The ubiquitin-editing enzyme A20 (TNFAIP3) and the deubiquitinase CYLD are central negative regulators of NF-kappa B signaling. Both can act by removing nonproteolytic K63-linked polyubiquitin chains from an overlapping set of signaling molecules. In B cells, A20 deficiency results in hyperactivity, loss of immune homeostasis, inflammation, and autoimmunity. The reported consequences of CYLD defic

The production of isolated photons in deep-inelastic scattering ep -> e gamma X is measured with the H1 detector at HERA. The measurement is performed in the kinematic range of negative four-momentum transfer squared 4 < Q(2)< 150 GeV2 and a mass of the hadronic system W-X > 50 GeV. The analysis is based on a total integrated luminosity of 227 pb(-1). The production cross section of isolated photo

The ability to entrap drugs within vehicles and subsequently release them has led to new treatments for a number of diseases. Based on an associative phase separation and interfacial diffusion approach, we developed a way to prepare DNA gel particles without adding any kind of cross-linker or organic solvent. Among the various agents studied, cationic surfactants offered particularly efficient con

Solljus, sand av mineralen kvarts eller fältspat samt naturligt förekommande radioaktivitet är förutsättningarna för att kunna använda så kallad luminiscensdatering. Metoden används för att åldersbestämma geologiska händelser under den senaste istiden och har bidragit till en ny syn på nedisningarna i Skandinavien.

We investigate optimal maneuvers for vehicles on different road surfaces such as asphalt, snow, and ice. This study is motivated by the desire to find control strategies for improved future vehicle safety and driver assistance technologies. Based on earlier presented empirical measurements for tire-force characteristics, we develop vehicle and tire models corresponding to different road conditions

My PhD submission is made up of a constellation of three elements that form a body of textual material / theory and practice event / exhibition. (1) A dimension of critical writing or dissertation that has two parts: (a) Retrospective / Prospective: Activating the Archive, September 1, 2010, and (b) an accretion of further analysis, Archive, Archived, Archiving, September 1, 2011. (2) A testin

Previous studies of limestone beds of mid-Ordovician age from both Sweden and China show that the Earth saw an at least two orders of magnitude increase in the influx of extraterrestrial material approximately 470 Ma, following the disruption of an L-chondrite parent body in the asteroid belt. Recovered extraterrestrial material consists of fossil meteorites and sediment-dispersed extraterrestrial

Background: Reliable data on familial risks are important for clinical counselling and cancer genetics. Objective: To evaluate familial risks for renal cell carcinomas (RCC) through parental and sibling probands in the largest available dataset. Design, setting, and participants: This study examined the Swedish Family-Cancer Database on 12.2 million individuals, which contains families with parent

Witnesses to a crime repeat and discuss the event several times during the legal process. The repetitions and discussions may influence the quality of recall as well as the confidence a witness feels in the remembered information. To probe this matter, participants in the current study viewed a short film and then either repeatedly, over a period of three weeks, 1) discussed the event in the lab 2

The reassignment technique is used to increase localization for signal components in the time-frequency representation. The technique gives perfect localization for infinite linear chirp-signals, impulses and constant frequency signals but not for short non-stationary signals. In this paper, a scaled reassignment is proposed, based on the spectrogram using a Gaussian window. The resulting reassign

Popular Abstract in Swedish Ljus växelverkar med materia på ett mycket specifikt sätt och är anledningen till att saker har färger, himlen är blå, vår spegelbild reflekteras i en spegel och att solljus kan delas upp i en regnbåge genom vattendroppar. Läran om hur ljus växelverkar med material - spektroskopi - används inom astronomi, kemi, fysik och medicin. Absorptionsspektroskopi studerar just huAbsorption spectroscopy constitutes a chemical analysis tool which can be applied to various samples and application fields. This thesis focuses on gas absorption spectroscopy with the means of diode lasers - tunable diode laser absorption spectroscopy, TDLAS. In particular, the absorption of gases inside porous scattering solids and liquids, referred to as GASMAS - gas in scattering media absorpt

Pyrazinamide (PZA) is a potent first-line agent for the treatment of tuberculosis (TB) with activity also against a significant part of drug-resistant Mycobacterium tuberculosis strains. Since PZA is active only at acid pH, testing for susceptibility to PZA is difficult and insufficiently reproducible. The recommended critical concentration for PZA susceptibility (MIC, 100 mg/liter) used in the Ba

The past few decades have witnessed the development of numerous catchment models, often with increasing structural complexity and mathematical sophistication. While such models have certainly provided a better understanding of catchments and associated processes, they are also often catchment-specific, region-specific, or process-specific. Serious concerns on this modeling trend have been increasi

This article presents an inquiry into conversations that academic teachers have about teaching. The authors investigated to whom they talk and the forms that these conversations take. The findings indicate that most teachers rely on a small number of significant others for conversations that are characterised by their privacy, by mutual trust and by their intellectual intrigue. Individual teachers

HIV-2 has a lower pathogenicity and transmission rate than HIV-1. Neutralizing antibodies could be contributing to these observations. Here we explored side by side potency and breadth of intratype and intertype neutralizing activity (NAc) in plasma of 20 HIV-1, 20 HIV-2 and 11 dually HIV-1/2 (HIV-D) seropositive individuals from Guinea-Bissau, West Africa. Panels of primary isolates, five HIV-1 a

Background: To evaluate the effect of one lesson of continuing medical education (CME) of subjective assessment of optic nerve head appearance on sensitivity and specificity for the diagnosis of glaucoma. Methods: Ophthalmologists and residents in ophthalmology attending an international glaucoma meeting arranged at Malmo University Hospital, Malmo, Sweden, were asked to grade optic nerve head (ON

The three Mn I lines at 17325, 17339, and 17349 angstrom are among the 25 strongest lines (log(gf) > 0.5) in the H band. They are all heavily broadened due to hyperfine structure, and the profiles of these lines have so far not been understood. Earlier studies of these lines even suggested that they were blended. In this work, the profiles of these three infrared (IR) lines have been studied theor

Background: The secreted enzyme EndoS, an endoglycosidase from Streptococcus pyogenes, hydrolyzes the N-linked glycan of the constant region of immunoglobulin G (IgG) heavy chain and renders the antibody unable to interact with Fc receptors and elicit effector functions. In this study we couple targeted allelic replacement mutagenesis and heterologous expression to elucidate the contribution of En