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Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs. Leveraging phased haplotypes from the 1000 Genomes Project, we report a GWAS meta-analysis of similar to 185,000 CAD cases and controls, interrogating 6.7 million common (minor allele frequency (MAF) > 0.05) and 2.7 million low-fre
Background: When scaling up lignocellulose-based ethanol production, the desire to increase the final ethanol titer after fermentation can introduce problems. A high concentration of water-insoluble solids (WIS) is needed in the enzymatic hydrolysis step, resulting in increased viscosity, which can cause mass and heat transfer problems because of poor mixing of the material. In the present study,
Discrete Time Markov Chains (DTMCs) and Con- tinuous Time Markov Chains (CTMCs) are often used to model various types of phenomena, such as, for example, the behavior of software products. In that case, Markov chains are widely used to describe possible time-varying behavior of “self-adaptive” software systems, where the transition from one state to another represents alternative choices at the so
Waste electrical and electronic equipment (WEEE) has caused concern from many sectors of society due to its growing quantity and potential toxicity. The situation is particularly worrisome in some non-OECD countries, such as India and China, where acute health and environmental hazards have resulted from a combination of a lack of proper WEEE management systems and the domination of a large backya
Susan Petrilli discusses Victoria Welby (1837–1912) and the Signific movement in her book Signifying and Understanding. The disposition of the book is chronological and thematic, and Petrilli’s discussion connects Welby’s work with contemporary semiotics, as well as with the intellectual and scientific landscape of Welby’s own time. For instance, a selection of Welby’s vast correspondence with int
Typically, a significant fraction of phosphorus in soils is composed of organic phosphates, and this fraction thus plays an important role in the global phosphorus cycle. Here we have studied adsorption of monomethyl phosphate (MMP) to goethite (alpha-FeOOH) as a model system in order to better understand the mechanisms behind adsorption of organic phosphates to soil minerals, and how adsorption a
Global positioning system and time-depth recorders were deployed in combination to investigate the foraging behaviour of common murres Uria aalge breeding at Stora Karlsö Island, Baltic Sea, during the chick-rearing period. In the pre-breeding period the main prey species of murres, sprat Sprattus sprattus, is targeted by commercial fisheries, likely reducing prey availability during the breeding
The paper investigates further an approach to modeling dynamically changing Gaussian spatio-temporal fields. In that approach, the dynamics are introduced by embedding deterministic velocities into a stochastic spatio-temporal Gaussian model. In this way, a dynamically inactive stochastic field with given spatial and temporal covariance structure gains dynamics that in general follow a determinist
Members of the TALE (Three-amino acid loop extension) family of atypical homeodomain-containing transcription factors are important downstream effectors of oncogenic fusion proteins involving the mixed lineage leukemia (MLL) gene. A well-characterized member of this protein family is MEIS1, which orchestrates a transcriptional program required for the maintenance of MLL-rearranged acute myeloid le
Differences in survivorship of non-posterior-stabilized compared with posterior-stabilized knee designs carry substantial economic consequences, especially with limited health-care resources. However, these comparisons have often been made between relatively small groups of patients, often with short-term follow-up, with only small differences demonstrated between the groups. The goal of this stud
Radio links in wireless mesh networks (WMN) can select one of several modulation and coding schemes (MCS). A MCS assignment influences links data rates and their mutual interference, and therefore should be optimized. We consider joint optimization of link rate assignment and transmission scheduling in order to maximize the minimal flow in a WMN. One of the main difficulties stems from the require
The dinuclear complex [Zn2(DPCPMP)(pivalate)](ClO4), where DPCPMP is the new unsymmetrical ligand [2-(N-(3-((bis((pyridin-2-yl)methyl)amino)methyl)-2-hydroxy-5-methylbenzyl)-N-((pyridin-2-yl)methyl)amino)acetic acid], has been synthesized and characterized. The complex is a functional model for zinc phosphoesterases with dinuclear active sites. The hydrolytic efficacy of the complex has been inves
Engineers face challenges when they are to manage project groups and be leaders for organisations because such positions demand skills in social competence and empathy. Previous studies have shown that engineers have low degrees of social competence skills. In this study, the level of empathy as measured by the four subscales of the Interpersonal Reactivity Index, perspective taking, fantasy, empa
Removal of five acidic pharmaceuticals (ibuprofen, ketoprofen, naproxen, diclofenac and clofibric acid) by activated sludge from five municipal activated sludge treatment processes, with various sludge ages and nitrification capacities, was assessed through batch experiments. The increase in aerobic sludge age from 1-3 to 7 d seemed to be critical for the removal of naproxen and ketoprofen, with m
Delayed ischemic neurological deficits (DINDs) are a major contributing factor for poor outcome in patients with subarachnoid hemorrhage. In this trial, we investigated the therapeutic potential of prostacyclin, an endogen substance with known effect on vascular tone and blood flow regulation, on factors related to DIND.
The first part of the article examines some recent studies on the early development of social norms that examine young children’s understanding of codified rule games. It is argued that the constitutive rules than define the games cannot be identified with social norms and therefore the studies provide limited evidence about socio-normative development. The second part reviews data on children’s p
Robot-assisted surgery is a technically feasible alternative to open and laparoscopic surgery, which is being more frequently used in general surgery. We undertook this review to investigate whether robotic assistance provides a significant benefit for oesophagogastric cancer surgery.
