Search results

Behandling av kroniska tarmsjukdomar Är PTPN23 lösningen vi har väntat på? Alla har vi sannolikt någon gång lidit av magproblem i form av smärta eller diarré. Att drabbas av kroniska tarmsjukdomar där besvären utgör en vardag är ett globalt problem, och trots att sjukdomarna är vanliga finns idag inget botemedel. I den här studien har vi undersökt om en eliminering av molekylen PTPN23 från makrofThe gastrointestinal tract encounters foreign antigens, commensal bacteria and nutrients on a daily basis. Under steady state conditions, a regulatory immune system maintains gut homeostasis. However, disruption of the balance between regulatory components and defeating invading pathogens leads to overshooting inflammatory reactions that can culminate in chronic and relapsing intestinal inflammati

Hur kan ägg hjälpa mot barncancer? Neuroblastom är en barncancerform. Bristen på sjukdomsmodeller har saktat ner framstegen och möjligheterna att förstå hur sjukdomen uppstår. Här kan vi presentera en människo-kycklingchimär som modell för att studera neuroblastom genom att använda embryon från hönsägg tillsammans med mänskliga celler. Neuroblastom (NB) är en cancerform som oftast drabbar småbaNeuroblastoma (NB) is a childhood cancer contributing to several cases of cancer related deaths in children every year. The oncogene MYCN is known to be related to a worse outcome in patients with NB and is found in approximately 20 % of the cases. MYCN is controlled during normal development, however in NB it is dysregulated. The understanding of NB has been hampered due to the lack of embryonic

Problem description Multiple cases show that companies can improve performance after implementing an AutoStore system. However, research on optimizing the design and how to successfully control the AutoStore system is limited. Furthermore, studies focusing on optimizing operations around Robot-based Compact Storage and Retrieval Systems (RCSRS) in general, are important for the development of ope

Since the 1950's, mass tourism has become a considerable part of modern western culture. Examining where, why and how people have traveled can tell us a lot about people's habits and cultural frames of reference. Yet, the area of tourism history is fairly uncharted, with travelogs being one of the more prevalent objects of interest for academic research. Research focused on travel guides a

This study explores dance as a bodily and spatial resistance. The aim of the study is to investigate stories about and experiences of working with dance to explore the potential of dance as a resistance strategy. The study is based on qualitative semi-structured interviews with dancers, choreographers and project developers, coupled with a thematic analysis. Based on the interviewees’ stories, the

Abstract Title: Purchasing and digitalization in an era of turbulence Authors: Emil Sarajlic & Vishal Natesan Supervisor: Wilbert Baerwaldt, Director Sourcing and Value Chain at Duni AB Louise Bildsten, Department of Industrial Management & Logistics, Faculty of Engineering, Lund University Examiner: Jan Olhager, Department of Industrial Management & Logistics, Faculty of Engineeri

This master thesis was done in collaboration between the division of Production and Materials Engineering at Lund University, Faculty of Engineering, and Nolato MediTor AB. The company, located in Torekov, offers a variety of solutions for the medical device and pharmaceutical industries. The project was performed in the extrusion department that manufactures a wide variety of medical tubes and ho

Denna studie undersöker den politiska kampanjmetoden dörrknackning (canvassing) med syftet att få en inblick i hur dörrknackarna upplever den retoriska situationen ute i fält. Det empiriska materialet har samlats in genom tio kvalitativa forskningsintervjuer och analyserats med Lloyd F. Bitzers modell “The Rhetorical Situation” (1968). Slusatserna är att dörrknackning som metod är situationell i sThis study examines the rhetorical situation of door-to-door canvassing through qualitative research interviews with partisan canvassers from the Social Democratic Party in Malmö, Sweden, with the theoretical framework of Lloyd F. Bitzer's "The Rhetorical Situation" (1968). The study concludes that door-to-door canvassing is situational in its form, and must therefore respond to audi

