Novel monogalactoside galectin inhibitor scaffolds : Guiding selectivity with heteroaromatic interactions
Carbohydrates are involved in many cellular processes, and most biomolecules are glycosylated. Thesemodifications are used in biological systems as information carriers, helping regulate organization on the cell surfaceand interactions between cells and the environment. Galectins are a family of carbohydrate binding proteins thatbind to polysaccharides containing a galactose. Galectins have the abCarbohydrates are involved in many cellular processes, and most biomolecules are glycosylated. Thesemodifications are used in biological systems as information carriers, helping regulate organization on the cell surfaceand interactions between cells and the environment. Galectins are a family of carbohydrate binding proteins thatbind to polysaccharides containing a galactose. Galectins have the ab