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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 194507 hits

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The abundance of refractory elements in giant planets can provide key insights into their formation histories1. Owing to the low temperatures of the Solar System giants, refractory elements condense below the cloud deck, limiting sensing capabilities to only highly volatile elements2. Recently, ultra-hot giant exoplanets have allowed for some refractory elements to be measured, showing abundances

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The growing popularity of nature-based tourism means that the tourism industry is increasingly utilizing wilderness areas to provide visitor experiences. However, tourism activities negatively impact wilderness quality. Tourism service providers play an important role in shaping these impacts. Therefore, this study investigates their preferences regarding wilderness use and development. It focuses

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Successful implementation of plasma-assisted combustion in applied thermal processes heavily relies on how the plasma can be formed as it interacts with the reactive flow and what the effects are of such a plasma on the combustion process. The current study is an experimental investigation of a plasma-assisted lifted flat methane–air flame by a nanosecond pulsed discharge at atmospheric pressure.

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Resting-state fMRI has proven to entail subject-specific signatures that can serve as a fingerprint to identify individuals. Conventional methods are based on building a connectivity matrix based on correlation between the average time course of pairs of brain regions. This approach, first, disregards the exquisite spatial detail manifested by fMRI due to working on average regional activities, se

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On the basis of the dual variational formulation of a class of elliptic variational inequalities, a constitutive relation error is defined for the variational inequalities as an a posteriori error estimator, which is shown to guarantee strict upper bounds of the global energy-norm errors of kinematically admissible solutions. A numerical example is presented to validate the strictly bounding prope

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The processes responsible for methane (CH4) emissions from boreal wetlands are complex; hence, their model representation is complicated by a large number of parameters and parameter uncertainties. The arctic-enabled dynamic global vegetation model LPJ-GUESS (Lund-Potsdam-Jena General Ecosystem Simulator) is one such model that allows quantification and understanding of the natural wetland CH4 flu

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Context. Super-Earths and mini-Neptunes are missing from our Solar System, yet they appear to be the most abundant planetary types in our Galaxy. A detailed characterization of key planets within this population is important for understanding the formation mechanisms of rocky and gas giant planets and the diversity of planetary interior structures. Aims. In 2019, NASA’s TESS satellite found a tran

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Non-ordinary states of consciousness (NOC) offer a way to examine how large-scale brain dynamics reorganize as experience changes. We studied a participant able to reliably enter a self-induced NOC state characterized by vivid imagery, altered bodily perception, and a sense of unity. Across 20 fMRI sessions, we measured functional connectivity in four conditions (Baseline, Transition, NOC, and Res

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We extend the generalized information criteria framework for model selection to high-dimensional sparse statistical jump models, a recent class of statistically robust and computationally efficient alternatives to hidden Markov models. Specifically, we derive expressions for the model fit and complexity to construct suitable information criteria for hyperparameter selection. In extensive simulatio

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Co-design processes are of key importance in planning and implementing Nature-based Solutions (NBS), but require boundary management between diverse holders of local, practical and scientific knowledge. Participatory and mapbased planning tools, such as Geodesign workshops, can facilitate such boundary management through mobilising knowledge holders, and translating and negotiating between differe

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For analytic operator functions, we prove accumulation of branches of complex eigenvalues to the essential spectrum. Moreover, we show minimality and completeness of the corresponding system of eigenvectors and associated vectors. These results are used to prove sufficient conditions for eigenvalue accumulation to the poles and to infinity of rational operator functions. Finally, an application of

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The recent rise in atmospheric methane (CH4) concentrations accelerates climate change and offsets mitigation efforts. Although wetlands are the largest natural CH4 source, estimates of global wetland CH4 emissions vary widely among approaches taken by bottom-up (BU) process-based biogeochemical models and top-down (TD) atmospheric inversion methods. Here, we integrate in situ measurements, multi-

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In this paper, we show that a software implementation of IND-CCA-secure Saber key encapsulation mechanism protected by first-order masking and shuffling can be broken by deep learning-based power analysis. Using an ensemble of deep neural networks trained at the profiling stage, we can recover the session key and the secret key from 257 × N and 24 × 257 × N traces, respectively, where N is the num

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This paper is concerned with analysing the growing role of the International Federation of Accountants (IFAC) in governing the world of auditing. Whereas the setting of standards for auditing has previously been the task of national authorities, that responsibility has now been passed to a large degree to IFAC, as the meta-organisational body for professional associations of accountants around the

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Methylenetetrahydrofolate reductase (MTHFR) protein catalyzes the only biochemical reaction which produces methyltetrahydrofolate, the active form of folic acid essential for several molecular functions. The Ala222Val polymorphism of human MTHFR encodes a thermolabile protein associated with increased risk of neural tube defects and cardiovascular disease. Experimental studies have shown that the

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Autoimmune liver diseases (AiLDs), including autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC), are immune-mediated conditions associated with significant hepatic and systemic manifestations. Among these, cytopenias-defined as reductions in blood cell counts affecting single or multiple lineages-represent a clinically important, though often un

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PrologMikrovågs-hypertermi och strålbehandling (1980–1990)Min tidiga forskning inom medicinsk strålningsfysik ledde till kombinerad behandling av bröstcancer-recidiv med mikrovågsinducerad hypertermi och lågdos strålning (30 Gy). Kliniska försök inleddes med patienter som tidigare fått full stråldos (60 Gy). Utrustningen visades upp för kung Carl XVI Gustaf och drottning Silvia på Forskningens DagThis story has its origin in my presentation at the 1983 Research Day in Lund, to HM King XIV Gustav on our development of microwave-induced hyperthermia treatment of breast cancer recurrence, which brought me together with Professor Leif G. Salford, whose presentation was next to mine. Shortly before the turn of the millennium, Leif Salford initiated a clinical trial "Brain Immune Gene Tumour

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Popular Abstract in Swedish Akut öroninflammation är vanligt hos barn och många barn får sin första öroninflammation redan vid tidig ålder. Öronbarn kallas de barn som drabbas av upprepade öroninflammationer. Dessa barn drabbas oftare än andra barn också av andra infektioner. Flera undersökningar har utförts tidigare för att kartlägga olika riskfaktorer. Undersökningarna har visat varierande resulAcute otitis media (AOM) is a common complication after episodes of respiratory tract infections in childhood. Some children have recurrent episodes and they are often called otitis-prone. These children are prone not only to middle-ear diseases but also to other infectious diseases. The aims of the present study of otitis-prone children and controls were to describe the overall illness and need f