. Aim To perform a systematic review of the current literature on epidemiology of scaphoid fractures and non-unions in adults and children. Methods An ele
