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Novel monogalactoside galectin inhibitor scaffolds : Guiding selectivity with heteroaromatic interactions

Carbohydrates are involved in many cellular processes, and most biomolecules are glycosylated. Thesemodifications are used in biological systems as information carriers, helping regulate organization on the cell surfaceand interactions between cells and the environment. Galectins are a family of carbohydrate binding proteins thatbind to polysaccharides containing a galactose. Galectins have the abCarbohydrates are involved in many cellular processes, and most biomolecules are glycosylated. Thesemodifications are used in biological systems as information carriers, helping regulate organization on the cell surfaceand interactions between cells and the environment. Galectins are a family of carbohydrate binding proteins thatbind to polysaccharides containing a galactose. Galectins have the ab

Extracorporeal Arteriovenous Ultrasound Measurement of Cardiac Output in Small Children

WHAT WE ALREADY KNOW ABOUT THIS TOPIC: WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Technology for cardiac output (CO) and blood volume measurements has been developed based on blood dilution with a small bolus of physiologic body temperature saline, which, after transcardiopulmonary mixing, is detected with ultrasound sensors attached to an extracorporeal arteriovenous loop using existing

Measurements of inclusive and differential fiducial cross-sections of tt¯ production with additional heavy-flavour jets in proton-proton collisions at √s = 13 TeV with the ATLAS detector

This paper presents measurements of tt¯ production in association with additional b-jets in pp collisions at the LHC at a centre-of-mass energy of 13 TeV. The data were recorded with the ATLAS detector and correspond to an integrated luminosity of 36.1 fb −1 . Fiducial cross-section measurements are performed in the dilepton and lepton-plus-jets tt¯ decay channels. Results are presented at particl

Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci assoc

Charged-particle pseudorapidity density at mid-rapidity in p–Pb collisions at √sNN = 8.16 TeV

The pseudorapidity density of charged particles, d N ch / d η, in p–Pb collisions has been measured at a centre-of-mass energy per nucleon–nucleon pair of sNN = 8.16 TeV at mid-pseudorapidity for non-single-diffractive events. The results cover 3.6 units of pseudorapidity, | η| < 1.8. The d N ch / d η value is 19.1 ± 0.7 at | η| < 0.5. This quantity divided by ⟨ N part ⟩ / 2 is 4.73 ± 0.20 , where

Remote Supervision of an Unmanned Surface Vessel - a Comparison of Interfaces

We compared three different Graphical User Interfaces (GUI) that we have designed and implemented to enable human supervision of an unmanned ship. Our findings indicate that a 3D GUI presented either on a screen or in a Virtual Reality (VR) setting provides several objective and subjective benefits compared to a Baseline GUI representing traditional tools.

Climate control on alluvial sediment storage in the northern foreland of the Tatra Mountains since the late Pleistocene

Numerical dating and geomorphic studies on alluvial sediment were undertaken in the uppermost reaches of the Dunajec River catchment in the northern foreland of the Tatra Mountains of Poland. Successions of alluvial deposits in river terraces and alluvial fans are common in this region. In particular, alluvial fans deposited a thick succession of sediment in the intramontane Orawa-Nowy Targ Depres

Lake-level variability in Salar de Coipasa, Bolivia during the past ∼40,000 yr

Various paleoclimatic records have been used to reconstruct the hydrologic history of the Altiplano, relating this history to past variability of the South American summer monsoon. Prior studies of the southern Altiplano, the location of the world's largest salt flat, the Salar de Uyuni, and its neighbor, the Salar de Coipasa, generally agree in their reconstructions of the climate history of the

Comprehensive echocardiographic imaging of atrioventricular valves in children with atrioventricular septal defect : Accuracy of 2D and 3D imaging and reasons for disagreement

OBJECTIVE: To compare the accuracy and reasons for disagreement of two-dimensional (2D) and three-dimensional (3D) echocardiography findings in the assessment of the atrioventricular valve complex in patients with atrioventricular septal defect. METHODS: A total of 20 children (mean age 8 months) with atrioventricular septal defect were enrolled prospectively into this study. The accuracy of and t

