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Trots att majoriteten av dem som dör av opioidöverdoser haft kontakt med sjukvård, socialtjänst eller kriminalvård, visar en ny analys att en stor grupp – nästan hälften – saknar betydande vårdkontakter kopplade till sina drogproblem. För att stärka det förebyggande arbetet mot överdoser behövs en förändring i vården, där lågtröskelinsatser kompletteras med bredare screening och mindre stigmatiserDespite the fact that the majority of those who die from opioid overdoses have been in contact with healthcare, social services, or the justice system, a new analysis shows that a large group – nearly half – lacks significant care connections related to their drug problems. To strengthen preventive efforts against overdoses, a change in care is needed, where low-threshold interventions are complem

European semi-natural grasslands are hotspots for biodiversity and important for the provisioning of multiple ecosystem services, but their extent has declined considerably during the past century. Increasing demands for agricultural and forest biomass risk causing further loss of grasslands, raising concern about a goal conflict between climate mitigation and biodiversity conservation. This study

The Gaia-ESO Survey is an European Southern Observatory (ESO) public spectroscopic survey that targeted 105 stars in the Milky Way covering the major populations of the disk, bulge and halo. The observations were made using FLAMES on the VLT obtaining both UVES high (R ~ 47 000) and GIRAFFE medium (R ~ 20 000) resolution spectra. The analysis of the Gaia-ESO spectra was the work of multiple analys

Outcome under-ascertainment, characterized by the incomplete identification or reporting of cases, poses a substantial challenge in epidemiologic research. While capture-recapture methods can estimate unknown case numbers, their role in estimating exposure effects in observational studies is not well established. This paper presents an ascertainment probability weighting framework that integrates

Context. The TOI-178 system consists of a nearby, late-K-dwarf with six transiting planets in the super-Earth to mini-Neptune regime, with radii ranging from ∼1.1 to 2.9 R⊕ and orbital periods between 1.9 and 20.7 days. All the planets, but the innermost one, form a chain of Laplace resonances. The fine-tuning and fragility of such orbital configurations ensure that no significant scattering or co

Background: The Occupational Balance Questionnaire (OBQ11) is a commonly used instrument for measuring self-rated occupational balance. It needs further development, and therefore an additional 11 tentative items have been developed. One aspect of this is studying the interpretations and reasoning of people responding to the items/instrument. Aim: The aim of this study was to explore and describe

The market for home deliveries of food and groceries has been growing in the last years, and with it so have the associated environmental impacts: emissions from the delivery routes, energy for the cold chain and packaging waste are some of the main concerns. The purpose of this paper is to contribute with knowledge to support the development and implementation of circular retail supply chains, wi

Travel and tourism have become an increasingly important sociocultural and economic phenomena in the contemporary globalized world. As an arena in which people and businesses from different countries come into contact, tourism operates within the framework of particular spatial patterns and is closely bound up with issues of foreign policy, international relations, public policy and the exercise o

Background: The rising incidence of melanoma and the high number of benign lesions excised due to diagnostic uncertainty highlight the need for effective patient triage. This study assesses the safety and accuracy of teledermoscopic triage on a high-prevalence case set with pre-triaged, challenging, melanoma-suspicious lesions. Methods: Five dermatologists independently reviewed 250 retrospectivel

Background: Screen time among children and adolescents has increased dramatically, raising concerns about its impact on development and mental health. While research highlights both potential benefits and risks, excessive use has been linked to issues like anxiety, depression, and gaming addiction. Despite growing concern, effective interventions are scarce. Recognizing the importance of family dy

Crystallization-induced stress within confined spaces of porous materials presents significant challenges across various disciplines, including conservation science, geomorphology, geotechnical engineering, and concrete durability. Despite its significance, understanding how localized, transient, and anisotropic stress is generated in pores due to salt crystallization, along with its mechanisms of

Mutations in the PINK1 and PRKN genes are the most frequent genetic cause of early-onset Parkinson disease. The pathogenic p.R275W substitution in PRKN is the most frequent substitution observed in patients, and thus far has been characterized mostly through overexpression models that suggest a possible gain of toxic misfunction. However, its effects under endogenous conditions are largely unknown

Tourism research does not exist in a vacuum. It is affected not only by changes in tourism consumption and production, but also wider global events and the shifting priorities and policies of higher education institutions and research funders which have placed a stronger emphasis on assessments research output quality, public-private partnerships and relevance (however defined). The constant fluid

A comprehensive approach to ecological functional zoning in the Shenzhen region of China is presented in this study. Through the integration of advanced geospatial analysis tools, multiple data sources, and sophisticated statistical techniques, different ecological functions have been identified and categorized based on a comprehensive set of indicators and spatial analysis techniques. The three-l

Background Task-sharing of spinal anaesthesia care by non-specialist graduate physicians, termed medical officers (MOs), is commonly practised in rural Indian healthcare facilities to mitigate workforce constraints. We sought to assess whether spinal anaesthesia failure rates of MOs were non-inferior to those of consultant anaesthesiologists (CA) following a standardised educational curriculum. Me

Background Mothers attending prevention of mother-to-child transmission (PMTCT) of HIV clinics seem to lack knowledge on many aspects of PMTCT, among which is breastfeeding. Breastfeeding recommendations in PMTCT have changed several times over the years leaving some confused and doubtful of what is currently recommended. One method shown to help improve their knowledge and acceptance of PMTCT rec