Alzheimer's disease is a neurodegenerative disease that often affects the elderly and is accompanied by cognitive loss. The disease is characterized by the formation of amyloid beta (Aβ) plaques and Tau tangles in the brain, and microglia, the brain's resident immune cells, have been found to play a critical role in the progression of the disease. Recent studies suggest that microglia may

Russia's invasion of Ukraine has caused division among nations, with large parts of the Global South either refraining from condemning Russia or outright criticizing the West for its pro-Ukraine stance. It highlights the need to examine Russia’s public diplomacy efforts and ability to attract parts of the Global South in the context of the war. Based on this notion, the following thesis examin

Denna uppsats syftar till att få en djupare förståelse för vilka utmaningar COVID-19 pandemin och övergången till distansarbete har skapat för chefer i Sverige, samt att förstå hur chefer kan överkomma utmaningarna som uppstår. Uppsatsen kan därför bidra med ökad förståelse kring svenska chefers ledarskap vid distans- och hybridarbete. Metodvalet i uppsatsen har bestått av insamling av kvalitativ

En partikelfysikers arbete är att beskriva hur naturens minsta beståndsdelar, subatomiska partiklar, interagerar. Detta är väldigt svårt då interaktioner är fundamentalt slumpmässiga. Inte ens den bästa fysikern kan därför säga exakt vad som händer när två partiklar kolliderar, men hon eller han kan istället räkna ut sannolikheten för alla olika händelser. Detta bygger på att fysikern har tillgångThe chirality-flow formalism provides a simple but efficient way to rewrite and evaluate Feynman diagrams and has recently been shown to also optimize automated numerical scattering matrix element evaluations in massless tree-level QED. In this thesis we extend the numerical QED model to massless tree-level QCD in the MadGraph5_aMC@NLO framework. It is shown that a good gauge choice for external g

The increased prevalence of obesity is causing challenges on individual and socioeconomic levels. Neuronal subtypes of the hypothalamus control appetite regulation through the secretion of peptide hormones and neurotransmitters. Our limited knowledge of early molecular patterning of the human hypothalamus sets a challenge to design human in vitro models for cellular studies and drug screening. In

In this thesis we introduce the notion of elliptic functions, and in particular Weierstrass' Elliptic Function, in order to define the modular function $\lambda$ on the upper half plane. We establish a group ismorphism between the unimodular transformations and $\Aut{\C\setminus\{0,1\}}$. In particular this gives two functional equations involving $\lambda$, and with these equations we show th

In an era of rapid technological advancements, the digital economy has witnessed significant transformations, resulting in the emergence of dominant technology giants. The rising dominance of companies like Google and Amazon has raised concerns in the European Union (“EU”) regarding fair competition and consumer welfare. This thesis comprehensively examines the impact of digital markets and online

Averting catastrophic climate change requires private businesses to reach net zero emissions while staying within 1.5°C of global warming. The nonprofit organization Project Drawdown and the literature suggest that companies have to engage all capacities to achieve ambitious emissions reductions, including their social power, governance, political advocacy, finance, and employee creativity. I eval

This Bachelor’s degree project investigates how to create a modular chair system. It should let the consumer combine different parts to create a chair that fits their home, style and needs. The focus is on how a low number of parts can be used in different ways to create differentcombinations. It should also be easy to replace and recycle all parts when needed. This document shows the full design

In this bachelors project I am exploring how Phase Change Material can be applied into an office chair to give a cooling effect and reduce the need for air conditioning. The motivation for the project was to find solutions to lower the energy consumption. The design process includes research and ideation to a developed concept with a display prototype.

Scaling up climate finance is vital for avoiding the worst impacts of climate change and limiting global warming. In this light, multiple Voluntary Net-Zero Alliances for Financial Institutions (VNZAFIs) have been founded, directing capital flows from financial institutions towards climate action. Nonetheless, the contributions of VNZAFIs to the Paris Climate Goals can be put into question. This s