Non-binary phase gratings for x-ray imaging with a compact Talbot interferometer

X-ray imaging using a Talbot-Lau interferometer, consisting of three binary gratings, is a well-established approach to acquire x-ray phase-contrast and dark-field images with a polychromatic source. However, challenges in the production of high aspect ratio gratings limit the construction of a compact setup for high x-ray energies. In this study we consider the use of phase gratings with triangul

Out-of-hospital cardiac arrest at place of residence is associated with worse outcomes in patients admitted to intensive care : a post-hoc analysis of the Targeted Temperature Management trial

BACKGROUND: The majority of out-of-hospital cardiac arrests (OHCAs) occur at place residence, which is associated with worse outcomes in unselected prehospital populations. Our aim was to investigate whether location of arrest was associated with outcome in a selected group of initial survivors admitted to intensive care.METHODS: This is a post-hoc analysis of the Targeted Temperature Management a

Geochemical composition of Baltic benthic foraminifera collected and cultured over a large salinity gradient.

Some of the most significant challenges in paleoclimate research arise from the need to both understand and reduce the uncertainty associated with proxies for climate reconstructions. These challenges were further highlighted in connection with the IODP Exp.347 Baltic Sea Paleoenvironment. We have investigated temperature and salinity proxies through a combination of field-and culture-based benthi

Inorganic Ions Assisted Anisotropic Growth of CsPbCl3 Nanowires with Surface Passivation Effect

All-inorganic halide perovskite nanowires (NWs) exhibit improved thermal and hydrolysis stability and could thus play a vital role in nanoscale optoelectronics. Among them, blue-light-based devices are extremely limited because of the lack of a facile method to obtain high-purity CsPbCl3 NWs. Herein, we report a direct and facile method for the synthesis of CsPbCl3 NWs assisted by inorganic ions t

Surface Engineering of Quantum Dots for Remarkably High Detectivity Photodetectors.

Ternary alloyed CdSexTe1–x colloidal QDs trap-passivated by iodide-based ligands (TBAI) are developed as building blocks for UV–NIR photodetectors. Both the few surface traps and high loading of QDs are obtained by in situ ligand exchange with TBAI. The device is sensitive to a broad wavelength range covering the UV–NIR region (300–850 nm), showing an excellent photoresponsivity of 53 mA/W, a fast

Skjutvapens- och explosionsvåld

Det skjutvapenrelaterade våldet i Sverige har ökat kraftigt sedan 1990-talet, och trots att hela Sverige är drabbat sticker Region Skåne och då främst Malmö ut. Även om en stor del av skottlossningarna riktas mot byggnader och fordon dör och skadas årligen ett tiotal personer i staden. Även explosionsvåldet har ökat både i landet och i Malmö och det kan vara ett tecken på ett trendbrott inom den gGun-related violence in Sweden has increased dramatically since the 1990s, and while the entire country has been affected, the Skåne region and Malmö in particular stand out. Although many of the shootings are directed at buildings and vehicles, more than ten people are killed and injured in the city every year. Violence caused by explosives has also increased both in Malmö and in the country as a

Gärningsmannen, brottet och offret

Förutom att Malmö har flest anmälda brott i relation till sin folkmängd, är det också en av de städer i landet med högst andel skjutvapenrelaterat våld. Våra tidigare studier visar att de som begår grova brott som mord eller dråp och försök till mord eller dråp i Malmö främst är ensamstående, har ingen psykiatrisk diagnos och använder sig främst av kniv eller annat vasst tillhygge vid sina dåd, ävIn addition to Malmö having the most reported crimes in relation to its population, it is also one of the cities in the country with the highest percentage of gun-related violence. Our earlier studies show that people who commit serious crimes such as homicide or attempted homicide in Malmö are primarily single, have no psychiatric diagnosis and mainly use knives or other sharp weapons to commit t