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Sum-weighted casein micelle AF4-UV-SAXS data disentangled - A new method for characterization and evaluation of widely size distributed samples

Casein micelles are key structures in milk, influencing stability, nutritional properties, and functionality. Their hierarchical architecture, which is dynamic and responsive to environmental conditions, plays a crucial role in dairy processing. Understanding the structural and dynamic properties of casein micelles is essential for optimizing dairy products and processing techniques. This study pr

A genome-wide association study of imaging-defined atherosclerosis

Imaging-defined atherosclerosis represents an intermediate phenotype of atherosclerotic cardiovascular disease (ASCVD). Genome-wide association studies (GWAS) on directly measured coronary plaques using coronary computed tomography angiography (CCTA) are scarce. In the so far largest population-based cohort with CCTA data, we performed a GWAS on coronary plaque burden as determined by the segment

Risk of recurrence following transanal endoscopic microsurgery without neoadjuvant or adjuvant treatment in T2 rectal cancer

Background: Transanal endoscopic microsurgery (TEM) is only curative treatment for T1 rectal cancer with low-risk features. In T2 cancer, TEM is not recommended but could be used as a palliative procedure and/or in patients unfit for surgery. Few studies exist investigating recurrence after TEM for T2 rectal cancer. Method: Retrospective, population-based study using the Swedish Colorectal Cancer

Association of Circulating Inflammatory Biomarker Levels and Toxicity in Patients Undergoing Pelvic Radiation for Cancer : A Critical Review

Purpose: Radiation therapy (RT) causes tissue damage and inflammation. Because cytokines play a key role in such processes, their expression levels can be an indicator of cell and tissue toxicity. This critical review aims to explore whether levels of circulating inflammatory biomarkers in peripheral blood are associated with proton- or photon-based therapy in the pelvic area and how these levels

HELicobacter Pylori screening to prevent gastrointestinal bleeding in patients with acute Myocardial Infarction (HELP-MI SWEDEHEART) - Design and rationale of a cluster randomized, crossover, registry-based clinical trial

Background: The role of Helicobacter pylori (H. pylori) screening and eradication on reducing upper gastrointestinal bleeding (UGIB) complications after acute myocardial infarction (MI) is uncertain. The HELicobacter pylori screening to prevent gastrointestinal bleeding in patients with acute MI (HELP-MI SWEDEHEART) trial aims to determine whether systematic H. pylori screening compared to usual c

How do root exudates prime the decomposition of soil organic matter following drought?

When dry soil is rewetted, contrasting microbial responses can be induced, ranging from a more resilient type of response with faster growth recovery to a more sensitive type of response with a slower growth recovery. These microbial responses will also affect soil carbon (C) cycling in the rhizosphere. However, whether the microbially-controlled priming of soil organic matter (SOM) mineralization

Navigating the Turbulent Waters of Liability : Making the Case for the Application of Risk-Management-Based Liability Approach to Autonomous Vessels

This chapter is an effort to explore the challenges related to establishing civil liability for independent activities for Maritime Autonomous Surface Ships (MASS) and discusses how these challenges can be addressed in a manner that maintains the balance of interests implied by existing legal mechanisms. The chapter concludes that existing legal mechanisms are insufficient. They fail to recognise

Urine-normetanephrine, a predictor of mortality risk in patients with adrenal adenomas

Urine-metanephrines are used in the screening for pheochromocytomas in patients with adrenal incidentalomas, but their potential as markers for mortality in patients with adrenal adenomas has not been studied. A retrospective cohort study was designed to investigate if urine-metanephrines were associated with mortality in patients with adrenal adenomas. Participants where consecutively included be

Synthetic versus real : an analysis of critical scenarios for autonomous vehicle testing

With the emergence of autonomous vehicles comes the requirement of adequate and rigorous testing, particularly in critical scenarios that are both challenging and potentially hazardous. Generating synthetic simulation-based critical scenarios for testing autonomous vehicles has therefore received considerable interest, yet it is unclear how such scenarios relate to the actual crash or near-crash s

Associations between knee pain and knee-loading physical activities at work and leisure – a cross-sectional study based on accelerometer measurements

Background: Knee pain is often an early sign of knee osteoarthritis (KOA). Physical activities (PA) constitute the recommended regime to those affected. However, knee-loading PA at work is linked to an increased risk for KOA. The primary aim of this study was to investigate associations between knee pain and accelerometer-measured knee-loading PA, at work and leisure respectively. The secondary ai

Therapeutic S100A8/A9 inhibition reduces NADPH oxidase expression, reactive oxygen species production and NLRP3 inflammasome priming in the ischemic myocardium

Oxidative stress and alterations in redox signalling have been implicated in the pathophysiology of myocardial infarction (MI). NADPH oxidase (Nox) is an important source of reactive oxygen species (ROS) in the infarcted myocardium. Alarmin S100A8/A9 amplifies acute myocardial inflammation in MI and has been shown to be a promising therapeutic target to improve cardiac function post-MI. We aimed t

Serum concentrations of per- and poly-fluoroalkyl substances (PFAS) in Danish pregnant women—temporal trends during pregnancy, correlations with partners, associations with physical activity, and blood lipid concentrations

Background: Per- and polyflouralkyl substances (PFAS) are a group of persistent chemicals used extensively in industries and consumer products due to their water-repellent properties. Studies have linked PFAS exposure to adverse health effects, and human exposure to PFAS, especially during pregnancy, is of great concern. In this study, we report how serum PFAS concentrations during pregnancy corre

WUI-NITY 4 : An Industry-Ready WUI Fire Evacuation Model

In recent years, WUI fire evacuation models have started to be developed. Several now exist, although they are primarily research tools unable to be applied in practice or commercially available tools with limited functionality. For this step – moving from research to practice – such models need to build their credibility through data for their development, testing and application. The WUI-NITY to

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Open-pit coal mine reconstructed ecosystems are ecologically fragile. Retained early stage topsoil is usually not enough to maintain plant growth. For this purpose, we used root exudates to fertilize the reconstructed soil and improve the functioning of the soil microorganism ecology. The roots’ exudates increased the concentration of organic matter and total nitrogen by 16–39%. Within a certain c

Journal Digital Corpus : Swedish Newsreel Transcriptions

The Journal Digital Corpus (JDC) is a corpus comprising transcriptions of Swedish historical newsreels, primarily sourced from the SF Veckorevy newsreels produced between the early 1910s and the 1960s. JDC includes transcribed speech from 2,553 newsreels (over two million words) and intertitles from 4,333 videos. Utilizing custom-built Python libraries, SweScribe and stum, the corpus facilitates u

Disparities in the organisation of national healthcare systems for treatment of patients with psoriatic arthritis and axial spondyloarthritis across Europe

Background: Studies on national policies for biologics are warranted. Objectives: To map and compare national healthcare set-ups for prescription, start, switch, tapering, and discontinuation of biologic/targeted synthetic disease-modifying antirheumatic drugs (DMARDs) in patients with psoriatic arthritis and axial spondyloarthritis across Europe, and assess the healthcare set-ups in relation to c

In-depth exploration of the structure of pea albumin, its fractions and their heating and foaming properties

Hypothesis: The structure and functionality of pea albumin can be described in detail as a combination of its main fractions, PA1 and PA2. Experimental: PA1 and PA2 were purified from a Pea Albumin extract (PA) using size exclusion chromatography, and characterized by two-dimensional gel electrophoresis. Their secondary structure was analyzed using Fourier-Transform Infrared Spectroscopy (FTIR). T