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CYLD is a tumour-suppressor gene that is mutated in a benign skin tumour syndrome called cylindromatosis. The CYLD gene product is a deubiquitinating enzyme that was shown to regulate cell proliferation, cell survival and inflammatory responses, mainly through inhibiting NF-kappa B signalling. Here we show that CYLD controls cell growth and division at the G(1)/S-phase as well as cytokinesis by as

A Holocene sediment sequence from Lake Seukokjaure, a subarctic lake at tree-line in northern Sweden, was analyzed to assess major changes in the structure and functioning of the aquatic ecosystem in response to climate change and tree-line dynamics. The compiled multi-proxy data, including sedimentary pigments, diatoms, chironomids, pollen, biogenic silica (BSi), carbon (C), nitrogen (N) elementa

In this work we have calculated U from first principles for the early lanthanides (Ce-Gd) using the constrained random phase approximation (cRPA). We compare the static limit of U with experimental estimations from x-ray photoemission spectroscopy (XPS) and bremsstrahlung isochromat spectroscopy (BIS) spectra and also discuss the frequency dependence of U across the series. The localized subspace

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Recent research has brought into focus the function of switching between verb forms and types of clauses, here labelled ‘gram switching’, as a device for marking non-main clause linking in various types of Arabic and in Biblical Hebrew (Persson forthcoming a; Isaksson, Kammensjö, and Persson 2009; Isaksson 2011, 2013). The study presented here shows that a switch, either in verb form/morphology or

BACKGROUND: In Saccharomyces cerevisiae galactose is initially metabolized through the Leloir pathway after which glucose 6-phosphate enters glycolysis. Galactose is controlled both by glucose repression and by galactose induction. The gene PGM2 encodes the last enzyme of the Leloir pathway, phosphoglucomutase 2 (Pgm2p), which catalyses the reversible conversion of glucose 1-phosphate to glucose 6

Hälsoeffekter av näringsämnen har traditionellt undersökts genom att analysera en eller ett fåtal fysiologiska markörer, exempelvis blodkolesterolnivå. Med nutrigenomik blir det möjligt att ta ett större grepp om hur kosten påverkar vår hälsa och även koppla det till individens genuppsättning.

Popular Abstract in Swedish Arbetsplatsens positiva sidor kan förbättras genom ett nytt dialogverktyg! Nu går det att mäta medarbetares positiva upplevelser av arbete. Vanligtvis kopplas människors upplevelser av arbete samman med stress och ohälsa. Men det går att tänka tvärtom, att istället fokusera på allt det positiva som arbete kan ge. När människor mår bra av sitt arbete, blir de också mer The aim of this thesis was to develop and make a quality assessment of a tool, which includes a questionnaire and a dialogue process that could be useful for workplace health promotion from a salutogenic point of view. The studies have been performed within two health care organizations between 2005 and 2009, together with hospital staff. Two questionnaire studies were conducted (n=446 n=505, resp

Background: Improvement of the process of cellulase production and development of more efficient lignocellulose-degrading enzymes are necessary in order to reduce the cost of enzymes required in the biomass-to-bioethanol process. Results: Lignocellulolytic enzyme complexes were produced by the mutant Trichoderma atroviride TUB F-1663 on three different steam-pretreated lignocellulosic substrates,

This article analyzes the effectiveness of transnational multi-stakeholder partnerships for sustainable development-also known as "Type II outcomes" of the 2002 World Summit on Sustainable Development-in the sustainable energy sector. We combine quantitative and qualitative research. Quantitatively, we use a database of 340 partnerships, including 46 partnerships that focus on energy. Our qualitat

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Why in a barren and hot desert, clays can contain a significant fraction of water? Why does concrete crack? How can we demonstrate that complexation of a drug does not alter its conformation in a way that affects its functionality? In this paper we present results on various studies using Quasi-Elastic Neutron Scattering aimed at clarifying these questions. To allow for a better understanding of n

The aim of this study was to evaluate whether primary osteoarthritis (OA), independent of affected joint, is associated with a phenotype that is different from the phenotype in a normative cohort. Material and.

Systemic glucose homeostasis is profoundly influenced by adipose cell function. Here we investigated GLUT4 dynamics in living adipose cells from human subjects with varying BMI and insulin sensitivity index (S-i) values. Cells were transfected with hemagglutinin (HA)-GLUT4-green fluorescent protein (GFP)/mCherry (red fluorescence), and were imaged live using total internal reflection fluorescence

OBJECTIVE: To estimate the association between the appearance of cesarean hysterotomy scars at transvaginal ultrasound examination of nonpregnant women and the outcome of subsequent pregnancies and deliveries. METHODS: A total of 162 women who had ever given birth by cesarean underwent transvaginal ultrasound examination of the hysterotomy scar 6 to 9 months after the latest cesarean delivery. Pub

A three-dimensional CFD numerical simulation is successfully carried out on thermo-hydraulic characteristics of a new smooth wavy fin-and-elliptical tube (SWFET) heat exchanger with three new types of vortex generators (VGs), namely - rectangular trapezoidal winglet (RTW), angle rectangular winglet (ARW) and curved angle rectangular winglet (CARW). Several parameters have been examined in this stu