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Simulation of near-infrared light propagation through the thorax of a neonate : Addressing the optimisation of source and detector positions for measuring lung oxygen content in preterm infants

Gas in scattering media absorption spectroscopy shortly called GASMAS, is a tunable diode laser spectroscopic technique developed for the measurement of gas present in turbid media. The technique relies on the sharp and specific absorption lines of gases which enables sensitive measurements of gas concentrations in the presence of a scattering solid medium with much broader absorption features. Th

Mitigation of ground vibrations by circular arrays of rigid blocks

Pile driving and other activities in the built environment cause ground vibration at low frequencies. This may result in annoyance to people as well as damage to civil structures. It is known that masses added on the ground surface can have an impact on the vibration levels in the surrounding environment. Hence, employing a semi-analytical model for rigid blocks on the surface of a layered ground,

Benefit from extended surveillance interval on colorectal cancer risk in Lynch syndrome

Aim: Although patients with Lynch syndrome have an increased risk of developing colorectal cancer, surveillance can reduce morbidity and mortality. Whether or not affected individuals benefit from lifetime surveillance depends on individual factors and patient adherence, and these may vary, complicating risk modelling. The aim of this study was to identify individual factors which influence patien

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The essay is an attempt to distinguish between the semantic notion of "childfree" and that of "voluntary childlessness" taking into account the Russian specifics. The author consistently describes socio-political content of the Russian research field emphasizing the conservative pro-natal trends of the recent years. The paper considers the origins of the conceptual field of non-parenthood and the

Reduced order modeling for the dynamic analysis of structures with nonlinear interfaces

In the present paper, linear substructures with nonlinearities localized at their interfaces, such as the joints in a beam structure, are studied. By subdivision of the total structure into substructures, reduced subsystems are obtained by component mode synthesis. Nonlinear elements are introduced at supports or between substructures. A numerical example is presented where a beam subjected to bla

Standardisation of nailfold capillaroscopy for the assessment of patients with Raynaud's phenomenon and systemic sclerosis

Capillaroscopy is a non-invasive and safe tool which allows the evaluation of the morphology of the microcirculation. Since its recent incorporation in the 2013 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for systemic sclerosis together with its assessed role to monitor disease progression, capillaroscopy became a ‘mainstream’ investiga

Inflammatory potential of the diet and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study

Proinflammatory diets are associated with risk of developing colorectal cancer (CRC), however, inconsistencies exist in subsite- and sex-specific associations. The relationship between CRC and combined lifestyle-related factors that contribute toward a low-grade inflammatory profile has not yet been explored. We examined the association between the dietary inflammatory potential and an inflammator

Minimal relapse risk and early normalization of survival for patients with Burkitt lymphoma treated with intensive immunochemotherapy : an international study of 264 real-world patients

Non-endemic Burkitt lymphoma (BL) is a rare germinal centre B-cell-derived malignancy with the genetic hallmark of MYC gene translocation and with rapid tumour growth as a distinct clinical feature. To investigate treatment outcomes, loss of lifetime and relapse risk in adult BL patients treated with intensive immunochemotherapy, retrospective clinic-based and population-based lymphoma registries

'Famous from all antiquity' : Etna in Classical Myth and Romantic Poetry

In the early eighteenth century, the Sicilian volcano Etna was still primarily familiar to European culture through its many classical associations. This chapter examines the interaction between classical accounts of Etna and other, developing genres of describing and representing that mountain in the writings of some famous eighteenth-century travelers and ‘natural philosophers’. In paving the wa

NTRK fusions in osteosarcoma are rare and non-functional events

Neurotrophic tyrosine receptor kinase (NTRK) fusions are promising molecular targets that have been described in a broad range of malignant tumours. Fusions commonly lead to the expression of chimeric proteins with constitutive tyrosine kinase activation that drives tumorigenesis. Despite a low prevalence among most solid tumours (<1%), the first encouraging results with pan-NTRK tyrosine kinase i

Profiling the Protein Targets of Unmodified Bio-Active Molecules with Drug Affinity Responsive Target Stability and Liquid Chromatography/Tandem Mass Spectrometry

Identifying the target proteins of bioactive small molecules is a key step in understanding mode-of-action of the drug and addressing the underlying mechanisms responsible for a particular phenotype. Proteomics has been successfully used to elucidate the target protein profiles of unmodified and ligand-modified bioactive small molecules. In the latter approach, compounds can be modified via click

Radiographers' Experience of Work Performance After Attending a Postgraduate Course in Appendicular Reporting—A Qualitative Study

The radiography profession in Sweden is young but has been rapidly changing over the recent years. The developing profession has led to radiographers facing various challenges related to responsibility for both the technical equipment and patient care in the periradiographic process. Further education is urgent to keep up with the arising level of competence required. The study aimed to explore ra