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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 192439 hits

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The lattice decoder is shown to approach the performance of Maximum-likelihood decoder for MIMO wireless systems with low complexity. A VLSI architecture of the K-best Schnorr-Euchner lattice decoder is proposed in this paper. The architecture is optimized on both algorithm and architecture levels, and supports a dynamic range of SNR [less-than or equal to] 30 dB. Compared to a conventional VLSI i

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“Strategic Energy Solutions” is the final report on energy solutions for a zero emission Öresund region. It consists of numerous solutions that have been, or can be, applied in the region in order to minimise the environmental impact of the energy sector. Additionally it includes a case study of energy transition projects on Lolland Island in Denmark. The report seeks to provide recommendations fo

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This paper presents the study of a mid-sized semi-closed oxy-fuel combustion combined cycle (SCOC-CC) with net power output around 108 MW. The paper describes not only the power balance and the performance of the SCOC-CC, but also the conceptual design of the SCOC turbine and compressor. A model has been built in the commercial heat and mass balance code IPSEpro to estimate the efficiency of semi-

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We have measured production cross sections of projectilelike fragments in the reaction of neutron-deficient 112Sn with a 9Be target at an energy of Elab=1A GeV. Results have been obtained for neutron-deficient products along the N=Z line down to the subnanobarn range. We find very good agreement with the recently revised empirical parametrization EPAX. In addition, a few one- and two-proton pickup

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Members of the TALE (Three-amino acid loop extension) family of atypical homeodomain-containing transcription factors are important downstream effectors of oncogenic fusion proteins involving the mixed lineage leukemia (MLL) gene. A well-characterized member of this protein family is MEIS1, which orchestrates a transcriptional program required for the maintenance of MLL-rearranged acute myeloid le

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Alcohol dependence is a devastating illness affecting a large population, and new pharmacological treatments with good efficacy are greatly needed. One potential candidate is varenicline, a smoking cessation agent with partial agonist action at α4 β2 nicotinic acetylcholine receptors.

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Many species from diverse taxa are known to display synchronous fluctuations across vast geographical ranges. It is often thought that climate factors influencing the growth of conspecific populations are correlated over large distances and hence produce the synchronous population dynamics - an effect known as the Moran effect. However, for species embedded in a food web the Moran effect needs not

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Here we define a function of metastasis-associated protein 1 (MTA1), a presumed corepressor of estrogen receptor alpha (ER alpha), as a transcriptional activator of Breast Cancer Amplified Sequence 3 (BCAS3), a gene amplified and overexpressed in breast cancers. We identified BCAS3 as a MTA1 chromatin target in a functional genomic screen. MTA1 stimulation of BCAS3 transcription required ERa and i

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The wingbeat kinematics and wake structure of a trained house martin in free, steady flight in a wind tunnel have been studied over a range of flight speeds, and compared and contrasted with similar measurements for a thrush nightingale and a pair of robins. The house martin has a higher aspect ratio (more slender) wing, and is a more obviously agile and aerobatic flyer, catching insects on the wi

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This conceptual paper investigates the way in which some Swiss watch firms respond to innovativeness, their capacity to innovate, and their engagement in the innovation process. A purposeful (judgmental) stratified sampling method was employed, where in-depth interviews with thirteen marketing managers and owners, was carried out over a three-month period. Meaning units (MUs) were abstracted, to c

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Objective. To analyze the Immoral immune response to Ro/SSA and La/SSB antigens in detail, in order to identify markers in mothers at high risk of having children with congenital heart block (CHB). Methods. Serum samples were obtained from 9 Ro/La-positive mothers who gave birth to affected children, from their 8 newborns with CHB, and from 26 Ro/La-positive mothers whose children were healthy. An

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A method is described for the assay of lipoprotein lipase, using a stable, radioactive substrate emulsion. Fatty acid-labeled trioleoylglycerol was emulsified by homogenization in glycerol with lecithin as detergent. This anhydrous emulsion was stable for at least six weeks. Substrate solutions for enzyme assay were prepared by diluting the emulsion with buffer containing serum and albumin. The fa