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Protein chips based on recombinant antibody fragments: A highly sensitive approach as detected by mass spectrometry

With the human genome in a first sequence draft and several other genomes being finished this year, the existing information gap between genomics and proteomics is becoming increasingly evident. The analysis of the proteome is, however, much more complicated because the synthesis and structural requirements of functional proteins are different from the easily handled oligonucleotides for which a f

Drug targeting to the brain: Transfer of picolinic acid along the olfactory pathways

Picolinic acid (PA) protects against quinolinic acid- and kainic acid-induced neurotoxicity in the brain. To study the uptake of PA to the brain, we administered [H-3]PA via a unilateral nasal instillation or iv injection to mice. Autoradiography demonstrated a rapid uptake of radioactivity in the olfactory nerve layer and in the ipsilateral olfactory bulb (OB) following nasal instillation of [H-3

Isoscalar dipole strength in Pb-208(82)126: The spurious mode and the strength in the continuum

The isoscalar dipole (compression) mode is studied first using the schematic harmonic-oscillator model, and then the self-consistent Hartree-Fock (HF) and random-phase approximation (RPA) are solved in coordinate space. Taking Pb-208 and the SkyM* interaction as a numerical example, the spurious component and the strength in the continuum are carefully examined using the sum rules. It is pointed o

Truck Model for Yaw Dynamics Control

This report describes the derivation of a nonlinear model of a tractor-semitrailer combination vehicle. The purpose of the model is validation of yaw-control algorithms. The model include 4 DOF in lateral, longitudinal, and yaw motion. It is formulated as a state-spece model with 5 state variables. Additional states are added with the rotational dynamics of the wheels. The model includes a static

Scoring systems for grading deep leg vein thrombosis.

A scoring system could be used in all situations where grading of deep leg vein thrombosis (DVT), including mapping of its distribution, is needed. It should also be used in epidemiological studies of DVT in further analysis of different risk groups suffering from DVT. Several scoring systems have been developed during the last three decades but have resulted in various complex and impractical sys

Passenger assessments of quality in local public transport- measurement, variability and planning implications

Popular Abstract in Swedish Resenärernas värderingar av kvalitet i lokal kollektivtrafik – hur man kan mäta dem, hur de varierar och hur man kan använda dem i planeringen Syftet med arbetet har varit att ta fram ett mer detaljerat underlag för planering av lokal kollektivtrafik. Med mer kunskap om hur olika grupper av resenärer värderar olika delar av en kollektivtrafikresa kan kollektivtrafiknätThe aim of this work was to get a more detailed basis for planning of local public transport. With more knowledge of how segments of travellers assess different parts of a journey, bus routes can be planned to fit either all passengers or selected groups better. It will also be possible to evaluate perceived travel utility separately for each category of passengers. Stated Preference questionnaire

Effects of acetabular resurfacing component material and fixation on the strain distribution in the pelvis

A 3D finite element (FE) model of an implanted pelvis was developed as part of a project investigating an all-polymer hip resurfacing design. The model was used to compare this novel design with a metal-on-metal design in current use and a metal-on-polymer design typical of early resurfacing implants. The model included forces representing the actions of 22 muscles as well as variable cancellous b

Transferability of tag SNPs in genetic association studies in multiple populations

A general question for linkage disequilibrium-based association studies is how power to detect an association is compromised when tag SNPs are chosen from data in one population sample and then deployed in another sample. Specifically, it is important to know how well tags picked from the HapMap DNA samples capture the variation in other samples. To address this, we collected dense data uniformly

Bronchoscopic diagnosis of pulmonary infections in a heterogeneous, nonselected group of patients

Fiberoptic bronchoscopy with bronchoalveolar lavage and protected specimen brush technique has become an established method for etiologic diagnosis in severe forms of pulmonary infections during recent years. In this study, including 62 bronchoscopies in 53 patients, a standardized program, covering all important pulmonary pathogens, has been evaluated in a heterogeneous group of patients. Results